Main Olfactory Bulb Mitral Cell (3)

Model Type:
Cell
Neurolex IDs: Olfactory bulb (main) mitral cell
Keywords: main olfactory bulb, glutamate
Publication: Migliore, et. al. (2014) Distributed organization of a brain microcircuit analyzed by three-dimensional modeling: the olfactory bulb.
Authors:
Michele Migliore   Francesco Cavarretta   Michael Hines   Gordon Shepherd  
Translators: Justas Birgiolas   Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL001131
Mitral_0_2.cell.nml
( view NeuroML )
NMLCH000134
kamt.channel.nml
( view NeuroML )
NMLCH000135
kdrmt.channel.nml
( view NeuroML )
NMLCH000136
nax__sh0.channel.nml
( view NeuroML )
NMLCH000137
nax__sh10.channel.nml
( view NeuroML )
NMLCH000139
pas.channel.nml
( view NeuroML )
Notes: None
Model Id: NMLCL001131
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Fast Spikers (FS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -67.27 mV
Rheobase Current Interval (0.40169, 0.40512] nA
Threshold Current Interval (0.82031, 0.87891] nA
Bias Current (to -80.00 mV) -0.5704 nA
Testing Temperature 35.0 °C
Stability Interval [-4.375, 15.0] nA
AP 1-2 Amplitude Drop 0.2795 mV
AP 1 Steady State Amplitude Change 0.1106 mV
AP 1 Amplitude 95.5443 mV
AP 1 Width at Half Height 1.3600 ms
AP 1 Width (Peak To Trough) 3.4500 ms
AP 1 Rate of Change Peak to Trough -35.3448 mV/ms
AP 1 AHP Depth 26.3952 mV
AP2 Amplitude 95.2648 mV
AP2 Width at Half Height 1.3600 ms
AP 2 Width (Peak to Trough) 3.4900 ms
AP 2 Rate of Change Peak to Trough -34.8364 mV/ms
AP 2 AHP Depth 26.3143 mV
AP 1-2 Amplitude Change Percent -0.2925 %
AP 1-2 Half Width Change Percent 0.0000 %
AP 1-2 Rate of Change Peak to Trough Percent Change -1.4382 %
AP 1-2 AHP Depth Percent Change -0.3062 %
Input Resistance 20.8086 MΩ
AP 1 Delay Mean 6.5100 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 78.7600 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 74.5550 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -16.6667 %
Steady State Accommodation Mean -16.6667 %
Accommodation Rate to Steady State -0.1071 %/ms
Accommodation at Steady State Mean -6.0123 %
Accommodation Rate Mean at Steady State 12.8642 ms
ISI CV 84.6798
ISI Median 76.8700 ms
ISI Burst Mean Change 6.3806 %
Spike Rate (Strong Stimulation) 35.5000 Hz
AP 1 Delay Mean (Strong Stimulation) 1.8000 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 16.2600 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 20.4100 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2023.6800 ms
Frequency Filter Type Constant
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 69322.0 µm2
Number of Stems 6.0
Number of Bifurcations 19.0
Number of Branches 42.0
Overall Width 1180.22 µm
Overall Height 1243.93 µm
Overall Depth 633.07 µm
Average Diameter 3.16213 µm
Total Length 8812.08 µm
Total Surface 66086.5 µm2
Total Volume 58312.3 µm3
Max Euclidean Distance 1034.25 µm
Max Path Distance 1221.13 µm
Max Branch Order 5.0
Average Contraction 0.945711
Total Fragmentation 467.0
Partition Asymmetry 0.507018
Average Rall's Ratio 2.63375
Average Bifurcation Angle Local 42.2234 °
Average Bifurcation Angle Remote 42.254 °
Fractal Dimension 1.00914
Complexity Summary
State Equations 2652
Optimal Time-Step 0.00549 ms
Relative Complexity 1537.41 HH
Model Size
Sections 40
Compartments 442
State Equations 2652
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00549 ms
Optimal Time-Step Error 0.10 %
Optimal Time-Step Benchmark Run Time 1537.41 HH
 
Maximum Stable Time-Step 0.03125 ms
Maximum Stable Time-Step Error 0.52 %
Max. Stable Time-Step Benchmark Run Time 4215.73 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 17469 Hz
CVODE Steps Per AP 641
CVODE Benchmark Run Time 1324.08 HH
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