Main Olfactory Bulb Mitral Cell (4)

Model Type:
Cell
Neurolex IDs: Olfactory bulb (main) mitral cell
Keywords: main olfactory bulb, glutamate
Publication: Migliore, et. al. (2014) Distributed organization of a brain microcircuit analyzed by three-dimensional modeling: the olfactory bulb.
Authors:
Michele Migliore   Francesco Cavarretta   Michael Hines   Gordon Shepherd  
Translators: Justas Birgiolas   Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL001132
Mitral_0_3.cell.nml
( view NeuroML )
NMLCH000134
kamt.channel.nml
( view NeuroML )
NMLCH000135
kdrmt.channel.nml
( view NeuroML )
NMLCH000136
nax__sh0.channel.nml
( view NeuroML )
NMLCH000137
nax__sh10.channel.nml
( view NeuroML )
NMLCH000139
pas.channel.nml
( view NeuroML )
Notes: None
Model Id: NMLCL001132
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Fast Spikers (FS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -67.27 mV
Rheobase Current Interval (0.47607, 0.47974] nA
Threshold Current Interval (0.87891, 0.93750] nA
Bias Current (to -80.00 mV) -0.6154 nA
Testing Temperature 35.0 °C
Stability Interval [-4.375, 15.0] nA
AP 1-2 Amplitude Drop 0.7007 mV
AP 1 Steady State Amplitude Change 1.2279 mV
AP 1 Amplitude 95.5306 mV
AP 1 Width at Half Height 1.4100 ms
AP 1 Width (Peak To Trough) 3.5000 ms
AP 1 Rate of Change Peak to Trough -34.3335 mV/ms
AP 1 AHP Depth 24.6367 mV
AP2 Amplitude 94.8300 mV
AP2 Width at Half Height 1.4000 ms
AP 2 Width (Peak to Trough) 3.5400 ms
AP 2 Rate of Change Peak to Trough -33.8190 mV/ms
AP 2 AHP Depth 24.8892 mV
AP 1-2 Amplitude Change Percent -0.7334 %
AP 1-2 Half Width Change Percent -0.7092 %
AP 1-2 Rate of Change Peak to Trough Percent Change -1.4987 %
AP 1-2 AHP Depth Percent Change 1.0248 %
Input Resistance 19.2813 MΩ
AP 1 Delay Mean 5.3200 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 71.7500 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 69.1000 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -16.6667 %
Steady State Accommodation Mean -16.6667 %
Accommodation Rate to Steady State -0.1161 %/ms
Accommodation at Steady State Mean -7.3958 %
Accommodation Rate Mean at Steady State 1.0714 ms
ISI CV 71.3940
ISI Median 71.7300 ms
ISI Burst Mean Change 8.0385 %
Spike Rate (Strong Stimulation) 41.5000 Hz
AP 1 Delay Mean (Strong Stimulation) 1.2600 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 13.4900 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 16.4150 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2022.8600 ms
Frequency Filter Type Constant
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 8814.67 µm2
Number of Stems 6.0
Number of Bifurcations 17.0
Number of Branches 38.0
Overall Width 909.915 µm
Overall Height 1635.04 µm
Overall Depth 844.33 µm
Average Diameter 2.47594 µm
Total Length 11315.0 µm
Total Surface 80184.0 µm2
Total Volume 51826.6 µm3
Max Euclidean Distance 1072.81 µm
Max Path Distance 1317.93 µm
Max Branch Order 4.0
Average Contraction 0.934694
Total Fragmentation 594.0
Partition Asymmetry 0.63268
Average Rall's Ratio 1.445
Average Bifurcation Angle Local 55.6476 °
Average Bifurcation Angle Remote 51.9697 °
Fractal Dimension 1.00997
Complexity Summary
State Equations 3408
Optimal Time-Step 0.00547 ms
Relative Complexity 2120.90 HH
Model Size
Sections 35
Compartments 568
State Equations 3408
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00547 ms
Optimal Time-Step Error 0.14 %
Optimal Time-Step Benchmark Run Time 2120.90 HH
 
Maximum Stable Time-Step 0.03125 ms
Maximum Stable Time-Step Error 2.21 %
Max. Stable Time-Step Benchmark Run Time 5793.99 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 17793 Hz
CVODE Steps Per AP 678
CVODE Benchmark Run Time 1872.94 HH
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