Layer 5 Delayed Stuttering Large Basket Cell (4)

Model Type:
Cell
Neurolex IDs: Neocortex basket cell
Neocortex Layer 5
Keywords: delayed stuttering,Layer 5,Fast-spiking, interneuron, GABAergic, inhibitory, neocortex, rat, somatosensory cortex, large, basket
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL001105
dSTUT214_L5_LBC_a7bdd51160_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000106
KdShu2007.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCH000115
StochKv_deterministic.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL001105
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Fast Spikers (FS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -75.29 mV
Rheobase Current Interval (0.21950, 0.22110] nA
Threshold Current Interval (0.35156, 0.41016] nA
Bias Current (to -70.00 mV) 0.0398 nA
Testing Temperature 34.0 °C
Stability Interval [-1.25, 15.0] nA
AP 1-2 Amplitude Drop 6.9223 mV
AP 1 Steady State Amplitude Change 7.4623 mV
AP 1 Amplitude 79.1701 mV
AP 1 Width at Half Height 0.5700 ms
AP 1 Width (Peak To Trough) 2.4500 ms
AP 1 Rate of Change Peak to Trough -40.8498 mV/ms
AP 1 AHP Depth 20.9119 mV
AP2 Amplitude 72.2478 mV
AP2 Width at Half Height 0.5800 ms
AP 2 Width (Peak to Trough) 2.4800 ms
AP 2 Rate of Change Peak to Trough -37.9327 mV/ms
AP 2 AHP Depth 21.8254 mV
AP 1-2 Amplitude Change Percent -8.7436 %
AP 1-2 Half Width Change Percent 1.7544 %
AP 1-2 Rate of Change Peak to Trough Percent Change -7.1409 %
AP 1-2 AHP Depth Percent Change 4.3685 %
Input Resistance 190.0428 MΩ
AP 1 Delay Mean 4.3300 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 22.3600 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 19.2350 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean 0.0000 %
Steady State Accommodation Mean -5.0000 %
Accommodation Rate to Steady State -0.1168 %/ms
Accommodation at Steady State Mean -11.6018 %
Accommodation Rate Mean at Steady State 0.3869 ms
ISI CV 42.4014
ISI Median 20.4000 ms
ISI Burst Mean Change 13.3666 %
Spike Rate (Strong Stimulation) 87.0000 Hz
AP 1 Delay Mean (Strong Stimulation) 1.8800 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 11.2300 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 10.2800 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2145.8800 ms
Frequency Filter Type Low-Pass
Frequency Filter Pass Below 93.2979 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 15421.5 µm2
Number of Stems 9.0
Number of Bifurcations 36.0
Number of Branches 80.0
Overall Width 560.496 µm
Overall Height 610.822 µm
Overall Depth 354.08 µm
Average Diameter 0.579111 µm
Total Length 7937.9 µm
Total Surface 9767.61 µm2
Total Volume 5662.53 µm3
Max Euclidean Distance 446.505 µm
Max Path Distance 508.938 µm
Max Branch Order 6.0
Average Contraction 0.960152
Total Fragmentation 2219.0
Partition Asymmetry 0.496693
Average Rall's Ratio 1.06525
Average Bifurcation Angle Local 23.1678 °
Average Bifurcation Angle Remote 50.0268 °
Fractal Dimension 1.00752
Complexity Summary
State Equations 5306
Optimal Time-Step 0.00759 ms
Relative Complexity 1261.97 HH
Model Size
Sections 81
Compartments 407
State Equations 5306
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00759 ms
Optimal Time-Step Error 0.52 %
Optimal Time-Step Benchmark Run Time 1261.97 HH
 
Maximum Stable Time-Step 0.0625 ms
Maximum Stable Time-Step Error 3.33 %
Max. Stable Time-Step Benchmark Run Time 2392.55 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 20176 Hz
CVODE Steps Per AP 232
CVODE Benchmark Run Time 1415.95 HH
Website & Images Copyright NeuroML © 2020 For questions: Contact us Links: Search Test |  ModelDB WS