Intrinsically Bursting (IB) Cell

Model Type:
Cell
Neurolex IDs: None
Keywords: neocortex, minimal models, Neuron or other electrically excitable cell, Channel/Receptor, Parameter Fitting, Simplified Models
Publication: Pospischil, et. al. (2008) Minimal Hodgkin-Huxley type models for different classes of cortical and thalamic neurons.
Authors:
Martin Pospischil   Maria Toledo-Rodriguez   Cyril Monier   Zuzanna Piwkowska   Thierry Bal   Yves Fr├ęgnac   H Markram   Alain Destexhe  
Translators: Padraig Gleeson   Justas Birgiolas  
Sources:
Files:
Notes: None
Model Id: NMLCL001124
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Delayed Regular Spikers (dRS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -85.29 mV
Rheobase Current Interval (0.09613, 0.10986] nA
Threshold Current Interval (3.45703, 3.51562] nA
Bias Current (to -80.00 mV) 0.0164 nA
Testing Temperature 36.0 °C
Stability Interval [-10.0, 15.0] nA
AP 1-2 Amplitude Drop 0.9310 mV
AP 1 Steady State Amplitude Change -0.4538 mV
AP 1 Amplitude 87.8303 mV
AP 1 Width at Half Height 0.7000 ms
AP 1 Width (Peak To Trough) 1.6600 ms
AP 1 Rate of Change Peak to Trough -64.6771 mV/ms
AP 1 AHP Depth 19.5337 mV
AP2 Amplitude 86.8993 mV
AP2 Width at Half Height 0.6800 ms
AP 2 Width (Peak to Trough) 1.6200 ms
AP 2 Rate of Change Peak to Trough -65.2405 mV/ms
AP 2 AHP Depth 18.7903 mV
AP 1-2 Amplitude Change Percent -1.0600 %
AP 1-2 Half Width Change Percent -2.8571 %
AP 1-2 Rate of Change Peak to Trough Percent Change 0.8710 %
AP 1-2 AHP Depth Percent Change -3.8060 %
Input Resistance 341.6915 MΩ
AP 1 Delay Mean 100.0700 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 107.2800 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 7.0500 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -87.5000 %
Steady State Accommodation Mean -75.0000 %
Accommodation Rate to Steady State -0.1354 %/ms
Accommodation at Steady State Mean -111.0933 %
Accommodation Rate Mean at Steady State 143.1811 ms
ISI CV 1.0175
ISI Median 115.3800 ms
ISI Burst Mean Change -4.4383 %
Spike Rate (Strong Stimulation) 32.0000 Hz
AP 1 Delay Mean (Strong Stimulation) 40.2300 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 45.9700 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 5.5900 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2196.7800 ms
Frequency Filter Type Low-Pass
Frequency Filter Pass Below 54.6162 Hz
Single compartment, abstract, or point cells do not have morphology data.
Complexity Summary
Relative Complexity 2.83 HH
State Equations 8
Optimal Time-Step 0.00880 ms
Model Size
Sections 1
Compartments 1
State Equations 8
Variable Time-Step Complexity
CVODE Steady State Step Frequency 17602 Hz
CVODE Steps Per AP 274
CVODE Benchmark Run Time 2.83 HH
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