Intrinsically Repetitive Bursting (IBR) Cell

Model Type:
Cell
Neurolex IDs: None
Keywords: neocortex, minimal models, Neuron or other electrically excitable cell, Channel/Receptor, Parameter Fitting, Simplified Models
Publication: Pospischil, et. al. (2008) Minimal Hodgkin-Huxley type models for different classes of cortical and thalamic neurons.
Authors:
Martin Pospischil   Maria Toledo-Rodriguez   Cyril Monier   Zuzanna Piwkowska   Thierry Bal   Yves Fr├ęgnac   H Markram   Alain Destexhe  
Translators: Padraig Gleeson   Justas Birgiolas  
Sources:
Files:
Notes: None
Model Id: NMLCL001125
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Accommodating Fast Spikers (aFS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -85.29 mV
Rheobase Current Interval (0.09613, 0.10986] nA
Threshold Current Interval (3.45703, 3.51562] nA
Bias Current (to -80.00 mV) 0.0164 nA
Testing Temperature 36.0 °C
Stability Interval [-10.0, 15.0] nA
AP 1-2 Amplitude Drop 3.0048 mV
AP 1 Steady State Amplitude Change -0.5679 mV
AP 1 Amplitude 87.9515 mV
AP 1 Width at Half Height 0.7100 ms
AP 1 Width (Peak To Trough) 1.6100 ms
AP 1 Rate of Change Peak to Trough -65.3317 mV/ms
AP 1 AHP Depth 17.2324 mV
AP2 Amplitude 84.9467 mV
AP2 Width at Half Height 0.6600 ms
AP 2 Width (Peak to Trough) 1.5200 ms
AP 2 Rate of Change Peak to Trough -65.6047 mV/ms
AP 2 AHP Depth 14.7724 mV
AP 1-2 Amplitude Change Percent -3.4165 %
AP 1-2 Half Width Change Percent -7.0423 %
AP 1-2 Rate of Change Peak to Trough Percent Change 0.4179 %
AP 1-2 AHP Depth Percent Change -14.2755 %
Input Resistance 341.6915 MΩ
AP 1 Delay Mean 100.0500 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 104.6200 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 4.4650 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -88.4615 %
Steady State Accommodation Mean -96.1538 %
Accommodation Rate to Steady State N/A %/ms
Accommodation at Steady State Mean -100.0004 %
Accommodation Rate Mean at Steady State 3587493.0450 ms
ISI CV 0.4278
ISI Median 6.3300 ms
ISI Burst Mean Change -4.5952 %
Spike Rate (Strong Stimulation) 47.5000 Hz
AP 1 Delay Mean (Strong Stimulation) 40.2300 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 44.4700 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 4.1250 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2196.4800 ms
Frequency Filter Type Constant
Single compartment, abstract, or point cells do not have morphology data.
Complexity Summary
Relative Complexity 2.79 HH
State Equations 8
Optimal Time-Step 0.00931 ms
Model Size
Sections 1
Compartments 1
State Equations 8
Variable Time-Step Complexity
CVODE Steady State Step Frequency 17739 Hz
CVODE Steps Per AP 259
CVODE Benchmark Run Time 2.79 HH
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