Layer 6 Delayed Non-accommodating Small Basket Cell (1)

Model Type:
Cell
Neurolex IDs: Neocortex basket cell
Neocortex Layer 6
Keywords: delayed non-accommodating,Layer 6,Fast-spiking, interneuron, GABAergic, inhibitory, neocortex, rat, somatosensory cortex, small, basket
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL001077
dNAC222_L6_SBC_1404bc18ce_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000106
KdShu2007.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL001077
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Fast Spikers (FS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -71.59 mV
Rheobase Current Interval (0.06134, 0.06226] nA
Threshold Current Interval (0.17578, 0.23438] nA
Bias Current (to -80.00 mV) -0.0235 nA
Testing Temperature 34.0 °C
Stability Interval [-1.5625, 15.0] nA
AP 1-2 Amplitude Drop 1.4808 mV
AP 1 Steady State Amplitude Change 0.8986 mV
AP 1 Amplitude 71.2721 mV
AP 1 Width at Half Height 0.6400 ms
AP 1 Width (Peak To Trough) 3.1300 ms
AP 1 Rate of Change Peak to Trough -27.1547 mV/ms
AP 1 AHP Depth 13.7221 mV
AP2 Amplitude 69.7912 mV
AP2 Width at Half Height 0.6400 ms
AP 2 Width (Peak to Trough) 3.3100 ms
AP 2 Rate of Change Peak to Trough -25.4918 mV/ms
AP 2 AHP Depth 14.5868 mV
AP 1-2 Amplitude Change Percent -2.0777 %
AP 1-2 Half Width Change Percent -0.0000 %
AP 1-2 Rate of Change Peak to Trough Percent Change -6.1236 %
AP 1-2 AHP Depth Percent Change 6.3012 %
Input Resistance 344.1875 MΩ
AP 1 Delay Mean 13.4200 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 42.3000 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 29.6300 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean 7.1429 %
Steady State Accommodation Mean 0.0000 %
Accommodation Rate to Steady State 0.0000 %/ms
Accommodation at Steady State Mean -0.0000 %
Accommodation Rate Mean at Steady State 131.2224 ms
ISI CV 41.1832
ISI Median 28.2400 ms
ISI Burst Mean Change 5.1939 %
Spike Rate (Strong Stimulation) 67.5000 Hz
AP 1 Delay Mean (Strong Stimulation) 4.3900 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 17.3800 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 14.3250 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2072.2400 ms
Frequency Filter Type Low-Pass
Frequency Filter Pass Below 109.5890 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 3701.37 µm2
Number of Stems 4.0
Number of Bifurcations 28.0
Number of Branches 59.0
Overall Width 250.346 µm
Overall Height 677.917 µm
Overall Depth 118.92 µm
Average Diameter 0.798289 µm
Total Length 3016.85 µm
Total Surface 7596.98 µm2
Total Volume 2875.36 µm3
Max Euclidean Distance 586.728 µm
Max Path Distance 627.628 µm
Max Branch Order 8.0
Average Contraction 0.92945
Total Fragmentation 2968.0
Partition Asymmetry 0.581143
Average Rall's Ratio 0.850625
Average Bifurcation Angle Local 34.9029 °
Average Bifurcation Angle Remote 64.6904 °
Fractal Dimension 1.01447
Complexity Summary
State Equations 1865
Optimal Time-Step 0.00539 ms
Relative Complexity 555.64 HH
Model Size
Sections 60
Compartments 154
State Equations 1865
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00539 ms
Optimal Time-Step Error 0.22 %
Optimal Time-Step Benchmark Run Time 555.64 HH
 
Maximum Stable Time-Step 0.03125 ms
Maximum Stable Time-Step Error 1.24 %
Max. Stable Time-Step Benchmark Run Time 1498.19 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 16163 Hz
CVODE Steps Per AP 338
CVODE Benchmark Run Time 385.20 HH
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