Layer 4 Delayed Stuttering Bipolar Cell (2)

Model Type:
Cell
Neurolex IDs: Bipolar Cell
Neocortex Layer 4
Keywords: delayed stuttering,Layer 4,GABAergic, inhibitory, neocortex, rat, somatosensory cortex, bipolar
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL001088
dSTUT214_L4_BP_a62582b74c_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000106
KdShu2007.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCH000115
StochKv_deterministic.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL001088
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Fast Spikers (FS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -73.52 mV
Rheobase Current Interval (0.03225, 0.03244] nA
Threshold Current Interval (0.00000, 0.04944] nA
Bias Current (to -80.00 mV) -0.0100 nA
Testing Temperature 34.0 °C
Stability Interval [0.0, 12.65625] nA
AP 1-2 Amplitude Drop 3.3248 mV
AP 1 Steady State Amplitude Change 3.7010 mV
AP 1 Amplitude 91.2934 mV
AP 1 Width at Half Height 0.4700 ms
AP 1 Width (Peak To Trough) 1.7700 ms
AP 1 Rate of Change Peak to Trough -65.1905 mV/ms
AP 1 AHP Depth 24.0937 mV
AP2 Amplitude 87.9686 mV
AP2 Width at Half Height 0.4500 ms
AP 2 Width (Peak to Trough) 1.7100 ms
AP 2 Rate of Change Peak to Trough -65.2536 mV/ms
AP 2 AHP Depth 23.6151 mV
AP 1-2 Amplitude Change Percent -3.6419 %
AP 1-2 Half Width Change Percent -4.2553 %
AP 1-2 Rate of Change Peak to Trough Percent Change 0.0969 %
AP 1-2 AHP Depth Percent Change -1.9862 %
Input Resistance 723.7421 MΩ
AP 1 Delay Mean 3.4600 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 25.7200 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 22.9050 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -11.7647 %
Steady State Accommodation Mean -17.6471 %
Accommodation Rate to Steady State -0.0181 %/ms
Accommodation at Steady State Mean -24.4482 %
Accommodation Rate Mean at Steady State 1256.7656 ms
ISI CV 15.3888
ISI Median 26.7300 ms
ISI Burst Mean Change 5.7951 %
Spike Rate (Strong Stimulation) 67.5000 Hz
AP 1 Delay Mean (Strong Stimulation) 1.4800 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 12.6900 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 12.3350 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2135.0900 ms
Frequency Filter Type Low-Pass
Frequency Filter Pass Below 51.9968 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 2094.2 µm2
Number of Stems 2.0
Number of Bifurcations 7.0
Number of Branches 15.0
Overall Width 72.6836 µm
Overall Height 896.043 µm
Overall Depth 53.81 µm
Average Diameter 1.07428 µm
Total Length 1287.12 µm
Total Surface 2647.82 µm2
Total Volume 908.919 µm3
Max Euclidean Distance 936.361 µm
Max Path Distance 951.462 µm
Max Branch Order 6.0
Average Contraction 0.990258
Total Fragmentation 256.0
Partition Asymmetry 0.857143
Average Rall's Ratio 1.51667
Average Bifurcation Angle Local 51.8263 °
Average Bifurcation Angle Remote 47.514 °
Fractal Dimension 1.00204
Complexity Summary
State Equations 847
Optimal Time-Step 0.00543 ms
Relative Complexity 280.99 HH
Model Size
Sections 16
Compartments 64
State Equations 847
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00543 ms
Optimal Time-Step Error 0.25 %
Optimal Time-Step Benchmark Run Time 280.99 HH
 
Maximum Stable Time-Step 0.03125 ms
Maximum Stable Time-Step Error 1.10 %
Max. Stable Time-Step Benchmark Run Time 762.39 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 18935 Hz
CVODE Steps Per AP 295
CVODE Benchmark Run Time 219.45 HH
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