Layer 5 Delayed Stuttering Large Basket Cell (1)

Model Type:
Cell
Neurolex IDs: Neocortex basket cell
Neocortex Layer 5
Keywords: delayed stuttering,Layer 5,Fast-spiking, interneuron, GABAergic, inhibitory, neocortex, rat, somatosensory cortex, large, basket
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL001102
dSTUT214_L5_LBC_5dc27443f3_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000106
KdShu2007.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCH000115
StochKv_deterministic.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL001102
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Fast Spikers (FS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -75.32 mV
Rheobase Current Interval (0.10437, 0.10529] nA
Threshold Current Interval (0.17578, 0.23438] nA
Bias Current (to -70.00 mV) 0.0214 nA
Testing Temperature 34.0 °C
Stability Interval [-0.625, 15.0] nA
AP 1-2 Amplitude Drop 3.6016 mV
AP 1 Steady State Amplitude Change 3.7488 mV
AP 1 Amplitude 78.1807 mV
AP 1 Width at Half Height 0.5700 ms
AP 1 Width (Peak To Trough) 2.7500 ms
AP 1 Rate of Change Peak to Trough -35.3613 mV/ms
AP 1 AHP Depth 19.0629 mV
AP2 Amplitude 74.5791 mV
AP2 Width at Half Height 0.5900 ms
AP 2 Width (Peak to Trough) 2.8300 ms
AP 2 Rate of Change Peak to Trough -33.0603 mV/ms
AP 2 AHP Depth 18.9815 mV
AP 1-2 Amplitude Change Percent -4.6067 %
AP 1-2 Half Width Change Percent 3.5088 %
AP 1-2 Rate of Change Peak to Trough Percent Change -6.5071 %
AP 1-2 AHP Depth Percent Change -0.4269 %
Input Resistance 346.2996 MΩ
AP 1 Delay Mean 5.1500 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 22.7000 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 18.6250 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -4.7619 %
Steady State Accommodation Mean -4.7619 %
Accommodation Rate to Steady State -0.1123 %/ms
Accommodation at Steady State Mean -10.5819 %
Accommodation Rate Mean at Steady State 0.0426 ms
ISI CV 57.9886
ISI Median 19.6200 ms
ISI Burst Mean Change 12.2507 %
Spike Rate (Strong Stimulation) 88.5000 Hz
AP 1 Delay Mean (Strong Stimulation) 2.0300 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 11.5800 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 10.4050 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2116.2200 ms
Frequency Filter Type Low-Pass
Frequency Filter Pass Below 45.0335 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 4247.99 µm2
Number of Stems 5.0
Number of Bifurcations 25.0
Number of Branches 54.0
Overall Width 310.216 µm
Overall Height 513.927 µm
Overall Depth 139.68 µm
Average Diameter 0.692476 µm
Total Length 2911.16 µm
Total Surface 6112.42 µm2
Total Volume 2335.41 µm3
Max Euclidean Distance 366.868 µm
Max Path Distance 644.213 µm
Max Branch Order 9.0
Average Contraction 0.956626
Total Fragmentation 2430.0
Partition Asymmetry 0.624322
Average Rall's Ratio 0.914783
Average Bifurcation Angle Local 26.4897 °
Average Bifurcation Angle Remote 60.3407 °
Fractal Dimension 1.00741
Complexity Summary
State Equations 1952
Optimal Time-Step 0.00543 ms
Relative Complexity 656.31 HH
Model Size
Sections 55
Compartments 149
State Equations 1952
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00543 ms
Optimal Time-Step Error 0.31 %
Optimal Time-Step Benchmark Run Time 656.31 HH
 
Maximum Stable Time-Step 0.03125 ms
Maximum Stable Time-Step Error 1.73 %
Max. Stable Time-Step Benchmark Run Time 1781.32 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 19828 Hz
CVODE Steps Per AP 280
CVODE Benchmark Run Time 530.17 HH
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