Main Olfactory Bulb Mitral Cell (1)

Model Type:
Cell
Neurolex IDs: Olfactory bulb (main) mitral cell
Keywords: main olfactory bulb, glutamate
Publication: Migliore, et. al. (2014) Distributed organization of a brain microcircuit analyzed by three-dimensional modeling: the olfactory bulb.
Authors:
Michele Migliore   Francesco Cavarretta   Michael Hines   Gordon Shepherd  
Translators: Padraig Gleeson   Justas Birgiolas  
Sources:
Files:
Model ID NeuroML File
NMLCL001129
Mitral_0_0.cell.nml
( view NeuroML )
NMLCH000134
kamt.channel.nml
( view NeuroML )
NMLCH000135
kdrmt.channel.nml
( view NeuroML )
NMLCH000136
nax__sh0.channel.nml
( view NeuroML )
NMLCH000137
nax__sh10.channel.nml
( view NeuroML )
NMLCH000139
pas.channel.nml
( view NeuroML )
Notes: None
Model Id: NMLCL001129
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Fast Spikers (FS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -67.25 mV
Rheobase Current Interval (0.57838, 0.58273] nA
Threshold Current Interval (1.05469, 1.11328] nA
Bias Current (to -80.00 mV) -0.7106 nA
Testing Temperature 35.0 °C
Stability Interval [-5.0, 15.0] nA
AP 1-2 Amplitude Drop 0.8652 mV
AP 1 Steady State Amplitude Change 0.8747 mV
AP 1 Amplitude 95.3280 mV
AP 1 Width at Half Height 1.4300 ms
AP 1 Width (Peak To Trough) 3.4900 ms
AP 1 Rate of Change Peak to Trough -34.2424 mV/ms
AP 1 AHP Depth 24.1778 mV
AP2 Amplitude 94.4628 mV
AP2 Width at Half Height 1.4300 ms
AP 2 Width (Peak to Trough) 3.5500 ms
AP 2 Rate of Change Peak to Trough -33.5309 mV/ms
AP 2 AHP Depth 24.5719 mV
AP 1-2 Amplitude Change Percent -0.9076 %
AP 1-2 Half Width Change Percent -0.0000 %
AP 1-2 Rate of Change Peak to Trough Percent Change -2.0777 %
AP 1-2 AHP Depth Percent Change 1.6300 %
Input Resistance 16.6197 MΩ
AP 1 Delay Mean 5.0100 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 69.3500 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 67.1150 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean 0.0000 %
Steady State Accommodation Mean 0.0000 %
Accommodation Rate to Steady State 0.0000 %/ms
Accommodation at Steady State Mean -7.9735 %
Accommodation Rate Mean at Steady State 12.8840 ms
ISI CV 67.3848
ISI Median 69.9100 ms
ISI Burst Mean Change 8.6260 %
Spike Rate (Strong Stimulation) 43.5000 Hz
AP 1 Delay Mean (Strong Stimulation) 1.1800 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 12.9100 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 15.3400 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2018.6500 ms
Frequency Filter Type Constant
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 8814.77 µm2
Number of Stems 6.0
Number of Bifurcations 20.0
Number of Branches 44.0
Overall Width 1000.31 µm
Overall Height 1307.59 µm
Overall Depth 699.29 µm
Average Diameter 2.41249 µm
Total Length 13284.4 µm
Total Surface 92810.1 µm2
Total Volume 58451.4 µm3
Max Euclidean Distance 1211.19 µm
Max Path Distance 1597.92 µm
Max Branch Order 4.0
Average Contraction 0.950248
Total Fragmentation 692.0
Partition Asymmetry 0.529048
Average Rall's Ratio 2.75333
Average Bifurcation Angle Local 47.0114 °
Average Bifurcation Angle Remote 42.9532 °
Fractal Dimension 1.00948
Complexity Summary
State Equations 4002
Optimal Time-Step 0.00535 ms
Relative Complexity 2305.42 HH
Model Size
Sections 42
Compartments 667
State Equations 4002
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00535 ms
Optimal Time-Step Error 0.15 %
Optimal Time-Step Benchmark Run Time 2305.42 HH
 
Maximum Stable Time-Step 0.03125 ms
Maximum Stable Time-Step Error 0.77 %
Max. Stable Time-Step Benchmark Run Time 6168.38 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 17330 Hz
CVODE Steps Per AP 726
CVODE Benchmark Run Time 1995.38 HH
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