Main Olfactory Bulb Granule Cell

Model Type:
Cell
Neurolex IDs: Olfactory bulb (main) granule cell
Keywords: main olfactory bulb, gaba
Publication: Migliore, et. al. (2014) Distributed organization of a brain microcircuit analyzed by three-dimensional modeling: the olfactory bulb.
Authors:
Michele Migliore   Francesco Cavarretta   Michael Hines   Gordon Shepherd  
Translators: Padraig Gleeson   Justas Birgiolas  
Sources:
Files:
Model ID NeuroML File
NMLCL001128
Granule_0_110821.cell.nml
( view NeuroML )
NMLCH000134
kamt.channel.nml
( view NeuroML )
NMLCH000135
kdrmt.channel.nml
( view NeuroML )
NMLCH000138
nax__sh15.channel.nml
( view NeuroML )
NMLCH000139
pas.channel.nml
( view NeuroML )
Notes: None
Model Id: NMLCL001128
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Non-accommodating Regular Spikers (naRS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -67.58 mV
Rheobase Current Interval (0.02804, 0.02884] nA
Threshold Current Interval (0.15381, 0.20508] nA
Bias Current (to -80.00 mV) -0.0119 nA
Testing Temperature 35.0 °C
Stability Interval [-0.3125, 13.125] nA
AP 1-2 Amplitude Drop 2.5679 mV
AP 1 Steady State Amplitude Change 2.5366 mV
AP 1 Amplitude 62.8823 mV
AP 1 Width at Half Height 1.8800 ms
AP 1 Width (Peak To Trough) 13.9500 ms
AP 1 Rate of Change Peak to Trough -6.4962 mV/ms
AP 1 AHP Depth 27.7393 mV
AP2 Amplitude 60.3144 mV
AP2 Width at Half Height 2.0400 ms
AP 2 Width (Peak to Trough) 15.8000 ms
AP 2 Rate of Change Peak to Trough -5.6522 mV/ms
AP 2 AHP Depth 28.9902 mV
AP 1-2 Amplitude Change Percent -4.0836 %
AP 1-2 Half Width Change Percent 8.5106 %
AP 1-2 Rate of Change Peak to Trough Percent Change -12.9919 %
AP 1-2 AHP Depth Percent Change 4.5097 %
Input Resistance 1065.7851 MΩ
AP 1 Delay Mean 25.5800 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 116.0700 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 92.7050 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean 0.0000 %
Steady State Accommodation Mean 0.0000 %
Accommodation Rate to Steady State 0.0000 %/ms
Accommodation at Steady State Mean -4.6889 %
Accommodation Rate Mean at Steady State 17.8279 ms
ISI CV 97.6466
ISI Median 94.9400 ms
ISI Burst Mean Change 4.8956 %
Spike Rate (Strong Stimulation) 28.0000 Hz
AP 1 Delay Mean (Strong Stimulation) 7.3400 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 33.0500 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 30.1400 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2070.5300 ms
Frequency Filter Type Constant
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 1608.5 µm2
Number of Stems 1.0
Number of Bifurcations 2.0
Number of Branches 5.0
Overall Width 4.76837e-05 µm
Overall Height 394.858 µm
Overall Depth 0.0 µm
Average Diameter 1.96 µm
Total Length 563.742 µm
Total Surface 881.122 µm2
Total Volume 473.858 µm3
Max Euclidean Distance 405.858 µm
Max Path Distance 405.858 µm
Max Branch Order 2.0
Average Contraction 1.0
Total Fragmentation 10.0
Partition Asymmetry 0.5
Average Rall's Ratio 0.0
Average Bifurcation Angle Local 7.38946e-05 °
Average Bifurcation Angle Remote 5.68881e-05 °
Fractal Dimension 0.0
Complexity Summary
State Equations 211
Optimal Time-Step 0.00542 ms
Relative Complexity 89.15 HH
Model Size
Sections 5
Compartments 42
State Equations 211
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00542 ms
Optimal Time-Step Error 0.15 %
Optimal Time-Step Benchmark Run Time 89.15 HH
 
Maximum Stable Time-Step 0.03125 ms
Maximum Stable Time-Step Error 1.60 %
Max. Stable Time-Step Benchmark Run Time 241.46 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 15958 Hz
CVODE Steps Per AP 654
CVODE Benchmark Run Time 71.45 HH
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