Superficial Low Threshold Spiking (LTS) Interneuron Cell

Model Type:
Cell
Neurolex IDs: None
Keywords: muticompartment,soma,dendrites,axon,kainate,persistent gamma oscillations,thalamocortical sleep spindles,synchronized population bursts,electrographic seizures,isolated double population bursts with superimposed very fast oscillations,spike-wave,polyspike-wave,fast runs,epileptiform bursts,Electrical coupling
Publication: Traub, et. al. (2005) Single-column thalamocortical network model exhibiting gamma oscillations, sleep spindles, and epileptogenic bursts
Authors:
RD Traub   D Contreras   MO Cunningham   H Murray   FE LeBeau   A Roopun   A Bibbig   WB Wilent   MJ Higley   MA Whittington  
Translators: Padraig Gleeson   Eugenio Piasini   Chaitanya Chintaluri   Daniel Wojcik   Helena Glabska   Jacek Rogala   Michael Hines   Subhasis Ray   Tom├ís Alfonso   Yates Buckley  
Sources:
Files:
Model ID NeuroML File
NMLCL001145
SupLTSInter.cell.nml
( view NeuroML )
NMLCH000140
ar__m00_25.channel.nml
( view NeuroML )
NMLCH000143
cal.channel.nml
( view NeuroML )
NMLCH000144
cat_a.channel.nml
( view NeuroML )
NMLCH000146
k2.channel.nml
( view NeuroML )
NMLCH000148
ka.channel.nml
( view NeuroML )
NMLCH000150
kahp_slower.channel.nml
( view NeuroML )
NMLCH000152
kc_fast.channel.nml
( view NeuroML )
NMLCH000154
kdr_fs.channel.nml
( view NeuroML )
NMLCH000156
km.channel.nml
( view NeuroML )
NMLCH000162
naf2__a0__b0__c0__d0__fastNa_shiftmin2_5.channel.nml
( view NeuroML )
NMLCH000164
nap.channel.nml
( view NeuroML )
NMLCH000172
pas.channel.nml
( view NeuroML )
NMLCN000003
cad__beta0_02__phi260000.nml
( view NeuroML )
NMLCN000004
cad__beta0_05__phi520000.nml
( view NeuroML )
Notes: None
Model Id: NMLCL001145
Associated Channels:
Associated Synapses: None
Associated Networks:
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Accommodating Fast Spikers (aFS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -78.76 mV
Rheobase Current Interval (0.27809, 0.28015] nA
Threshold Current Interval (0.46875, 0.52734] nA
Bias Current (to -70.00 mV) 0.1880 nA
Testing Temperature 6.3 °C
Stability Interval [-1.875, 15.0] nA
AP 1-2 Amplitude Drop 11.3106 mV
AP 1 Steady State Amplitude Change 2.5334 mV
AP 1 Amplitude 89.5154 mV
AP 1 Width at Half Height 0.3800 ms
AP 1 Width (Peak To Trough) 0.7400 ms
AP 1 Rate of Change Peak to Trough -135.8036 mV/ms
AP 1 AHP Depth 10.9792 mV
AP2 Amplitude 78.2049 mV
AP2 Width at Half Height 0.4400 ms
AP 2 Width (Peak to Trough) 0.7400 ms
AP 2 Rate of Change Peak to Trough -120.2093 mV/ms
AP 2 AHP Depth 10.7500 mV
AP 1-2 Amplitude Change Percent -12.6353 %
AP 1-2 Half Width Change Percent 15.7895 %
AP 1-2 Rate of Change Peak to Trough Percent Change -11.4830 %
AP 1-2 AHP Depth Percent Change -2.0873 %
Input Resistance 0.6117 MΩ
AP 1 Delay Mean 4.4900 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 8.5100 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 3.7800 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -50.0000 %
Steady State Accommodation Mean -50.0000 %
Accommodation Rate to Steady State -0.3527 %/ms
Accommodation at Steady State Mean -114.4763 %
Accommodation Rate Mean at Steady State 59.6398 ms
ISI CV 1.9904
ISI Median 52.9000 ms
ISI Burst Mean Change -11.9403 %
Spike Rate (Strong Stimulation) 277.5000 Hz
AP 1 Delay Mean (Strong Stimulation) 1.7700 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 4.7500 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 2.1600 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2296.0100 ms
Frequency Filter Type High-Pass
Frequency Filter Pass Above 129.7699 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 0.0 µm2
Number of Stems 0.0
Number of Bifurcations 13.0
Number of Branches 27.0
Overall Width 355.992 µm
Overall Height 448.023 µm
Overall Depth 355.99 µm
Average Diameter 1.45703 µm
Total Length 2425.15 µm
Total Surface 9240.12 µm2
Total Volume 6058.03 µm3
Max Euclidean Distance 332.963 µm
Max Path Distance 364.481 µm
Max Branch Order 6.0
Average Contraction 0.997837
Total Fragmentation 123.0
Partition Asymmetry 0.450916
Average Rall's Ratio 1.74889
Average Bifurcation Angle Local 85.2864 °
Average Bifurcation Angle Remote 83.4952 °
Fractal Dimension 1.0
Complexity Summary
State Equations 15898
Optimal Time-Step 0.00378 ms
Relative Complexity 7890.22 HH
Model Size
Sections 59
Compartments 1130
State Equations 15898
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00378 ms
Optimal Time-Step Error 0.21 %
Optimal Time-Step Benchmark Run Time 7890.22 HH
 
Maximum Stable Time-Step 0.015625 ms
Maximum Stable Time-Step Error 0.64 %
Max. Stable Time-Step Benchmark Run Time 29843.47 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 96608 Hz
CVODE Steps Per AP 307
CVODE Benchmark Run Time 19560.59 HH
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