Layer 4 Delayed Stuttering Large Basket Cell (5)

Model Type:
Cell
Neurolex IDs: Neocortex basket cell
Neocortex Layer 4
Keywords: delayed stuttering,Layer 4,Fast-spiking, interneuron, GABAergic, inhibitory, neocortex, rat, somatosensory cortex, large, basket
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL001096
dSTUT214_L4_LBC_aecec7aee9_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000106
KdShu2007.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCH000115
StochKv_deterministic.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL001096
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Fast Spikers (FS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -75.88 mV
Rheobase Current Interval (0.15221, 0.15381] nA
Threshold Current Interval (0.35156, 0.41016] nA
Bias Current (to -70.00 mV) 0.0290 nA
Testing Temperature 34.0 °C
Stability Interval [-1.875, 15.0] nA
AP 1-2 Amplitude Drop 5.1789 mV
AP 1 Steady State Amplitude Change 5.1351 mV
AP 1 Amplitude 71.9192 mV
AP 1 Width at Half Height 0.7200 ms
AP 1 Width (Peak To Trough) 3.5100 ms
AP 1 Rate of Change Peak to Trough -25.1117 mV/ms
AP 1 AHP Depth 16.2228 mV
AP2 Amplitude 66.7403 mV
AP2 Width at Half Height 0.7400 ms
AP 2 Width (Peak to Trough) 3.6900 ms
AP 2 Rate of Change Peak to Trough -22.6808 mV/ms
AP 2 AHP Depth 16.9518 mV
AP 1-2 Amplitude Change Percent -7.2009 %
AP 1-2 Half Width Change Percent 2.7778 %
AP 1-2 Rate of Change Peak to Trough Percent Change -9.6803 %
AP 1-2 AHP Depth Percent Change 4.4935 %
Input Resistance 251.1105 MΩ
AP 1 Delay Mean 6.0500 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 23.1300 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 18.0350 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean 4.5455 %
Steady State Accommodation Mean 4.5455 %
Accommodation Rate to Steady State 0.1965 %/ms
Accommodation at Steady State Mean -4.7233 %
Accommodation Rate Mean at Steady State 0.0010 ms
ISI CV 55.2580
ISI Median 17.7700 ms
ISI Burst Mean Change 11.1827 %
Spike Rate (Strong Stimulation) 99.0000 Hz
AP 1 Delay Mean (Strong Stimulation) 2.4000 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 11.3400 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 9.6300 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2079.5400 ms
Frequency Filter Type Low-Pass
Frequency Filter Pass Below 37.7219 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 3649.29 µm2
Number of Stems 6.0
Number of Bifurcations 21.0
Number of Branches 47.0
Overall Width 258.678 µm
Overall Height 383.42 µm
Overall Depth 200.81 µm
Average Diameter 0.833178 µm
Total Length 3093.16 µm
Total Surface 6700.39 µm2
Total Volume 2194.02 µm3
Max Euclidean Distance 286.523 µm
Max Path Distance 297.107 µm
Max Branch Order 4.0
Average Contraction 0.967937
Total Fragmentation 989.0
Partition Asymmetry 0.47619
Average Rall's Ratio 1.49917
Average Bifurcation Angle Local 45.0102 °
Average Bifurcation Angle Remote 49.9942 °
Fractal Dimension 1.00708
Complexity Summary
State Equations 2056
Optimal Time-Step 0.00774 ms
Relative Complexity 459.01 HH
Model Size
Sections 47
Compartments 157
State Equations 2056
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00774 ms
Optimal Time-Step Error 0.48 %
Optimal Time-Step Benchmark Run Time 459.01 HH
 
Maximum Stable Time-Step 0.0625 ms
Maximum Stable Time-Step Error 2.85 %
Max. Stable Time-Step Benchmark Run Time 888.20 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 15578 Hz
CVODE Steps Per AP 249
CVODE Benchmark Run Time 422.19 HH
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