Hippocampus CA1 CCK+ Basket Cell

Model Type:
Cell
Neurolex IDs: None
Keywords: None
Publication: Bezaire, et. al. (2016) Interneuronal mechanisms of hippocampal theta oscillations in a full-scale model of the rodent CA1 circuit.
Authors:
Marianne J Bezaire   Ivan Raikov   Kelly Burk   Dhrumil Vyas   Ivan Soltesz  
Translators: Andras Ecker   Padraig Gleeson   Marianne Bezaire  
Sources:
Files:
Model ID NeuroML File
NMLCL001617
cck.cell.nml
( view NeuroML )
NMLCH001605
HCN.channel.nml
( view NeuroML )
NMLCH001607
CavL.channel.nml
( view NeuroML )
NMLCH001616
KCaS.channel.nml
( view NeuroML )
NMLCH001618
KvA.channel.nml
( view NeuroML )
NMLCH001622
KvGroup.channel.nml
( view NeuroML )
NMLCH001623
leak_chan.channel.nml
( view NeuroML )
NMLCH001626
Navcck.channel.nml
( view NeuroML )
NMLCH001627
Kdrfast.channel.nml
( view NeuroML )
NMLCH001632
CavN.channel.nml
( view NeuroML )
NMLCH001639
KvCaB.channel.nml
( view NeuroML )
NMLCN001629
Capool.nml
( view NeuroML )
Notes: None
Model Id: NMLCL001617
Associated Channels:
Associated Synapses: None
Associated Networks:
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Non-accommodating Regular Spikers (naRS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -70.17 mV
Rheobase Current Interval (0.05768, 0.06088] nA
Threshold Current Interval (0.76172, 0.82031] nA
Bias Current (to -80.00 mV) -0.0628 nA
Testing Temperature 34.0 °C
Stability Interval [-1.5625, 15.0] nA
AP 1-2 Amplitude Drop 0.2115 mV
AP 1 Steady State Amplitude Change 0.6469 mV
AP 1 Amplitude 57.0157 mV
AP 1 Width at Half Height 2.1900 ms
AP 1 Width (Peak To Trough) 23.6500 ms
AP 1 Rate of Change Peak to Trough -3.4460 mV/ms
AP 1 AHP Depth 24.4815 mV
AP2 Amplitude 56.8041 mV
AP2 Width at Half Height 2.1900 ms
AP 2 Width (Peak to Trough) 23.5000 ms
AP 2 Rate of Change Peak to Trough -3.4664 mV/ms
AP 2 AHP Depth 24.6572 mV
AP 1-2 Amplitude Change Percent -0.3710 %
AP 1-2 Half Width Change Percent 0.0000 %
AP 1-2 Rate of Change Peak to Trough Percent Change 0.5940 %
AP 1-2 AHP Depth Percent Change 0.7177 %
Input Resistance 96.6221 MΩ
AP 1 Delay Mean 52.4700 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 150.1200 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 98.2150 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean 0.0000 %
Steady State Accommodation Mean 0.0000 %
Accommodation Rate to Steady State 0.0000 %/ms
Accommodation at Steady State Mean -0.0000 %
Accommodation Rate Mean at Steady State 31789.1981 ms
ISI CV 120.1310
ISI Median 97.5500 ms
ISI Burst Mean Change 1.1572 %
Spike Rate (Strong Stimulation) 20.5000 Hz
AP 1 Delay Mean (Strong Stimulation) 19.5900 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 69.1700 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 50.5750 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2082.1200 ms
Frequency Filter Type Low-Pass
Frequency Filter Pass Below 53.9516 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 4712.39 µm2
Number of Stems 3.0
Number of Bifurcations 3.0
Number of Branches 7.0
Overall Width 447.831 µm
Overall Height 848.955 µm
Overall Depth 0.0 µm
Average Diameter 2.45 µm
Total Length 1835.0 µm
Total Surface 10013.8 µm2
Total Volume 6053.26 µm3
Max Euclidean Distance 618.471 µm
Max Path Distance 620.0 µm
Max Branch Order 1.0
Average Contraction 0.999815
Total Fragmentation 38.0
Partition Asymmetry 0.0
Average Rall's Ratio 1.5575
Average Bifurcation Angle Local 45.8366 °
Average Bifurcation Angle Remote 45.6522 °
Fractal Dimension 1.00001
Complexity Summary
State Equations 742
Optimal Time-Step 0.00515 ms
Relative Complexity 226.00 HH
Model Size
Sections 17
Compartments 53
State Equations 742
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00515 ms
Optimal Time-Step Error 0.02 %
Optimal Time-Step Benchmark Run Time 226.00 HH
 
Maximum Stable Time-Step 0.03125 ms
Maximum Stable Time-Step Error 11.34 %
Max. Stable Time-Step Benchmark Run Time 581.24 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 84540 Hz
CVODE Steps Per AP 3545
CVODE Benchmark Run Time 917.21 HH
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