Layer 6 Nontufted Regular Spiking (RS) Pyramidal Cell

Model Type:
Cell
Neurolex IDs: Pyramidal Cell
Keywords: muticompartment,soma,dendrites,axon,kainate,persistent gamma oscillations,thalamocortical sleep spindles,synchronized population bursts,electrographic seizures,isolated double population bursts with superimposed very fast oscillations,spike-wave,polyspike-wave,fast runs,epileptiform bursts,Electrical coupling
Publication: Traub, et. al. (2005) Single-column thalamocortical network model exhibiting gamma oscillations, sleep spindles, and epileptogenic bursts
Authors:
RD Traub   D Contreras   MO Cunningham   H Murray   FE LeBeau   A Roopun   A Bibbig   WB Wilent   MJ Higley   MA Whittington  
Translators: Padraig Gleeson   Eugenio Piasini   Chaitanya Chintaluri   Daniel Wojcik   Helena Glabska   Jacek Rogala   Michael Hines   Subhasis Ray   Tom├ís Alfonso   Yates Buckley  
Sources:
Files:
Model ID NeuroML File
NMLCL001142
L6NonTuftedPyrRS.cell.nml
( view NeuroML )
NMLCH000140
ar__m00_25.channel.nml
( view NeuroML )
NMLCH000143
cal.channel.nml
( view NeuroML )
NMLCH000145
cat.channel.nml
( view NeuroML )
NMLCH000146
k2.channel.nml
( view NeuroML )
NMLCH000148
ka.channel.nml
( view NeuroML )
NMLCH000149
kahp_deeppyr.channel.nml
( view NeuroML )
NMLCH000153
kc.channel.nml
( view NeuroML )
NMLCH000155
kdr.channel.nml
( view NeuroML )
NMLCH000156
km.channel.nml
( view NeuroML )
NMLCH000157
naf__a0__b0__c0__d0__fastNa_shiftmin3_5.channel.nml
( view NeuroML )
NMLCH000164
nap.channel.nml
( view NeuroML )
NMLCH000172
pas.channel.nml
( view NeuroML )
NMLCN000011
cad__beta0_01__phi13000.nml
( view NeuroML )
NMLCN000012
cad__beta0_05__phi65000.nml
( view NeuroML )
Notes: None
Model Id: NMLCL001142
Associated Channels:
Associated Synapses: None
Associated Networks:
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Fast Spikers (FS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -72.64 mV
Rheobase Current Interval (0.95673, 0.96176] nA
Threshold Current Interval (1.23047, 1.28906] nA
Bias Current (to -80.00 mV) -0.4412 nA
Testing Temperature 6.3 °C
Stability Interval [-8.4375, 15.0] nA
AP 1-2 Amplitude Drop -6.1795 mV
AP 1 Steady State Amplitude Change -9.3716 mV
AP 1 Amplitude 70.3882 mV
AP 1 Width at Half Height 0.3500 ms
AP 1 Width (Peak To Trough) 0.7700 ms
AP 1 Rate of Change Peak to Trough -116.4956 mV/ms
AP 1 AHP Depth 19.3134 mV
AP2 Amplitude 76.5677 mV
AP2 Width at Half Height 0.4000 ms
AP 2 Width (Peak to Trough) 0.9900 ms
AP 2 Rate of Change Peak to Trough -88.5574 mV/ms
AP 2 AHP Depth 11.1042 mV
AP 1-2 Amplitude Change Percent 8.7792 %
AP 1-2 Half Width Change Percent 14.2857 %
AP 1-2 Rate of Change Peak to Trough Percent Change -23.9821 %
AP 1-2 AHP Depth Percent Change -42.5053 %
Input Resistance 12.6573 MΩ
AP 1 Delay Mean 1.7600 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 22.1200 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 12.8500 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -29.1667 %
Steady State Accommodation Mean -29.1667 %
Accommodation Rate to Steady State -0.0542 %/ms
Accommodation at Steady State Mean -61.2577 %
Accommodation Rate Mean at Steady State 147.7262 ms
ISI CV 5.4714
ISI Median 23.0900 ms
ISI Burst Mean Change -73.7721 %
Spike Rate (Strong Stimulation) 303.0000 Hz
AP 1 Delay Mean (Strong Stimulation) 1.6400 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 3.9900 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 1.8850 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2009.9400 ms
Frequency Filter Type Constant
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 0.0 µm2
Number of Stems 0.0
Number of Bifurcations 13.0
Number of Branches 27.0
Overall Width 300.791 µm
Overall Height 584.048 µm
Overall Depth 299.99 µm
Average Diameter 1.97487 µm
Total Length 2793.76 µm
Total Surface 14428.1 µm2
Total Volume 9592.13 µm3
Max Euclidean Distance 525.0 µm
Max Path Distance 525.0 µm
Max Branch Order 6.0
Average Contraction 0.991279
Total Fragmentation 113.0
Partition Asymmetry 0.458974
Average Rall's Ratio 1.857
Average Bifurcation Angle Local 115.038 °
Average Bifurcation Angle Remote 86.5441 °
Fractal Dimension 1.00073
Complexity Summary
State Equations 15647
Optimal Time-Step 0.00542 ms
Relative Complexity 5798.57 HH
Model Size
Sections 50
Compartments 1165
State Equations 15647
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00542 ms
Optimal Time-Step Error 0.66 %
Optimal Time-Step Benchmark Run Time 5798.57 HH
 
Maximum Stable Time-Step 0.03125 ms
Maximum Stable Time-Step Error 1.80 %
Max. Stable Time-Step Benchmark Run Time 15715.23 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 50980 Hz
CVODE Steps Per AP 195
CVODE Benchmark Run Time 10940.75 HH
Website & Images Copyright NeuroML © 2022 For questions: Contact us Links: Search Test |  ModelDB WS