Superficial Layer 2/3 Regular Spiking (RS) Pyramidal Cell

Model Type:
Cell
Neurolex IDs: Neocortex pyramidal layer 2-3 cell,corticocortical cell, superficial pyramidal cell, Neocortex pyramidal neuron layer 2-3, Layer 2-3 pyramidal cell, Neocortical pyramidal neuron: superficial, deep layer (layer 5, 6) pyramidal cell
Keywords: muticompartment,soma,dendrites,axon,kainate,persistent gamma oscillations,thalamocortical sleep spindles,synchronized population bursts,electrographic seizures,isolated double population bursts with superimposed very fast oscillations,spike-wave,polyspike-wave,fast runs,epileptiform bursts,Electrical coupling
Publication: Traub, et. al. (2005) Single-column thalamocortical network model exhibiting gamma oscillations, sleep spindles, and epileptogenic bursts
Authors:
RD Traub   D Contreras   MO Cunningham   H Murray   FE LeBeau   A Roopun   A Bibbig   WB Wilent   MJ Higley   MA Whittington  
Translators: Padraig Gleeson   Eugenio Piasini   Chaitanya Chintaluri   Daniel Wojcik   Helena Glabska   Jacek Rogala   Michael Hines   Subhasis Ray   Tom├ís Alfonso   Yates Buckley  
Sources:
Files:
Model ID NeuroML File
NMLCL001138
L23PyrRS.cell.nml
( view NeuroML )
NMLCH000140
ar__m00_25.channel.nml
( view NeuroML )
NMLCH000143
cal.channel.nml
( view NeuroML )
NMLCH000145
cat.channel.nml
( view NeuroML )
NMLCH000146
k2.channel.nml
( view NeuroML )
NMLCH000148
ka.channel.nml
( view NeuroML )
NMLCH000151
kahp.channel.nml
( view NeuroML )
NMLCH000153
kc.channel.nml
( view NeuroML )
NMLCH000155
kdr.channel.nml
( view NeuroML )
NMLCH000156
km.channel.nml
( view NeuroML )
NMLCH000157
naf__a0__b0__c0__d0__fastNa_shiftmin3_5.channel.nml
( view NeuroML )
NMLCH000164
nap.channel.nml
( view NeuroML )
NMLCH000172
pas.channel.nml
( view NeuroML )
NMLCN000005
cad__beta0_01__phi26000.nml
( view NeuroML )
NMLCN000006
cad__beta0_05__phi52000.nml
( view NeuroML )
Notes: None
Model Id: NMLCL001138
Associated Channels:
Associated Synapses: None
Associated Networks:
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Non-accommodating Regular Spikers (naRS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -64.36 mV
Rheobase Current Interval (0.35706, 0.35934] nA
Threshold Current Interval (0.52734, 0.58594] nA
Bias Current (to -80.00 mV) -1.0101 nA
Testing Temperature 6.3 °C
Stability Interval [-6.25, 15.0] nA
AP 1-2 Amplitude Drop -0.5862 mV
AP 1 Steady State Amplitude Change -1.0921 mV
AP 1 Amplitude 79.1351 mV
AP 1 Width at Half Height 0.3500 ms
AP 1 Width (Peak To Trough) 9.5300 ms
AP 1 Rate of Change Peak to Trough -9.3992 mV/ms
AP 1 AHP Depth 10.4390 mV
AP2 Amplitude 79.7213 mV
AP2 Width at Half Height 0.3700 ms
AP 2 Width (Peak to Trough) 0.6600 ms
AP 2 Rate of Change Peak to Trough -125.5113 mV/ms
AP 2 AHP Depth 3.1162 mV
AP 1-2 Amplitude Change Percent 0.7408 %
AP 1-2 Half Width Change Percent 5.7143 %
AP 1-2 Rate of Change Peak to Trough Percent Change 1235.3444 %
AP 1-2 AHP Depth Percent Change -70.1489 %
Input Resistance 13.2687 MΩ
AP 1 Delay Mean 3.7100 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 82.7500 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 40.1850 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -33.3333 %
Steady State Accommodation Mean -33.3333 %
Accommodation Rate to Steady State -0.0554 %/ms
Accommodation at Steady State Mean -56.0200 %
Accommodation Rate Mean at Steady State 85.2386 ms
ISI CV 4.5035
ISI Median 93.3750 ms
ISI Burst Mean Change -98.3173 %
Spike Rate (Strong Stimulation) 35.0000 Hz
AP 1 Delay Mean (Strong Stimulation) 1.4900 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 16.8600 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 19.0100 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2292.5700 ms
Frequency Filter Type Constant
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 0.0 µm2
Number of Stems 0.0
Number of Bifurcations 21.0
Number of Branches 43.0
Overall Width 253.834 µm
Overall Height 528.805 µm
Overall Depth 228.92 µm
Average Diameter 1.92651 µm
Total Length 3667.89 µm
Total Surface 19285.5 µm2
Total Volume 15140.4 µm3
Max Euclidean Distance 408.965 µm
Max Path Distance 435.7 µm
Max Branch Order 9.0
Average Contraction 0.989567
Total Fragmentation 166.0
Partition Asymmetry 0.643915
Average Rall's Ratio 1.0975
Average Bifurcation Angle Local 96.6322 °
Average Bifurcation Angle Remote 79.0767 °
Fractal Dimension 1.00076
Complexity Summary
State Equations 15698
Optimal Time-Step 0.00587 ms
Relative Complexity 6496.65 HH
Model Size
Sections 74
Compartments 1042
State Equations 15698
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00587 ms
Optimal Time-Step Error 0.65 %
Optimal Time-Step Benchmark Run Time 6496.65 HH
 
Maximum Stable Time-Step 0.03125 ms
Maximum Stable Time-Step Error 0.91 %
Max. Stable Time-Step Benchmark Run Time 19049.57 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 45524 Hz
CVODE Steps Per AP 408
CVODE Benchmark Run Time 12428.08 HH
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