Nucleus Reticularis (nRT) Thalami Cell

Model Type:
Cell
Neurolex IDs: Thalamus reticular nucleus cell
Keywords: muticompartment,soma,dendrites,axon,kainate,persistent gamma oscillations,thalamocortical sleep spindles,synchronized population bursts,electrographic seizures,isolated double population bursts with superimposed very fast oscillations,spike-wave,polyspike-wave,fast runs,epileptiform bursts,Electrical coupling
Publication: Traub, et. al. (2005) Single-column thalamocortical network model exhibiting gamma oscillations, sleep spindles, and epileptogenic bursts
Authors:
RD Traub   D Contreras   MO Cunningham   H Murray   FE LeBeau   A Roopun   A Bibbig   WB Wilent   MJ Higley   MA Whittington  
Translators: Padraig Gleeson   Eugenio Piasini   Chaitanya Chintaluri   Daniel Wojcik   Helena Glabska   Jacek Rogala   Michael Hines   Subhasis Ray   Tom├ís Alfonso   Yates Buckley  
Sources:
Files:
Model ID NeuroML File
NMLCL001147
nRT.cell.nml
( view NeuroML )
NMLCH000141
ar__m00.channel.nml
( view NeuroML )
NMLCH000143
cal.channel.nml
( view NeuroML )
NMLCH000144
cat_a.channel.nml
( view NeuroML )
NMLCH000146
k2.channel.nml
( view NeuroML )
NMLCH000148
ka.channel.nml
( view NeuroML )
NMLCH000150
kahp_slower.channel.nml
( view NeuroML )
NMLCH000153
kc.channel.nml
( view NeuroML )
NMLCH000154
kdr_fs.channel.nml
( view NeuroML )
NMLCH000156
km.channel.nml
( view NeuroML )
NMLCH000161
naf2__a0__b0__c0__d0__fastNa_shift0.channel.nml
( view NeuroML )
NMLCH000165
napf__a0__b0__c0__d0__fastNa_shift0.channel.nml
( view NeuroML )
NMLCH000172
pas.channel.nml
( view NeuroML )
NMLCN000007
cad__beta0_05__phi260000.nml
( view NeuroML )
NMLCN000016
cad__beta0_02__phi10400.nml
( view NeuroML )
Notes: None
Model Id: NMLCL001147
Associated Channels:
Associated Synapses: None
Associated Networks:
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Accommodating Fast Spikers (aFS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -79.61 mV
Rheobase Current Interval (0.27695, 0.27946] nA
Threshold Current Interval (0.58594, 0.64453] nA
Bias Current (to -70.00 mV) 0.2153 nA
Testing Temperature 6.3 °C
Stability Interval [-2.1875, 15.0] nA
AP 1-2 Amplitude Drop 6.2192 mV
AP 1 Steady State Amplitude Change 1.3736 mV
AP 1 Amplitude 92.0082 mV
AP 1 Width at Half Height 0.3900 ms
AP 1 Width (Peak To Trough) 1.1400 ms
AP 1 Rate of Change Peak to Trough -89.2090 mV/ms
AP 1 AHP Depth 9.6901 mV
AP2 Amplitude 85.7890 mV
AP2 Width at Half Height 0.3700 ms
AP 2 Width (Peak to Trough) 1.1000 ms
AP 2 Rate of Change Peak to Trough -90.3126 mV/ms
AP 2 AHP Depth 13.5548 mV
AP 1-2 Amplitude Change Percent -6.7594 %
AP 1-2 Half Width Change Percent -5.1282 %
AP 1-2 Rate of Change Peak to Trough Percent Change 1.2370 %
AP 1-2 AHP Depth Percent Change 39.8833 %
Input Resistance 0.4076 MΩ
AP 1 Delay Mean 6.3100 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 9.8200 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 3.1600 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -58.6207 %
Steady State Accommodation Mean -41.3793 %
Accommodation Rate to Steady State -0.2053 %/ms
Accommodation at Steady State Mean -105.1238 %
Accommodation Rate Mean at Steady State 109.2477 ms
ISI CV 0.4830
ISI Median 4.5400 ms
ISI Burst Mean Change -19.9430 %
Spike Rate (Strong Stimulation) 365.0000 Hz
AP 1 Delay Mean (Strong Stimulation) 1.9400 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 4.7900 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 2.5750 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2107.8700 ms
Frequency Filter Type Band-Stop
Frequency Filter Pass Above 39.4319 Hz
Frequency Filter Pass Below 34.9627 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 0.0 µm2
Number of Stems 0.0
Number of Bifurcations 13.0
Number of Branches 27.0
Overall Width 811.047 µm
Overall Height 811.047 µm
Overall Depth 153.11 µm
Average Diameter 1.55029 µm
Total Length 4288.18 µm
Total Surface 16565.6 µm2
Total Volume 12796.9 µm3
Max Euclidean Distance 578.111 µm
Max Path Distance 696.52 µm
Max Branch Order 6.0
Average Contraction 0.998038
Total Fragmentation 122.0
Partition Asymmetry 0.450916
Average Rall's Ratio 1.432
Average Bifurcation Angle Local 67.5221 °
Average Bifurcation Angle Remote 74.8987 °
Fractal Dimension 1.0
Complexity Summary
State Equations 16706
Optimal Time-Step 0.00379 ms
Relative Complexity 7654.92 HH
Model Size
Sections 59
Compartments 1078
State Equations 16706
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00379 ms
Optimal Time-Step Error 0.50 %
Optimal Time-Step Benchmark Run Time 7654.92 HH
 
Maximum Stable Time-Step 0.015625 ms
Maximum Stable Time-Step Error 1.28 %
Max. Stable Time-Step Benchmark Run Time 29005.25 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 97694 Hz
CVODE Steps Per AP 210
CVODE Benchmark Run Time 19034.91 HH
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