Thalamocortical Relay (TCR) Cell

Model Type:
Cell
Neurolex IDs: None
Keywords: muticompartment,soma,dendrites,axon,kainate,persistent gamma oscillations,thalamocortical sleep spindles,synchronized population bursts,electrographic seizures,isolated double population bursts with superimposed very fast oscillations,spike-wave,polyspike-wave,fast runs,epileptiform bursts,Electrical coupling
Publication: Traub, et. al. (2005) Single-column thalamocortical network model exhibiting gamma oscillations, sleep spindles, and epileptogenic bursts
Authors:
RD Traub   D Contreras   MO Cunningham   H Murray   FE LeBeau   A Roopun   A Bibbig   WB Wilent   MJ Higley   MA Whittington  
Translators: Padraig Gleeson   Eugenio Piasini   Chaitanya Chintaluri   Daniel Wojcik   Helena Glabska   Jacek Rogala   Michael Hines   Subhasis Ray   Tom├ís Alfonso   Yates Buckley  
Sources:
Files:
Model ID NeuroML File
NMLCL001146
TCR.cell.nml
( view NeuroML )
NMLCH000140
ar__m00_25.channel.nml
( view NeuroML )
NMLCH000143
cal.channel.nml
( view NeuroML )
NMLCH000145
cat.channel.nml
( view NeuroML )
NMLCH000146
k2.channel.nml
( view NeuroML )
NMLCH000148
ka.channel.nml
( view NeuroML )
NMLCH000150
kahp_slower.channel.nml
( view NeuroML )
NMLCH000153
kc.channel.nml
( view NeuroML )
NMLCH000155
kdr.channel.nml
( view NeuroML )
NMLCH000156
km.channel.nml
( view NeuroML )
NMLCH000158
naf_tcr__sh_hmin7__sh_m_imin3__sh_m_rmin2_5.channel.nml
( view NeuroML )
NMLCH000169
napf_tcr__a0__b0__c0__d0__fastNa_shift7.channel.nml
( view NeuroML )
NMLCH000172
pas.channel.nml
( view NeuroML )
NMLCN000013
cad__beta0_02__phi52000.nml
( view NeuroML )
NMLCN000014
cad__beta0_05__phi104000.nml
( view NeuroML )
Notes: None
Model Id: NMLCL001146
Associated Channels:
Associated Synapses: None
Associated Networks:
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Fast Spikers (FS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -69.97 mV
Rheobase Current Interval (1.24374, 1.24969] nA
Threshold Current Interval (1.46484, 1.52344] nA
Bias Current (to -80.00 mV) -0.8359 nA
Testing Temperature 6.3 °C
Stability Interval [-10.0, 15.0] nA
AP 1-2 Amplitude Drop 5.0479 mV
AP 1 Steady State Amplitude Change -3.9639 mV
AP 1 Amplitude 69.2492 mV
AP 1 Width at Half Height 0.4200 ms
AP 1 Width (Peak To Trough) 1.2700 ms
AP 1 Rate of Change Peak to Trough -61.3850 mV/ms
AP 1 AHP Depth 8.7098 mV
AP2 Amplitude 64.2013 mV
AP2 Width at Half Height 0.4700 ms
AP 2 Width (Peak to Trough) 1.1500 ms
AP 2 Rate of Change Peak to Trough -62.5402 mV/ms
AP 2 AHP Depth 7.7199 mV
AP 1-2 Amplitude Change Percent -7.2895 %
AP 1-2 Half Width Change Percent 11.9048 %
AP 1-2 Rate of Change Peak to Trough Percent Change 1.8818 %
AP 1-2 AHP Depth Percent Change -11.3649 %
Input Resistance 0.2936 MΩ
AP 1 Delay Mean 2.2500 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 6.2300 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 4.0000 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -25.0000 %
Steady State Accommodation Mean -28.8462 %
Accommodation Rate to Steady State -0.0331 %/ms
Accommodation at Steady State Mean -45.4286 %
Accommodation Rate Mean at Steady State 365.8793 ms
ISI CV 7.0476
ISI Median 10.3100 ms
ISI Burst Mean Change 1.0050 %
Spike Rate (Strong Stimulation) 380.5000 Hz
AP 1 Delay Mean (Strong Stimulation) 2.8500 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 5.2000 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 2.3050 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2182.8800 ms
Frequency Filter Type Band-Stop
Frequency Filter Pass Above 117.6121 Hz
Frequency Filter Pass Below 30.4872 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 0.0 µm2
Number of Stems 0.0
Number of Bifurcations 91.0
Number of Branches 183.0
Overall Width 254.199 µm
Overall Height 248.26 µm
Overall Depth 125.11 µm
Average Diameter 1.17963 µm
Total Length 6770.15 µm
Total Surface 23281.5 µm2
Total Volume 18383.3 µm3
Max Euclidean Distance 196.013 µm
Max Path Distance 242.0 µm
Max Branch Order 14.0
Average Contraction 0.969481
Total Fragmentation 324.0
Partition Asymmetry 0.446131
Average Rall's Ratio 2.51607
Average Bifurcation Angle Local 73.3367 °
Average Bifurcation Angle Remote 50.5933 °
Fractal Dimension 1.0
Complexity Summary
State Equations 22084
Optimal Time-Step 0.00558 ms
Relative Complexity 5134.83 HH
Model Size
Sections 137
Compartments 1472
State Equations 22084
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00558 ms
Optimal Time-Step Error 1.40 %
Optimal Time-Step Benchmark Run Time 5134.83 HH
 
Maximum Stable Time-Step 0.03125 ms
Maximum Stable Time-Step Error 2.53 %
Max. Stable Time-Step Benchmark Run Time 14326.39 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 47782 Hz
CVODE Steps Per AP 153
CVODE Benchmark Run Time 9291.02 HH
Website & Images Copyright NeuroML © 2022 For questions: Contact us Links: Search Test |  ModelDB WS