Superficial Layer 2/3 Fast Rhythmic Bursting (FRB) Pyramidal Cell

Model Type:
Cell
Neurolex IDs: Neocortex pyramidal layer 2-3 cell,corticocortical cell, superficial pyramidal cell, Neocortex pyramidal neuron layer 2-3, Layer 2-3 pyramidal cell, Neocortical pyramidal neuron: superficial, deep layer (layer 5, 6) pyramidal cell
Keywords: muticompartment,soma,dendrites,axon,kainate,persistent gamma oscillations,thalamocortical sleep spindles,synchronized population bursts,electrographic seizures,isolated double population bursts with superimposed very fast oscillations,spike-wave,polyspike-wave,fast runs,epileptiform bursts,Electrical coupling
Publication: Traub, et. al. (2005) Single-column thalamocortical network model exhibiting gamma oscillations, sleep spindles, and epileptogenic bursts
Authors:
RD Traub   D Contreras   MO Cunningham   H Murray   FE LeBeau   A Roopun   A Bibbig   WB Wilent   MJ Higley   MA Whittington  
Translators: Padraig Gleeson   Eugenio Piasini   Chaitanya Chintaluri   Daniel Wojcik   Helena Glabska   Jacek Rogala   Michael Hines   Subhasis Ray   Tom├ís Alfonso   Yates Buckley  
Sources:
Files:
Model ID NeuroML File
NMLCL001137
L23PyrFRB_varInit.cell.nml
( view NeuroML )
NMLCH000140
ar__m00_25.channel.nml
( view NeuroML )
NMLCH000143
cal.channel.nml
( view NeuroML )
NMLCH000145
cat.channel.nml
( view NeuroML )
NMLCH000146
k2.channel.nml
( view NeuroML )
NMLCH000148
ka.channel.nml
( view NeuroML )
NMLCH000151
kahp.channel.nml
( view NeuroML )
NMLCH000153
kc.channel.nml
( view NeuroML )
NMLCH000155
kdr.channel.nml
( view NeuroML )
NMLCH000156
km.channel.nml
( view NeuroML )
NMLCH000157
naf__a0__b0__c0__d0__fastNa_shiftmin3_5.channel.nml
( view NeuroML )
NMLCH000164
nap.channel.nml
( view NeuroML )
NMLCH000172
pas.channel.nml
( view NeuroML )
NMLCN000005
cad__beta0_01__phi26000.nml
( view NeuroML )
NMLCN000006
cad__beta0_05__phi52000.nml
( view NeuroML )
Notes: None
Model Id: NMLCL001137
Associated Channels:
Associated Synapses: None
Associated Networks:
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Non-Positive Rheobase (npRB)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking Yes
Resting Voltage N/A mV
Rheobase Current Interval (N/A, N/A] nA
Threshold Current Interval (N/A, N/A] nA
Bias Current (to N/A mV) N/A nA
Testing Temperature 6.3 °C
Stability Interval [-10.0, 15.0] nA
AP 1-2 Amplitude Drop N/A mV
AP 1 Steady State Amplitude Change N/A mV
AP 1 Amplitude N/A mV
AP 1 Width at Half Height N/A ms
AP 1 Width (Peak To Trough) N/A ms
AP 1 Rate of Change Peak to Trough N/A mV/ms
AP 1 AHP Depth N/A mV
AP2 Amplitude N/A mV
AP2 Width at Half Height N/A ms
AP 2 Width (Peak to Trough) N/A ms
AP 2 Rate of Change Peak to Trough N/A mV/ms
AP 2 AHP Depth N/A mV
AP 1-2 Amplitude Change Percent N/A %
AP 1-2 Half Width Change Percent N/A %
AP 1-2 Rate of Change Peak to Trough Percent Change N/A %
AP 1-2 AHP Depth Percent Change N/A %
Input Resistance N/A MΩ
AP 1 Delay Mean N/A ms
AP 1 Delay SD N/A ms
AP 2 Delay Mean N/A ms
AP 2 Delay SD N/A ms
Burst 1 ISI Mean N/A ms
Burst 1 ISI SD N/A ms
Initial Accommodation Mean N/A %
Steady State Accommodation Mean N/A %
Accommodation Rate to Steady State N/A %/ms
Accommodation at Steady State Mean N/A %
Accommodation Rate Mean at Steady State N/A ms
ISI CV N/A
ISI Median N/A ms
ISI Burst Mean Change N/A %
Spike Rate (Strong Stimulation) N/A Hz
AP 1 Delay Mean (Strong Stimulation) N/A ms
AP 1 Delay SD (Strong Stimulation) N/A ms
AP 2 Delay Mean (Strong Stimulation) N/A ms
AP 2 Delay SD (Strong Stimulation) N/A ms
Burst 1 ISI Mean (Strong Stimulation) N/A ms
Burst 1 ISI SD (Strong Stimulation) N/A ms
Ramp First Spike Time N/A ms
Frequency Filter Type N/A
Frequency Filter Pass Above N/A Hz
Frequency Filter Pass Below N/A Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 0.0 µm2
Number of Stems 0.0
Number of Bifurcations 21.0
Number of Branches 43.0
Overall Width 253.834 µm
Overall Height 528.805 µm
Overall Depth 228.92 µm
Average Diameter 1.92651 µm
Total Length 3667.89 µm
Total Surface 19285.5 µm2
Total Volume 15140.4 µm3
Max Euclidean Distance 408.965 µm
Max Path Distance 435.7 µm
Max Branch Order 9.0
Average Contraction 0.989567
Total Fragmentation 166.0
Partition Asymmetry 0.643915
Average Rall's Ratio 1.0975
Average Bifurcation Angle Local 96.6322 °
Average Bifurcation Angle Remote 79.0767 °
Fractal Dimension 1.00076
Complexity Summary
State Equations 11468
Optimal Time-Step N/A ms
Relative Complexity N/A HH
Model Size
Sections 74
Compartments 763
State Equations 11468
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step N/A ms
Optimal Time-Step Error N/A %
Optimal Time-Step Benchmark Run Time N/A HH
 
Maximum Stable Time-Step N/A ms
Maximum Stable Time-Step Error N/A %
Max. Stable Time-Step Benchmark Run Time N/A HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency N/A Hz
CVODE Steps Per AP N/A
CVODE Benchmark Run Time N/A HH
Website & Images Copyright NeuroML © 2022 For questions: Contact us Links: Search Test |  ModelDB WS