Layer 5 Delayed Non-accommodating Large Basket Cell (5)

Model Type:
Cell
Neurolex IDs: Neocortex basket cell
Neocortex Layer 5
Keywords: delayed non-accommodating,Layer 5,Fast-spiking, interneuron, GABAergic, inhibitory, neocortex, rat, somatosensory cortex, large, basket
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL001061
dNAC222_L5_LBC_f906bb679c_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000106
KdShu2007.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL001061
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Fast Spikers (FS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -71.60 mV
Rheobase Current Interval (0.07233, 0.07324] nA
Threshold Current Interval (0.17578, 0.23438] nA
Bias Current (to -80.00 mV) -0.0234 nA
Testing Temperature 34.0 °C
Stability Interval [-1.25, 15.0] nA
AP 1-2 Amplitude Drop 2.6423 mV
AP 1 Steady State Amplitude Change 2.7265 mV
AP 1 Amplitude 80.0545 mV
AP 1 Width at Half Height 0.5200 ms
AP 1 Width (Peak To Trough) 2.7400 ms
AP 1 Rate of Change Peak to Trough -37.1817 mV/ms
AP 1 AHP Depth 21.8234 mV
AP2 Amplitude 77.4122 mV
AP2 Width at Half Height 0.5200 ms
AP 2 Width (Peak to Trough) 2.7900 ms
AP 2 Rate of Change Peak to Trough -35.8971 mV/ms
AP 2 AHP Depth 22.7407 mV
AP 1-2 Amplitude Change Percent -3.3006 %
AP 1-2 Half Width Change Percent -0.0000 %
AP 1-2 Rate of Change Peak to Trough Percent Change -3.4549 %
AP 1-2 AHP Depth Percent Change 4.2035 %
Input Resistance 366.8706 MΩ
AP 1 Delay Mean 9.0000 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 37.3300 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 28.8700 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -7.1429 %
Steady State Accommodation Mean -7.1429 %
Accommodation Rate to Steady State -0.0098 %/ms
Accommodation at Steady State Mean -14.0717 %
Accommodation Rate Mean at Steady State 1312.3619 ms
ISI CV 28.9069
ISI Median 31.3650 ms
ISI Burst Mean Change 3.8122 %
Spike Rate (Strong Stimulation) 57.5000 Hz
AP 1 Delay Mean (Strong Stimulation) 3.2500 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 17.7300 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 15.5450 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2068.6900 ms
Frequency Filter Type Low-Pass
Frequency Filter Pass Below 80.9288 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 11579.5 µm2
Number of Stems 8.0
Number of Bifurcations 48.0
Number of Branches 103.0
Overall Width 252.675 µm
Overall Height 321.715 µm
Overall Depth 306.13 µm
Average Diameter 0.661825 µm
Total Length 4387.26 µm
Total Surface 5800.79 µm2
Total Volume 4107.29 µm3
Max Euclidean Distance 251.049 µm
Max Path Distance 313.698 µm
Max Branch Order 10.0
Average Contraction 0.975133
Total Fragmentation 2271.0
Partition Asymmetry 0.455871
Average Rall's Ratio 0.5002
Average Bifurcation Angle Local 22.6027 °
Average Bifurcation Angle Remote 44.2036 °
Fractal Dimension 1.00513
Complexity Summary
State Equations 2681
Optimal Time-Step 0.00542 ms
Relative Complexity 859.63 HH
Model Size
Sections 104
Compartments 222
State Equations 2681
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00542 ms
Optimal Time-Step Error 0.33 %
Optimal Time-Step Benchmark Run Time 859.63 HH
 
Maximum Stable Time-Step 0.03125 ms
Maximum Stable Time-Step Error 1.34 %
Max. Stable Time-Step Benchmark Run Time 2327.82 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 17328 Hz
CVODE Steps Per AP 368
CVODE Benchmark Run Time 643.40 HH
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