Layer 4 Delayed Stuttering Bipolar Cell (4)

Model Type:
Cell
Neurolex IDs: Bipolar Cell
Neocortex Layer 4
Keywords: delayed stuttering,Layer 4,GABAergic, inhibitory, neocortex, rat, somatosensory cortex, bipolar, biophysical, delayed stuttering bipolar cell, Realistic Network, Neuron or other electrically excitable cell, Synapse, Spatio-temporal Activity Patterns, Detailed Neuronal Models
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL001090
dSTUT214_L4_BP_af68a93e57_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000106
KdShu2007.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCH000115
StochKv_deterministic.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL001090
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Fast Spikers (FS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -73.65 mV
Rheobase Current Interval (0.03148, 0.03167] nA
Threshold Current Interval (0.00000, 0.04944] nA
Bias Current (to -80.00 mV) -0.0092 nA
Testing Temperature 34.0 °C
Stability Interval [0.0, 12.65625] nA
AP 1-2 Amplitude Drop 2.8609 mV
AP 1 Steady State Amplitude Change 3.1278 mV
AP 1 Amplitude 91.1211 mV
AP 1 Width at Half Height 0.4700 ms
AP 1 Width (Peak To Trough) 1.7200 ms
AP 1 Rate of Change Peak to Trough -67.0748 mV/ms
AP 1 AHP Depth 24.2476 mV
AP2 Amplitude 88.2601 mV
AP2 Width at Half Height 0.4500 ms
AP 2 Width (Peak to Trough) 1.6200 ms
AP 2 Rate of Change Peak to Trough -69.1572 mV/ms
AP 2 AHP Depth 23.7744 mV
AP 1-2 Amplitude Change Percent -3.1397 %
AP 1-2 Half Width Change Percent -4.2553 %
AP 1-2 Rate of Change Peak to Trough Percent Change 3.1045 %
AP 1-2 AHP Depth Percent Change -1.9514 %
Input Resistance 770.0635 MΩ
AP 1 Delay Mean 3.4500 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 25.8400 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 23.0300 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -11.7647 %
Steady State Accommodation Mean -17.6471 %
Accommodation Rate to Steady State -0.0180 %/ms
Accommodation at Steady State Mean -24.3967 %
Accommodation Rate Mean at Steady State 1221.8893 ms
ISI CV 15.2577
ISI Median 26.9500 ms
ISI Burst Mean Change 5.7168 %
Spike Rate (Strong Stimulation) 67.0000 Hz
AP 1 Delay Mean (Strong Stimulation) 1.4600 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 12.7700 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 12.4350 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2127.0300 ms
Frequency Filter Type Low-Pass
Frequency Filter Pass Below 51.9968 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 2094.2 µm2
Number of Stems 2.0
Number of Bifurcations 7.0
Number of Branches 15.0
Overall Width 50.9225 µm
Overall Height 727.643 µm
Overall Depth 39.98 µm
Average Diameter 1.07428 µm
Total Length 1028.43 µm
Total Surface 2159.42 µm2
Total Volume 830.492 µm3
Max Euclidean Distance 744.132 µm
Max Path Distance 759.717 µm
Max Branch Order 6.0
Average Contraction 0.990602
Total Fragmentation 256.0
Partition Asymmetry 0.857143
Average Rall's Ratio 1.51667
Average Bifurcation Angle Local 50.5689 °
Average Bifurcation Angle Remote 46.7138 °
Fractal Dimension 1.00189
Complexity Summary
Relative Complexity 181.55 HH
State Equations 691
Optimal Time-Step 0.00538 ms
Model Size
Sections 16
Compartments 52
State Equations 691
Variable Time-Step Complexity
CVODE Steady State Step Frequency 19071 Hz
CVODE Steps Per AP 302
CVODE Benchmark Run Time 181.55 HH
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