<?xml version="1.0" encoding="ISO-8859-1"?>
<neuroml xmlns="http://www.neuroml.org/schema/neuroml2" 
         xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" 
         xsi:schemaLocation="http://www.neuroml.org/schema/neuroml2 https://raw.github.com/NeuroML/NeuroML2/development/Schemas/NeuroML2/NeuroML_v2beta4.xsd" 
         id="NaTs">
    

    <notes>NeuroML file containing a single Channel description</notes>

    <ionChannel id="NaTs" conductance="10pS" type="ionChannelHH" species="na">

        <notes>Fast inactivating Na+ current. 
Modified slightly for Allen Institute cell models from Hay et al. 2011 version:
 - Added Q10 scaling to rate variables 
 - Values for midpoint changed to match mod 
            
Comment from mod file (NaTs2_t.mod): took the NaTa and shifted both activation/inactivation by 6 mv</notes>
                
        <annotation>
            <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
                <rdf:Description rdf:about="NaTs2_t">
                    
                    <bqmodel:isDescribedBy xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
                        <rdf:Bag>
                            <rdf:li>Models of Neocortical Layer 5b Pyramidal Cells Capturing a Wide Range of Dendritic and Perisomatic Active Properties,
            Etay Hay, Sean Hill, Felix Schürmann, Henry Markram and Idan Segev, PLoS Comp Biol 2011</rdf:li>
                            <rdf:li rdf:resource="http://www.ncbi.nlm.nih.gov/pubmed/21829333"/>
                        </rdf:Bag>
                    </bqmodel:isDescribedBy>

                
                    <bqbiol:isVersionOf xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
                        <rdf:Bag>
                            <rdf:li>Na channels</rdf:li>
                            <rdf:li rdf:resource="http://senselab.med.yale.edu/neurondb/channelGene2.aspx#table2"/>
                        </rdf:Bag>
                    </bqbiol:isVersionOf>

                </rdf:Description>
            </rdf:RDF>
        </annotation>

        <gate id="m" type="gateHHrates" instances="3">
            <q10Settings type="q10ExpTemp" q10Factor="2.3" experimentalTemp="23 degC"/>
            <forwardRate type="HHExpLinearRate" rate="1.092per_ms" scale="6mV" midpoint="-40mV"/>
            <reverseRate type="HHExpLinearRate" rate="0.744per_ms" scale="-6mV" midpoint="-40mV"/>
        </gate>

        <gate id="h" type="gateHHrates" instances="1">
            <q10Settings type="q10ExpTemp" q10Factor="2.3" experimentalTemp="23 degC"/>
            <forwardRate type="HHExpLinearRate" rate="0.09per_ms" scale="-6mV" midpoint="-66mV"/>
            <reverseRate type="HHExpLinearRate" rate="0.09per_ms" scale="6mV" midpoint="-66mV"/>
        </gate>
                            
    </ionChannel>

</neuroml>
