Layer 5 Tufted Intrinsic Bursting (IB) Pyramidal Cell

Model Type:
Cell
Neurolex IDs: Pyramidal Cell
Keywords: muticompartment,soma,dendrites,axon,kainate,persistent gamma oscillations,thalamocortical sleep spindles,synchronized population bursts,electrographic seizures,isolated double population bursts with superimposed very fast oscillations,spike-wave,polyspike-wave,fast runs,epileptiform bursts,Electrical coupling
Publication: Traub, et. al. (2005) Single-column thalamocortical network model exhibiting gamma oscillations, sleep spindles, and epileptogenic bursts
Authors:
RD Traub   D Contreras   MO Cunningham   H Murray   FE LeBeau   A Roopun   A Bibbig   WB Wilent   MJ Higley   MA Whittington  
Translators: Padraig Gleeson   Eugenio Piasini   Chaitanya Chintaluri   Daniel Wojcik   Helena Glabska   Jacek Rogala   Michael Hines   Subhasis Ray   Tom├ís Alfonso   Yates Buckley  
Sources:
Files:
Model ID NeuroML File
NMLCL001140
L5TuftedPyrIB.cell.nml
( view NeuroML )
NMLCH000140
ar__m00_25.channel.nml
( view NeuroML )
NMLCH000143
cal.channel.nml
( view NeuroML )
NMLCH000145
cat.channel.nml
( view NeuroML )
NMLCH000146
k2.channel.nml
( view NeuroML )
NMLCH000147
ka_ib.channel.nml
( view NeuroML )
NMLCH000149
kahp_deeppyr.channel.nml
( view NeuroML )
NMLCH000153
kc.channel.nml
( view NeuroML )
NMLCH000155
kdr.channel.nml
( view NeuroML )
NMLCH000156
km.channel.nml
( view NeuroML )
NMLCH000157
naf__a0__b0__c0__d0__fastNa_shiftmin3_5.channel.nml
( view NeuroML )
NMLCH000164
nap.channel.nml
( view NeuroML )
NMLCH000172
pas.channel.nml
( view NeuroML )
NMLCN000008
cad__beta0_01__phi4333_33.nml
( view NeuroML )
NMLCN000009
cad__beta0_02__phi86666_7.nml
( view NeuroML )
NMLCN000010
cad__beta0_075__phi86666_7.nml
( view NeuroML )
Notes: None
Model Id: NMLCL001140
Associated Channels:
Associated Synapses: None
Associated Networks:
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Accommodating Fast Spikers (aFS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -77.15 mV
Rheobase Current Interval (1.12129, 1.12656] nA
Threshold Current Interval (1.28906, 1.34766] nA
Bias Current (to -70.00 mV) 0.4791 nA
Testing Temperature 6.3 °C
Stability Interval [-7.8125, 15.0] nA
AP 1-2 Amplitude Drop 13.3227 mV
AP 1 Steady State Amplitude Change 19.4089 mV
AP 1 Amplitude 82.1385 mV
AP 1 Width at Half Height 0.3100 ms
AP 1 Width (Peak To Trough) 0.8000 ms
AP 1 Rate of Change Peak to Trough -114.3061 mV/ms
AP 1 AHP Depth 9.3064 mV
AP2 Amplitude 68.8158 mV
AP2 Width at Half Height 0.4000 ms
AP 2 Width (Peak to Trough) 0.8800 ms
AP 2 Rate of Change Peak to Trough -92.8159 mV/ms
AP 2 AHP Depth 12.8622 mV
AP 1-2 Amplitude Change Percent -16.2198 %
AP 1-2 Half Width Change Percent 29.0323 %
AP 1-2 Rate of Change Peak to Trough Percent Change -18.8006 %
AP 1-2 AHP Depth Percent Change 38.2084 %
Input Resistance 14.8093 MΩ
AP 1 Delay Mean 1.7000 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 7.1600 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 28.3250 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean 5.0000 %
Steady State Accommodation Mean -5.0000 %
Accommodation Rate to Steady State -0.0857 %/ms
Accommodation at Steady State Mean -0.1595 %
Accommodation Rate Mean at Steady State 179344.2334 ms
ISI CV 0.6923
ISI Median 2.8700 ms
ISI Burst Mean Change 837.5458 %
Spike Rate (Strong Stimulation) 91.0000 Hz
AP 1 Delay Mean (Strong Stimulation) 3.1200 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 4.6000 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 1.9700 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2037.2600 ms
Frequency Filter Type Constant
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 0.0 µm2
Number of Stems 0.0
Number of Bifurcations 14.0
Number of Branches 29.0
Overall Width 305.352 µm
Overall Height 1316.82 µm
Overall Depth 270.0 µm
Average Diameter 2.06489 µm
Total Length 3790.85 µm
Total Surface 21302.7 µm2
Total Volume 15186.9 µm3
Max Euclidean Distance 1224.63 µm
Max Path Distance 1240.0 µm
Max Branch Order 6.0
Average Contraction 0.991655
Total Fragmentation 135.0
Partition Asymmetry 0.377539
Average Rall's Ratio 1.7
Average Bifurcation Angle Local 111.794 °
Average Bifurcation Angle Remote 66.886 °
Fractal Dimension 1.00072
Complexity Summary
State Equations 21251
Optimal Time-Step 0.00540 ms
Relative Complexity 6377.01 HH
Model Size
Sections 61
Compartments 1458
State Equations 21251
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00540 ms
Optimal Time-Step Error 0.57 %
Optimal Time-Step Benchmark Run Time 6377.01 HH
 
Maximum Stable Time-Step 0.03125 ms
Maximum Stable Time-Step Error 2.06 %
Max. Stable Time-Step Benchmark Run Time 17216.99 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 50405 Hz
CVODE Steps Per AP 264
CVODE Benchmark Run Time 12010.99 HH
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