Layer 5 Delayed Non-accommodating Small Basket Cell (5)

Model Type:
Cell
Neurolex IDs: Neocortex basket cell
Neocortex Layer 5
Keywords: delayed non-accommodating,Layer 5,Fast-spiking, interneuron, GABAergic, inhibitory, neocortex, rat, somatosensory cortex, small, basket
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL001071
dNAC222_L5_SBC_e37bc9bae0_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000106
KdShu2007.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL001071
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Fast Spikers (FS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -71.43 mV
Rheobase Current Interval (0.04486, 0.04578] nA
Threshold Current Interval (0.17578, 0.23438] nA
Bias Current (to -80.00 mV) -0.0221 nA
Testing Temperature 34.0 °C
Stability Interval [-0.9375, 15.0] nA
AP 1-2 Amplitude Drop 1.2635 mV
AP 1 Steady State Amplitude Change 1.6593 mV
AP 1 Amplitude 71.2080 mV
AP 1 Width at Half Height 0.6500 ms
AP 1 Width (Peak To Trough) 3.7600 ms
AP 1 Rate of Change Peak to Trough -23.2681 mV/ms
AP 1 AHP Depth 16.2800 mV
AP2 Amplitude 69.9445 mV
AP2 Width at Half Height 0.6800 ms
AP 2 Width (Peak to Trough) 3.8300 ms
AP 2 Rate of Change Peak to Trough -22.3893 mV/ms
AP 2 AHP Depth 15.8065 mV
AP 1-2 Amplitude Change Percent -1.7744 %
AP 1-2 Half Width Change Percent 4.6154 %
AP 1-2 Rate of Change Peak to Trough Percent Change -3.7768 %
AP 1-2 AHP Depth Percent Change -2.9086 %
Input Resistance 389.2405 MΩ
AP 1 Delay Mean 14.0100 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 47.2000 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 33.6850 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean 0.0000 %
Steady State Accommodation Mean -8.3333 %
Accommodation Rate to Steady State -0.0291 %/ms
Accommodation at Steady State Mean -9.1099 %
Accommodation Rate Mean at Steady State 1505.1444 ms
ISI CV 48.6317
ISI Median 35.3850 ms
ISI Burst Mean Change 2.9828 %
Spike Rate (Strong Stimulation) 52.0000 Hz
AP 1 Delay Mean (Strong Stimulation) 5.0500 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 22.0500 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 17.9450 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2104.6200 ms
Frequency Filter Type Constant
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 6826.28 µm2
Number of Stems 4.0
Number of Bifurcations 20.0
Number of Branches 43.0
Overall Width 324.387 µm
Overall Height 478.754 µm
Overall Depth 36.84 µm
Average Diameter 0.90539 µm
Total Length 2350.31 µm
Total Surface 5963.44 µm2
Total Volume 3685.73 µm3
Max Euclidean Distance 341.559 µm
Max Path Distance 376.483 µm
Max Branch Order 7.0
Average Contraction 0.963181
Total Fragmentation 1102.0
Partition Asymmetry 0.446032
Average Rall's Ratio 0.521765
Average Bifurcation Angle Local 41.6278 °
Average Bifurcation Angle Remote 52.7087 °
Fractal Dimension 1.00885
Complexity Summary
State Equations 1481
Optimal Time-Step 0.00539 ms
Relative Complexity 460.25 HH
Model Size
Sections 44
Compartments 122
State Equations 1481
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00539 ms
Optimal Time-Step Error 0.17 %
Optimal Time-Step Benchmark Run Time 460.25 HH
 
Maximum Stable Time-Step 0.03125 ms
Maximum Stable Time-Step Error 0.84 %
Max. Stable Time-Step Benchmark Run Time 1240.94 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 16052 Hz
CVODE Steps Per AP 422
CVODE Benchmark Run Time 330.89 HH
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