Layer 5 Delayed Non-accommodating Large Basket Cell (3)

Model Type:
Cell
Neurolex IDs: Neocortex basket cell
Neocortex Layer 5
Keywords: delayed non-accommodating,Layer 5,Fast-spiking, interneuron, GABAergic, inhibitory, neocortex, rat, somatosensory cortex, large, basket
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL001059
dNAC222_L5_LBC_93c04dc3d5_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000106
KdShu2007.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL001059
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Fast Spikers (FS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -71.41 mV
Rheobase Current Interval (0.04669, 0.04738] nA
Threshold Current Interval (0.11719, 0.17578] nA
Bias Current (to -80.00 mV) -0.0183 nA
Testing Temperature 34.0 °C
Stability Interval [-1.25, 15.0] nA
AP 1-2 Amplitude Drop 1.1136 mV
AP 1 Steady State Amplitude Change 1.2615 mV
AP 1 Amplitude 75.9099 mV
AP 1 Width at Half Height 0.6000 ms
AP 1 Width (Peak To Trough) 3.1600 ms
AP 1 Rate of Change Peak to Trough -30.0012 mV/ms
AP 1 AHP Depth 18.8940 mV
AP2 Amplitude 74.7963 mV
AP2 Width at Half Height 0.5900 ms
AP 2 Width (Peak to Trough) 3.2000 ms
AP 2 Rate of Change Peak to Trough -29.3857 mV/ms
AP 2 AHP Depth 19.2380 mV
AP 1-2 Amplitude Change Percent -1.4670 %
AP 1-2 Half Width Change Percent -1.6667 %
AP 1-2 Rate of Change Peak to Trough Percent Change -2.0516 %
AP 1-2 AHP Depth Percent Change 1.8207 %
Input Resistance 471.1119 MΩ
AP 1 Delay Mean 11.0300 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 40.2900 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 29.8200 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean 0.0000 %
Steady State Accommodation Mean -7.6923 %
Accommodation Rate to Steady State -0.1088 %/ms
Accommodation at Steady State Mean -8.9192 %
Accommodation Rate Mean at Steady State 1784.6578 ms
ISI CV 53.5567
ISI Median 31.2100 ms
ISI Burst Mean Change 3.8278 %
Spike Rate (Strong Stimulation) 59.0000 Hz
AP 1 Delay Mean (Strong Stimulation) 3.8800 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 18.5200 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 15.6750 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2075.9000 ms
Frequency Filter Type Low-Pass
Frequency Filter Pass Below 118.0056 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 4247.99 µm2
Number of Stems 5.0
Number of Bifurcations 25.0
Number of Branches 54.0
Overall Width 303.454 µm
Overall Height 552.762 µm
Overall Depth 141.38 µm
Average Diameter 0.692476 µm
Total Length 3032.26 µm
Total Surface 6299.58 µm2
Total Volume 2365.73 µm3
Max Euclidean Distance 398.301 µm
Max Path Distance 685.72 µm
Max Branch Order 9.0
Average Contraction 0.956725
Total Fragmentation 2430.0
Partition Asymmetry 0.624322
Average Rall's Ratio 0.914783
Average Bifurcation Angle Local 21.919 °
Average Bifurcation Angle Remote 60.3666 °
Fractal Dimension 1.00729
Complexity Summary
State Equations 1925
Optimal Time-Step 0.00541 ms
Relative Complexity 601.12 HH
Model Size
Sections 55
Compartments 159
State Equations 1925
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00541 ms
Optimal Time-Step Error 0.18 %
Optimal Time-Step Benchmark Run Time 601.12 HH
 
Maximum Stable Time-Step 0.03125 ms
Maximum Stable Time-Step Error 0.94 %
Max. Stable Time-Step Benchmark Run Time 1626.80 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 17872 Hz
CVODE Steps Per AP 324
CVODE Benchmark Run Time 451.73 HH
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