Main Olfactory Bulb Mitral Cell (5)

Model Type:
Cell
Neurolex IDs: Olfactory bulb (main) mitral cell
Keywords: main olfactory bulb, glutamate
Publication: Migliore, et. al. (2014) Distributed organization of a brain microcircuit analyzed by three-dimensional modeling: the olfactory bulb.
Authors:
Michele Migliore   Francesco Cavarretta   Michael Hines   Gordon Shepherd  
Translators: Padraig Gleeson   Justas Birgiolas  
Sources:
Files:
Model ID NeuroML File
NMLCL001133
Mitral_0_4.cell.nml
( view NeuroML )
NMLCH000134
kamt.channel.nml
( view NeuroML )
NMLCH000135
kdrmt.channel.nml
( view NeuroML )
NMLCH000136
nax__sh0.channel.nml
( view NeuroML )
NMLCH000137
nax__sh10.channel.nml
( view NeuroML )
NMLCH000139
pas.channel.nml
( view NeuroML )
Notes: None
Model Id: NMLCL001133
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Fast Spikers (FS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -67.24 mV
Rheobase Current Interval (0.60562, 0.61043] nA
Threshold Current Interval (1.17188, 1.23047] nA
Bias Current (to -80.00 mV) -0.7758 nA
Testing Temperature 35.0 °C
Stability Interval [-5.625, 15.0] nA
AP 1-2 Amplitude Drop -0.3150 mV
AP 1 Steady State Amplitude Change -0.1748 mV
AP 1 Amplitude 94.1736 mV
AP 1 Width at Half Height 1.4100 ms
AP 1 Width (Peak To Trough) 3.5300 ms
AP 1 Rate of Change Peak to Trough -33.9630 mV/ms
AP 1 AHP Depth 25.7157 mV
AP2 Amplitude 94.4886 mV
AP2 Width at Half Height 1.4100 ms
AP 2 Width (Peak to Trough) 3.6000 ms
AP 2 Rate of Change Peak to Trough -33.1692 mV/ms
AP 2 AHP Depth 24.9205 mV
AP 1-2 Amplitude Change Percent 0.3344 %
AP 1-2 Half Width Change Percent 0.0000 %
AP 1-2 Rate of Change Peak to Trough Percent Change -2.3373 %
AP 1-2 AHP Depth Percent Change -3.0926 %
Input Resistance 15.1454 MΩ
AP 1 Delay Mean 5.7600 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 74.1700 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 70.9750 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean 0.0000 %
Steady State Accommodation Mean 0.0000 %
Accommodation Rate to Steady State 0.0000 %/ms
Accommodation at Steady State Mean -6.9408 %
Accommodation Rate Mean at Steady State 0.5013 ms
ISI CV 76.0379
ISI Median 73.5100 ms
ISI Burst Mean Change 7.4989 %
Spike Rate (Strong Stimulation) 39.5000 Hz
AP 1 Delay Mean (Strong Stimulation) 1.4000 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 14.3400 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 17.7100 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2025.4200 ms
Frequency Filter Type Constant
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 69321.2 µm2
Number of Stems 6.0
Number of Bifurcations 21.0
Number of Branches 46.0
Overall Width 1124.65 µm
Overall Height 1512.8 µm
Overall Depth 898.18 µm
Average Diameter 2.86455 µm
Total Length 13173.9 µm
Total Surface 96642.5 µm2
Total Volume 76432.7 µm3
Max Euclidean Distance 1174.67 µm
Max Path Distance 1581.14 µm
Max Branch Order 4.0
Average Contraction 0.948054
Total Fragmentation 685.0
Partition Asymmetry 0.391775
Average Rall's Ratio 3.245
Average Bifurcation Angle Local 45.3302 °
Average Bifurcation Angle Remote 43.4899 °
Fractal Dimension 1.00955
Complexity Summary
State Equations 3960
Optimal Time-Step 0.00543 ms
Relative Complexity 2574.38 HH
Model Size
Sections 44
Compartments 660
State Equations 3960
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00543 ms
Optimal Time-Step Error 0.12 %
Optimal Time-Step Benchmark Run Time 2574.38 HH
 
Maximum Stable Time-Step 0.03125 ms
Maximum Stable Time-Step Error 1.04 %
Max. Stable Time-Step Benchmark Run Time 6992.94 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 17368 Hz
CVODE Steps Per AP 705
CVODE Benchmark Run Time 2245.75 HH
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