Layer 5 Delayed Stuttering Nest Basket Cell (1)

Model Type:
Cell
Neurolex IDs: Neocortex basket cell
Neocortex Layer 5
Keywords: delayed stuttering,Layer 5,Fast-spiking, interneuron, GABAergic, inhibitory, neocortex, rat, somatosensory cortex, nest, basket
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL001107
dSTUT214_L5_NBC_2518b7a9e0_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000106
KdShu2007.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCH000115
StochKv_deterministic.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL001107
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Fast Spikers (FS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -75.09 mV
Rheobase Current Interval (0.18265, 0.18425] nA
Threshold Current Interval (0.35156, 0.41016] nA
Bias Current (to -70.00 mV) 0.0371 nA
Testing Temperature 34.0 °C
Stability Interval [-1.875, 15.0] nA
AP 1-2 Amplitude Drop 3.3717 mV
AP 1 Steady State Amplitude Change 3.3990 mV
AP 1 Amplitude 85.7777 mV
AP 1 Width at Half Height 0.5600 ms
AP 1 Width (Peak To Trough) 2.5300 ms
AP 1 Rate of Change Peak to Trough -42.5458 mV/ms
AP 1 AHP Depth 21.8633 mV
AP2 Amplitude 82.4059 mV
AP2 Width at Half Height 0.5300 ms
AP 2 Width (Peak to Trough) 2.5100 ms
AP 2 Rate of Change Peak to Trough -41.5684 mV/ms
AP 2 AHP Depth 21.9307 mV
AP 1-2 Amplitude Change Percent -3.9308 %
AP 1-2 Half Width Change Percent -5.3571 %
AP 1-2 Rate of Change Peak to Trough Percent Change -2.2974 %
AP 1-2 AHP Depth Percent Change 0.3086 %
Input Resistance 181.3713 MΩ
AP 1 Delay Mean 5.6400 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 25.4000 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 20.5650 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean 0.0000 %
Steady State Accommodation Mean 0.0000 %
Accommodation Rate to Steady State 0.0000 %/ms
Accommodation at Steady State Mean -6.5460 %
Accommodation Rate Mean at Steady State 0.2581 ms
ISI CV 78.5742
ISI Median 21.1450 ms
ISI Burst Mean Change 8.1478 %
Spike Rate (Strong Stimulation) 81.5000 Hz
AP 1 Delay Mean (Strong Stimulation) 1.9500 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 12.3500 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 11.3050 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2072.5800 ms
Frequency Filter Type Low-Pass
Frequency Filter Pass Below 93.2680 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 7113.43 µm2
Number of Stems 7.0
Number of Bifurcations 32.0
Number of Branches 70.0
Overall Width 289.811 µm
Overall Height 600.958 µm
Overall Depth 151.13 µm
Average Diameter 0.826183 µm
Total Length 4367.2 µm
Total Surface 9951.0 µm2
Total Volume 3947.69 µm3
Max Euclidean Distance 470.663 µm
Max Path Distance 565.794 µm
Max Branch Order 6.0
Average Contraction 0.956798
Total Fragmentation 2463.0
Partition Asymmetry 0.535417
Average Rall's Ratio 0.879545
Average Bifurcation Angle Local 34.0317 °
Average Bifurcation Angle Remote 52.8782 °
Fractal Dimension 1.0086
Complexity Summary
State Equations 2888
Optimal Time-Step 0.00771 ms
Relative Complexity 668.51 HH
Model Size
Sections 71
Compartments 221
State Equations 2888
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00771 ms
Optimal Time-Step Error 0.28 %
Optimal Time-Step Benchmark Run Time 668.51 HH
 
Maximum Stable Time-Step 0.0625 ms
Maximum Stable Time-Step Error 1.83 %
Max. Stable Time-Step Benchmark Run Time 1288.24 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 18952 Hz
CVODE Steps Per AP 256
CVODE Benchmark Run Time 729.07 HH
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