Layer 4 Spiny Stellate Cell

Model Type:
Cell
Neurolex IDs: Pyramidal Cell
Keywords: multiple bursts,recurrent synaptic excitation,muticompartment,soma,dendrites,axon,kainate,persistent gamma oscillations,thalamocortical sleep spindles,synchronized population bursts,electrographic seizures,isolated double population bursts with superimposed very fast oscillations,spike-wave,polyspike-wave,fast runs,epileptiform bursts,Electrical coupling
Publication: Traub, et. al. (2005) Single-column thalamocortical network model exhibiting gamma oscillations, sleep spindles, and epileptogenic bursts
Authors:
RD Traub   D Contreras   MO Cunningham   H Murray   FE LeBeau   A Roopun   A Bibbig   WB Wilent   MJ Higley   MA Whittington  
Translators: Padraig Gleeson   Eugenio Piasini   Chaitanya Chintaluri   Daniel Wojcik   Helena Glabska   Jacek Rogala   Michael Hines   Subhasis Ray   Tom├ís Alfonso   Yates Buckley  
Sources:
Files:
Model ID NeuroML File
NMLCL001139
L4SpinyStellate.cell.nml
( view NeuroML )
NMLCH000141
ar__m00.channel.nml
( view NeuroML )
NMLCH000143
cal.channel.nml
( view NeuroML )
NMLCH000144
cat_a.channel.nml
( view NeuroML )
NMLCH000146
k2.channel.nml
( view NeuroML )
NMLCH000148
ka.channel.nml
( view NeuroML )
NMLCH000150
kahp_slower.channel.nml
( view NeuroML )
NMLCH000152
kc_fast.channel.nml
( view NeuroML )
NMLCH000154
kdr_fs.channel.nml
( view NeuroML )
NMLCH000156
km.channel.nml
( view NeuroML )
NMLCH000162
naf2__a0__b0__c0__d0__fastNa_shiftmin2_5.channel.nml
( view NeuroML )
NMLCH000167
napf_spinstell__a0__b0__c0__d0__shmin2_5.channel.nml
( view NeuroML )
NMLCH000172
pas.channel.nml
( view NeuroML )
NMLCN000003
cad__beta0_02__phi260000.nml
( view NeuroML )
NMLCN000007
cad__beta0_05__phi260000.nml
( view NeuroML )
Notes: None
Model Id: NMLCL001139
Associated Channels:
Associated Synapses: None
Associated Networks:
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Accommodating Fast Spikers (aFS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -71.11 mV
Rheobase Current Interval (0.23621, 0.23758] nA
Threshold Current Interval (0.29297, 0.35156] nA
Bias Current (to -80.00 mV) -0.3758 nA
Testing Temperature 6.3 °C
Stability Interval [-4.375, 15.0] nA
AP 1-2 Amplitude Drop -1.0055 mV
AP 1 Steady State Amplitude Change -3.1225 mV
AP 1 Amplitude 97.4103 mV
AP 1 Width at Half Height 0.3800 ms
AP 1 Width (Peak To Trough) 0.8100 ms
AP 1 Rate of Change Peak to Trough -134.5965 mV/ms
AP 1 AHP Depth 11.6129 mV
AP2 Amplitude 98.4159 mV
AP2 Width at Half Height 0.3900 ms
AP 2 Width (Peak to Trough) 0.8400 ms
AP 2 Rate of Change Peak to Trough -128.7319 mV/ms
AP 2 AHP Depth 9.7189 mV
AP 1-2 Amplitude Change Percent 1.0323 %
AP 1-2 Half Width Change Percent 2.6316 %
AP 1-2 Rate of Change Peak to Trough Percent Change -4.3572 %
AP 1-2 AHP Depth Percent Change -16.3093 %
Input Resistance 0.6311 MΩ
AP 1 Delay Mean 3.0400 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 9.8600 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 12.6400 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -41.6667 %
Steady State Accommodation Mean -33.3333 %
Accommodation Rate to Steady State -0.0556 %/ms
Accommodation at Steady State Mean -79.6961 %
Accommodation Rate Mean at Steady State 158.6333 ms
ISI CV 4.2942
ISI Median 55.3350 ms
ISI Burst Mean Change 170.6745 %
Spike Rate (Strong Stimulation) 174.0000 Hz
AP 1 Delay Mean (Strong Stimulation) 1.4400 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 2.7900 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 3.6050 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2026.8500 ms
Frequency Filter Type Constant
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 0.0 µm2
Number of Stems 0.0
Number of Bifurcations 13.0
Number of Branches 27.0
Overall Width 431.984 µm
Overall Height 380.116 µm
Overall Depth 432.0 µm
Average Diameter 1.45703 µm
Total Length 2425.15 µm
Total Surface 9240.12 µm2
Total Volume 6058.03 µm3
Max Euclidean Distance 332.385 µm
Max Path Distance 364.481 µm
Max Branch Order 6.0
Average Contraction 0.997837
Total Fragmentation 123.0
Partition Asymmetry 0.450916
Average Rall's Ratio 1.74889
Average Bifurcation Angle Local 88.162 °
Average Bifurcation Angle Remote 86.3708 °
Fractal Dimension 1.0
Complexity Summary
State Equations 16150
Optimal Time-Step 0.00372 ms
Relative Complexity 10113.86 HH
Model Size
Sections 59
Compartments 1214
State Equations 16150
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00372 ms
Optimal Time-Step Error 0.22 %
Optimal Time-Step Benchmark Run Time 10113.86 HH
 
Maximum Stable Time-Step 0.015625 ms
Maximum Stable Time-Step Error 0.82 %
Max. Stable Time-Step Benchmark Run Time 37623.36 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 89190 Hz
CVODE Steps Per AP 320
CVODE Benchmark Run Time 22857.40 HH
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