Layer 6 Delayed Stuttering Nest Basket Cell (2)

Model Type:
Cell
Neurolex IDs: Neocortex basket cell
Neocortex Layer 6
Keywords: delayed stuttering,Layer 6,Fast-spiking, interneuron, GABAergic, inhibitory, neocortex, rat, somatosensory cortex, nest, basket
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL001118
dSTUT214_L6_NBC_242af4db7d_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000106
KdShu2007.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCH000115
StochKv_deterministic.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL001118
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Fast Spikers (FS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -75.28 mV
Rheobase Current Interval (0.08240, 0.08308] nA
Threshold Current Interval (0.11719, 0.17578] nA
Bias Current (to -70.00 mV) 0.0155 nA
Testing Temperature 34.0 °C
Stability Interval [-0.625, 15.0] nA
AP 1-2 Amplitude Drop 3.6956 mV
AP 1 Steady State Amplitude Change 4.6757 mV
AP 1 Amplitude 78.6534 mV
AP 1 Width at Half Height 0.6200 ms
AP 1 Width (Peak To Trough) 3.0100 ms
AP 1 Rate of Change Peak to Trough -33.1005 mV/ms
AP 1 AHP Depth 20.9792 mV
AP2 Amplitude 74.9578 mV
AP2 Width at Half Height 0.6300 ms
AP 2 Width (Peak to Trough) 3.0300 ms
AP 2 Rate of Change Peak to Trough -31.6322 mV/ms
AP 2 AHP Depth 20.8878 mV
AP 1-2 Amplitude Change Percent -4.6985 %
AP 1-2 Half Width Change Percent 1.6129 %
AP 1-2 Rate of Change Peak to Trough Percent Change -4.4358 %
AP 1-2 AHP Depth Percent Change -0.4354 %
Input Resistance 511.2485 MΩ
AP 1 Delay Mean 5.3200 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 23.6300 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 19.3050 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -5.0000 %
Steady State Accommodation Mean -10.0000 %
Accommodation Rate to Steady State -0.0126 %/ms
Accommodation at Steady State Mean -18.2771 %
Accommodation Rate Mean at Steady State 2284.5790 ms
ISI CV 27.4309
ISI Median 21.2000 ms
ISI Burst Mean Change 10.8684 %
Spike Rate (Strong Stimulation) 81.0000 Hz
AP 1 Delay Mean (Strong Stimulation) 2.3500 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 12.3400 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 10.9000 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2125.7600 ms
Frequency Filter Type Low-Pass
Frequency Filter Pass Below 69.3250 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 3574.64 µm2
Number of Stems 10.0
Number of Bifurcations 15.0
Number of Branches 39.0
Overall Width 287.878 µm
Overall Height 268.067 µm
Overall Depth 134.52 µm
Average Diameter 0.538426 µm
Total Length 2375.05 µm
Total Surface 3353.85 µm2
Total Volume 1288.38 µm3
Max Euclidean Distance 215.909 µm
Max Path Distance 253.253 µm
Max Branch Order 4.0
Average Contraction 0.966597
Total Fragmentation 1198.0
Partition Asymmetry 0.266667
Average Rall's Ratio 1.58444
Average Bifurcation Angle Local 53.8032 °
Average Bifurcation Angle Remote 56.8307 °
Fractal Dimension 1.00633
Complexity Summary
State Equations 1601
Optimal Time-Step 0.00538 ms
Relative Complexity 509.10 HH
Model Size
Sections 40
Compartments 122
State Equations 1601
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00538 ms
Optimal Time-Step Error 0.25 %
Optimal Time-Step Benchmark Run Time 509.10 HH
 
Maximum Stable Time-Step 0.03125 ms
Maximum Stable Time-Step Error 1.21 %
Max. Stable Time-Step Benchmark Run Time 1368.18 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 16575 Hz
CVODE Steps Per AP 296
CVODE Benchmark Run Time 351.65 HH
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