Hippocampus CA1 Schaffer Collateral-Associated (SCA) Cell

Model Type:
Cell
Neurolex IDs: None
Keywords: None
Publication: Bezaire, et. al. (2016) Interneuronal mechanisms of hippocampal theta oscillations in a full-scale model of the rodent CA1 circuit.
Authors:
Marianne J Bezaire   Ivan Raikov   Kelly Burk   Dhrumil Vyas   Ivan Soltesz  
Translators: Andras Ecker   Padraig Gleeson   Marianne Bezaire  
Sources:
Files:
Model ID NeuroML File
NMLCL001630
sca.cell.nml
( view NeuroML )
NMLCH001605
HCN.channel.nml
( view NeuroML )
NMLCH001607
CavL.channel.nml
( view NeuroML )
NMLCH001616
KCaS.channel.nml
( view NeuroML )
NMLCH001618
KvA.channel.nml
( view NeuroML )
NMLCH001622
KvGroup.channel.nml
( view NeuroML )
NMLCH001623
leak_chan.channel.nml
( view NeuroML )
NMLCH001626
Navcck.channel.nml
( view NeuroML )
NMLCH001627
Kdrfast.channel.nml
( view NeuroML )
NMLCH001632
CavN.channel.nml
( view NeuroML )
NMLCH001639
KvCaB.channel.nml
( view NeuroML )
NMLCN001629
Capool.nml
( view NeuroML )
Notes: None
Model Id: NMLCL001630
Associated Channels:
Associated Synapses: None
Associated Networks:
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Non-accommodating Regular Spikers (naRS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -70.10 mV
Rheobase Current Interval (0.03273, 0.03525] nA
Threshold Current Interval (0.58594, 0.64453] nA
Bias Current (to -80.00 mV) -0.0459 nA
Testing Temperature 34.0 °C
Stability Interval [-1.5625, 15.0] nA
AP 1-2 Amplitude Drop 0.8815 mV
AP 1 Steady State Amplitude Change 0.7737 mV
AP 1 Amplitude 83.9171 mV
AP 1 Width at Half Height 1.6400 ms
AP 1 Width (Peak To Trough) 14.0700 ms
AP 1 Rate of Change Peak to Trough -7.7972 mV/ms
AP 1 AHP Depth 25.7896 mV
AP2 Amplitude 83.0356 mV
AP2 Width at Half Height 1.6300 ms
AP 2 Width (Peak to Trough) 13.6200 ms
AP 2 Rate of Change Peak to Trough -8.0568 mV/ms
AP 2 AHP Depth 26.6973 mV
AP 1-2 Amplitude Change Percent -1.0505 %
AP 1-2 Half Width Change Percent -0.6098 %
AP 1-2 Rate of Change Peak to Trough Percent Change 3.3286 %
AP 1-2 AHP Depth Percent Change 3.5197 %
Input Resistance 187.9526 MΩ
AP 1 Delay Mean 65.2000 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 161.5300 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 97.1250 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean 0.0000 %
Steady State Accommodation Mean 0.0000 %
Accommodation Rate to Steady State 0.0000 %/ms
Accommodation at Steady State Mean -2.5597 %
Accommodation Rate Mean at Steady State 83.9749 ms
ISI CV 166.1777
ISI Median 98.7600 ms
ISI Burst Mean Change 1.6506 %
Spike Rate (Strong Stimulation) 22.0000 Hz
AP 1 Delay Mean (Strong Stimulation) 24.5000 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 69.8400 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 45.6700 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2119.0000 ms
Frequency Filter Type Low-Pass
Frequency Filter Pass Below 118.2613 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 2356.19 µm2
Number of Stems 3.0
Number of Bifurcations 3.0
Number of Branches 7.0
Overall Width 447.831 µm
Overall Height 838.955 µm
Overall Depth 0.0 µm
Average Diameter 2.45 µm
Total Length 1817.5 µm
Total Surface 9687.89 µm2
Total Volume 5393.03 µm3
Max Euclidean Distance 609.223 µm
Max Path Distance 610.0 µm
Max Branch Order 1.0
Average Contraction 0.999907
Total Fragmentation 38.0
Partition Asymmetry 0.0
Average Rall's Ratio 1.5575
Average Bifurcation Angle Local 45.8366 °
Average Bifurcation Angle Remote 45.7441 °
Fractal Dimension 1.0
Complexity Summary
State Equations 742
Optimal Time-Step 0.00537 ms
Relative Complexity 210.30 HH
Model Size
Sections 17
Compartments 53
State Equations 742
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00537 ms
Optimal Time-Step Error 0.02 %
Optimal Time-Step Benchmark Run Time 210.30 HH
 
Maximum Stable Time-Step 0.03125 ms
Maximum Stable Time-Step Error 9.53 %
Max. Stable Time-Step Benchmark Run Time 563.96 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 101386 Hz
CVODE Steps Per AP 4452
CVODE Benchmark Run Time 1082.19 HH
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