Layer 4 Delayed Stuttering Bipolar Cell (5)

Model Type:
Cell
Neurolex IDs: Bipolar Cell
Neocortex Layer 4
Keywords: delayed stuttering,Layer 4,GABAergic, inhibitory, neocortex, rat, somatosensory cortex, bipolar
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL001091
dSTUT214_L4_BP_b88746aff4_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000106
KdShu2007.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCH000115
StochKv_deterministic.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL001091
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Fast Spikers (FS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -73.64 mV
Rheobase Current Interval (0.03254, 0.03290] nA
Threshold Current Interval (0.04578, 0.09155] nA
Bias Current (to -80.00 mV) -0.0096 nA
Testing Temperature 34.0 °C
Stability Interval [0.0, 11.71875] nA
AP 1-2 Amplitude Drop 4.0250 mV
AP 1 Steady State Amplitude Change 3.7270 mV
AP 1 Amplitude 91.1925 mV
AP 1 Width at Half Height 0.4700 ms
AP 1 Width (Peak To Trough) 1.8100 ms
AP 1 Rate of Change Peak to Trough -63.3915 mV/ms
AP 1 AHP Depth 23.5461 mV
AP2 Amplitude 87.1675 mV
AP2 Width at Half Height 0.4600 ms
AP 2 Width (Peak to Trough) 1.7900 ms
AP 2 Rate of Change Peak to Trough -61.8371 mV/ms
AP 2 AHP Depth 23.5210 mV
AP 1-2 Amplitude Change Percent -4.4137 %
AP 1-2 Half Width Change Percent -2.1277 %
AP 1-2 Rate of Change Peak to Trough Percent Change -2.4520 %
AP 1-2 AHP Depth Percent Change -0.1069 %
Input Resistance 738.2804 MΩ
AP 1 Delay Mean 3.4800 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 25.5900 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 22.7550 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -11.7647 %
Steady State Accommodation Mean -17.6471 %
Accommodation Rate to Steady State -0.0183 %/ms
Accommodation at Steady State Mean -24.0010 %
Accommodation Rate Mean at Steady State 1274.9373 ms
ISI CV 15.7787
ISI Median 26.4550 ms
ISI Burst Mean Change 5.8345 %
Spike Rate (Strong Stimulation) 68.0000 Hz
AP 1 Delay Mean (Strong Stimulation) 1.4800 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 12.6700 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 12.3050 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2128.5100 ms
Frequency Filter Type Low-Pass
Frequency Filter Pass Below 45.0335 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 2094.2 µm2
Number of Stems 2.0
Number of Bifurcations 7.0
Number of Branches 15.0
Overall Width 64.6947 µm
Overall Height 813.723 µm
Overall Depth 39.99 µm
Average Diameter 1.07428 µm
Total Length 1186.19 µm
Total Surface 2421.52 µm2
Total Volume 869.922 µm3
Max Euclidean Distance 844.48 µm
Max Path Distance 861.986 µm
Max Branch Order 6.0
Average Contraction 0.990599
Total Fragmentation 256.0
Partition Asymmetry 0.857143
Average Rall's Ratio 1.51667
Average Bifurcation Angle Local 51.0201 °
Average Bifurcation Angle Remote 46.9325 °
Fractal Dimension 1.00189
Complexity Summary
State Equations 821
Optimal Time-Step 0.00543 ms
Relative Complexity 248.45 HH
Model Size
Sections 16
Compartments 62
State Equations 821
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00543 ms
Optimal Time-Step Error 0.19 %
Optimal Time-Step Benchmark Run Time 248.45 HH
 
Maximum Stable Time-Step 0.03125 ms
Maximum Stable Time-Step Error 0.80 %
Max. Stable Time-Step Benchmark Run Time 673.84 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 19098 Hz
CVODE Steps Per AP 314
CVODE Benchmark Run Time 197.15 HH
Website & Images Copyright NeuroML © 2021 For questions: Contact us Links: Search Test |  ModelDB WS