Layer 6 Delayed Stuttering Bipolar Cell (1)

Model Type:
Cell
Neurolex IDs: Bipolar Cell
Neocortex Layer 6
Keywords: delayed stuttering,Layer 6,GABAergic, inhibitory, neocortex, rat, somatosensory cortex, bipolar
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL001112
dSTUT214_L6_BP_82b6294190_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000106
KdShu2007.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCH000115
StochKv_deterministic.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL001112
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Fast Spikers (FS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -75.93 mV
Rheobase Current Interval (0.10803, 0.10895] nA
Threshold Current Interval (0.17578, 0.23438] nA
Bias Current (to -70.00 mV) 0.0246 nA
Testing Temperature 34.0 °C
Stability Interval [-0.9375, 15.0] nA
AP 1-2 Amplitude Drop 4.1276 mV
AP 1 Steady State Amplitude Change 3.9404 mV
AP 1 Amplitude 76.7451 mV
AP 1 Width at Half Height 0.6100 ms
AP 1 Width (Peak To Trough) 2.4600 ms
AP 1 Rate of Change Peak to Trough -36.1347 mV/ms
AP 1 AHP Depth 12.1463 mV
AP2 Amplitude 72.6176 mV
AP2 Width at Half Height 0.6200 ms
AP 2 Width (Peak to Trough) 2.6500 ms
AP 2 Rate of Change Peak to Trough -32.2087 mV/ms
AP 2 AHP Depth 12.7354 mV
AP 1-2 Amplitude Change Percent -5.3783 %
AP 1-2 Half Width Change Percent 1.6393 %
AP 1-2 Rate of Change Peak to Trough Percent Change -10.8650 %
AP 1-2 AHP Depth Percent Change 4.8504 %
Input Resistance 296.3135 MΩ
AP 1 Delay Mean 5.9700 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 21.5900 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 16.9300 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean 4.3478 %
Steady State Accommodation Mean 4.3478 %
Accommodation Rate to Steady State 0.1092 %/ms
Accommodation at Steady State Mean -0.0000 %
Accommodation Rate Mean at Steady State 59.5732 ms
ISI CV 32.8434
ISI Median 16.5900 ms
ISI Burst Mean Change 16.7734 %
Spike Rate (Strong Stimulation) 113.5000 Hz
AP 1 Delay Mean (Strong Stimulation) 1.8300 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 9.7100 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 8.4900 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2067.5000 ms
Frequency Filter Type Constant
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 1850.73 µm2
Number of Stems 5.0
Number of Bifurcations 30.0
Number of Branches 64.0
Overall Width 339.63 µm
Overall Height 451.644 µm
Overall Depth 206.18 µm
Average Diameter 0.633331 µm
Total Length 3599.34 µm
Total Surface 6363.67 µm2
Total Volume 1344.46 µm3
Max Euclidean Distance 320.878 µm
Max Path Distance 390.994 µm
Max Branch Order 6.0
Average Contraction 0.972188
Total Fragmentation 1022.0
Partition Asymmetry 0.369444
Average Rall's Ratio 1.11375
Average Bifurcation Angle Local 33.0199 °
Average Bifurcation Angle Remote 49.1721 °
Fractal Dimension 1.00557
Complexity Summary
State Equations 2420
Optimal Time-Step 0.00773 ms
Relative Complexity 521.45 HH
Model Size
Sections 65
Compartments 185
State Equations 2420
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00773 ms
Optimal Time-Step Error 0.36 %
Optimal Time-Step Benchmark Run Time 521.45 HH
 
Maximum Stable Time-Step 0.0625 ms
Maximum Stable Time-Step Error 2.00 %
Max. Stable Time-Step Benchmark Run Time 1007.30 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 17521 Hz
CVODE Steps Per AP 252
CVODE Benchmark Run Time 531.21 HH
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