Layer 5 Delayed Non-accommodating Large Basket Cell (2)

Model Type:
Cell
Neurolex IDs: Neocortex basket cell
Neocortex Layer 5
Keywords: delayed non-accommodating,Layer 5,Fast-spiking, interneuron, GABAergic, inhibitory, neocortex, rat, somatosensory cortex, large, basket, biophysical, delayed non-accommodating large basket cell, Realistic Network, Neuron or other electrically excitable cell, Synapse, Spatio-temporal Activity Patterns, Detailed Neuronal Models
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL001058
dNAC222_L5_LBC_58bb1b2407_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000106
KdShu2007.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL001058
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Fast Spikers (FS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -71.64 mV
Rheobase Current Interval (0.07324, 0.07439] nA
Threshold Current Interval (0.23438, 0.29297] nA
Bias Current (to -80.00 mV) -0.0253 nA
Testing Temperature 34.0 °C
Stability Interval [-1.875, 15.0] nA
AP 1-2 Amplitude Drop 1.5286 mV
AP 1 Steady State Amplitude Change 1.0632 mV
AP 1 Amplitude 71.1363 mV
AP 1 Width at Half Height 0.6400 ms
AP 1 Width (Peak To Trough) 3.7600 ms
AP 1 Rate of Change Peak to Trough -23.3584 mV/ms
AP 1 AHP Depth 16.6914 mV
AP2 Amplitude 69.6077 mV
AP2 Width at Half Height 0.6400 ms
AP 2 Width (Peak to Trough) 3.9400 ms
AP 2 Rate of Change Peak to Trough -22.0136 mV/ms
AP 2 AHP Depth 17.1261 mV
AP 1-2 Amplitude Change Percent -2.1488 %
AP 1-2 Half Width Change Percent 0.0000 %
AP 1-2 Rate of Change Peak to Trough Percent Change -5.7571 %
AP 1-2 AHP Depth Percent Change 2.6045 %
Input Resistance 316.9998 MΩ
AP 1 Delay Mean 14.2500 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 46.5800 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 32.8250 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean 8.3333 %
Steady State Accommodation Mean 0.0000 %
Accommodation Rate to Steady State 0.0000 %/ms
Accommodation at Steady State Mean -0.0000 %
Accommodation Rate Mean at Steady State 146.8721 ms
ISI CV 51.4537
ISI Median 31.3200 ms
ISI Burst Mean Change 3.0622 %
Spike Rate (Strong Stimulation) 61.0000 Hz
AP 1 Delay Mean (Strong Stimulation) 4.5900 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 19.2800 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 15.7850 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2091.3700 ms
Frequency Filter Type Low-Pass
Frequency Filter Pass Below 132.7520 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 6212.91 µm2
Number of Stems 7.0
Number of Bifurcations 13.0
Number of Branches 32.0
Overall Width 430.263 µm
Overall Height 556.543 µm
Overall Depth 147.89 µm
Average Diameter 1.04116 µm
Total Length 3082.3 µm
Total Surface 7898.12 µm2
Total Volume 3152.5 µm3
Max Euclidean Distance 433.894 µm
Max Path Distance 479.806 µm
Max Branch Order 3.0
Average Contraction 0.971723
Total Fragmentation 626.0
Partition Asymmetry 0.384615
Average Rall's Ratio 0.766667
Average Bifurcation Angle Local 50.685 °
Average Bifurcation Angle Remote 48.8627 °
Fractal Dimension 1.0044
Complexity Summary
Relative Complexity 379.76 HH
State Equations 1877
Optimal Time-Step 0.00770 ms
Model Size
Sections 33
Compartments 155
State Equations 1877
Variable Time-Step Complexity
CVODE Steady State Step Frequency 15110 Hz
CVODE Steps Per AP 297
CVODE Benchmark Run Time 379.76 HH
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