Layer 5 Delayed Stuttering Large Basket Cell (2)

Model Type:
Cell
Neurolex IDs: Neocortex basket cell
Neocortex Layer 5
Keywords: delayed stuttering,Layer 5,Fast-spiking, interneuron, GABAergic, inhibitory, neocortex, rat, somatosensory cortex, large, basket
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL001103
dSTUT214_L5_LBC_6a6d472ca8_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000106
KdShu2007.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCH000115
StochKv_deterministic.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL001103
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Fast Spikers (FS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -74.17 mV
Rheobase Current Interval (0.10620, 0.10712] nA
Threshold Current Interval (0.17578, 0.23438] nA
Bias Current (to -80.00 mV) -0.0196 nA
Testing Temperature 34.0 °C
Stability Interval [-0.625, 15.0] nA
AP 1-2 Amplitude Drop 7.9091 mV
AP 1 Steady State Amplitude Change 8.0063 mV
AP 1 Amplitude 88.0029 mV
AP 1 Width at Half Height 0.4700 ms
AP 1 Width (Peak To Trough) 2.1100 ms
AP 1 Rate of Change Peak to Trough -53.9816 mV/ms
AP 1 AHP Depth 25.8982 mV
AP2 Amplitude 80.0938 mV
AP2 Width at Half Height 0.4300 ms
AP 2 Width (Peak to Trough) 2.0600 ms
AP 2 Rate of Change Peak to Trough -52.5504 mV/ms
AP 2 AHP Depth 28.1600 mV
AP 1-2 Amplitude Change Percent -8.9873 %
AP 1-2 Half Width Change Percent -8.5106 %
AP 1-2 Rate of Change Peak to Trough Percent Change -2.6513 %
AP 1-2 AHP Depth Percent Change 8.7333 %
Input Resistance 388.2376 MΩ
AP 1 Delay Mean 4.0400 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 31.4500 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 27.5400 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -13.3333 %
Steady State Accommodation Mean -20.0000 %
Accommodation Rate to Steady State -0.0238 %/ms
Accommodation at Steady State Mean -21.3546 %
Accommodation Rate Mean at Steady State 1017.7967 ms
ISI CV 16.8495
ISI Median 31.3650 ms
ISI Burst Mean Change 0.9486 %
Spike Rate (Strong Stimulation) 64.5000 Hz
AP 1 Delay Mean (Strong Stimulation) 1.7400 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 13.7300 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 13.1400 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2259.3900 ms
Frequency Filter Type Low-Pass
Frequency Filter Pass Below 51.9968 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 15563.3 µm2
Number of Stems 9.0
Number of Bifurcations 6.0
Number of Branches 20.0
Overall Width 283.185 µm
Overall Height 225.088 µm
Overall Depth 38.3 µm
Average Diameter 0.782974 µm
Total Length 1382.5 µm
Total Surface 3302.98 µm2
Total Volume 4363.24 µm3
Max Euclidean Distance 230.304 µm
Max Path Distance 283.07 µm
Max Branch Order 2.0
Average Contraction 0.924722
Total Fragmentation 1036.0
Partition Asymmetry 0.333333
Average Rall's Ratio 0.707
Average Bifurcation Angle Local 1.06596e-06 °
Average Bifurcation Angle Remote 58.3038 °
Fractal Dimension 1.01521
Complexity Summary
State Equations 860
Optimal Time-Step 0.00791 ms
Relative Complexity 202.01 HH
Model Size
Sections 21
Compartments 65
State Equations 860
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00791 ms
Optimal Time-Step Error 0.33 %
Optimal Time-Step Benchmark Run Time 202.01 HH
 
Maximum Stable Time-Step 0.0625 ms
Maximum Stable Time-Step Error 2.92 %
Max. Stable Time-Step Benchmark Run Time 399.31 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 18867 Hz
CVODE Steps Per AP 382
CVODE Benchmark Run Time 238.34 HH
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