Layer 4 Delayed Stuttering Large Basket Cell (1)

Model Type:
Cell
Neurolex IDs: Neocortex basket cell
Neocortex Layer 4
Keywords: delayed stuttering,Layer 4,Fast-spiking, interneuron, GABAergic, inhibitory, neocortex, rat, somatosensory cortex, large, basket
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL001092
dSTUT214_L4_LBC_057a5b90cc_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000106
KdShu2007.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCH000115
StochKv_deterministic.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL001092
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Fast Spikers (FS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -75.64 mV
Rheobase Current Interval (0.19707, 0.19867] nA
Threshold Current Interval (0.35156, 0.41016] nA
Bias Current (to -70.00 mV) 0.0385 nA
Testing Temperature 34.0 °C
Stability Interval [-1.875, 15.0] nA
AP 1-2 Amplitude Drop 4.8751 mV
AP 1 Steady State Amplitude Change 4.7500 mV
AP 1 Amplitude 78.4755 mV
AP 1 Width at Half Height 0.5800 ms
AP 1 Width (Peak To Trough) 2.3700 ms
AP 1 Rate of Change Peak to Trough -39.9741 mV/ms
AP 1 AHP Depth 16.2631 mV
AP2 Amplitude 73.6004 mV
AP2 Width at Half Height 0.6000 ms
AP 2 Width (Peak to Trough) 2.4700 ms
AP 2 Rate of Change Peak to Trough -36.3488 mV/ms
AP 2 AHP Depth 16.1811 mV
AP 1-2 Amplitude Change Percent -6.2123 %
AP 1-2 Half Width Change Percent 3.4483 %
AP 1-2 Rate of Change Peak to Trough Percent Change -9.0692 %
AP 1-2 AHP Depth Percent Change -0.5041 %
Input Resistance 180.1991 MΩ
AP 1 Delay Mean 5.1600 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 21.7600 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 17.8150 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean 4.5455 %
Steady State Accommodation Mean 4.5455 %
Accommodation Rate to Steady State 0.1114 %/ms
Accommodation at Steady State Mean -6.6821 %
Accommodation Rate Mean at Steady State 0.2902 ms
ISI CV 45.4590
ISI Median 17.5900 ms
ISI Burst Mean Change 14.6386 %
Spike Rate (Strong Stimulation) 103.0000 Hz
AP 1 Delay Mean (Strong Stimulation) 1.6900 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 10.0500 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 9.1500 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2084.9700 ms
Frequency Filter Type Band-Pass
Frequency Filter Pass Above 29.0000 Hz
Frequency Filter Pass Below 91.1792 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 5995.35 µm2
Number of Stems 6.0
Number of Bifurcations 29.0
Number of Branches 63.0
Overall Width 276.889 µm
Overall Height 587.949 µm
Overall Depth 125.89 µm
Average Diameter 0.784478 µm
Total Length 4426.47 µm
Total Surface 9728.34 µm2
Total Volume 3342.78 µm3
Max Euclidean Distance 376.373 µm
Max Path Distance 413.239 µm
Max Branch Order 5.0
Average Contraction 0.973843
Total Fragmentation 1107.0
Partition Asymmetry 0.424817
Average Rall's Ratio 0.831667
Average Bifurcation Angle Local 37.8784 °
Average Bifurcation Angle Remote 42.8499 °
Fractal Dimension 1.00459
Complexity Summary
State Equations 2875
Optimal Time-Step 0.00788 ms
Relative Complexity 631.60 HH
Model Size
Sections 64
Compartments 220
State Equations 2875
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00788 ms
Optimal Time-Step Error 0.44 %
Optimal Time-Step Benchmark Run Time 631.60 HH
 
Maximum Stable Time-Step 0.0625 ms
Maximum Stable Time-Step Error 3.07 %
Max. Stable Time-Step Benchmark Run Time 1244.57 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 16975 Hz
CVODE Steps Per AP 248
CVODE Benchmark Run Time 637.12 HH
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