Layer 5 Delayed Non-accommodating Large Basket Cell (1)

Model Type:
Cell
Neurolex IDs: Neocortex basket cell
Neocortex Layer 5
Keywords: delayed non-accommodating,Layer 5,Fast-spiking, interneuron, GABAergic, inhibitory, neocortex, rat, somatosensory cortex, large, basket
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL001057
dNAC222_L5_LBC_0ffcc91920_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000106
KdShu2007.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL001057
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Fast Spikers (FS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -71.46 mV
Rheobase Current Interval (0.10025, 0.10162] nA
Threshold Current Interval (0.29297, 0.35156] nA
Bias Current (to -80.00 mV) -0.0346 nA
Testing Temperature 34.0 °C
Stability Interval [-1.875, 15.0] nA
AP 1-2 Amplitude Drop 2.9297 mV
AP 1 Steady State Amplitude Change 2.7783 mV
AP 1 Amplitude 73.5459 mV
AP 1 Width at Half Height 0.6000 ms
AP 1 Width (Peak To Trough) 2.8300 ms
AP 1 Rate of Change Peak to Trough -33.7935 mV/ms
AP 1 AHP Depth 22.0897 mV
AP2 Amplitude 70.6162 mV
AP2 Width at Half Height 0.6000 ms
AP 2 Width (Peak to Trough) 2.8500 ms
AP 2 Rate of Change Peak to Trough -32.7823 mV/ms
AP 2 AHP Depth 22.8134 mV
AP 1-2 Amplitude Change Percent -3.9835 %
AP 1-2 Half Width Change Percent 0.0000 %
AP 1-2 Rate of Change Peak to Trough Percent Change -2.9922 %
AP 1-2 AHP Depth Percent Change 3.2763 %
Input Resistance 249.5476 MΩ
AP 1 Delay Mean 10.1400 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 40.1900 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 30.5950 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -7.6923 %
Steady State Accommodation Mean -7.6923 %
Accommodation Rate to Steady State -0.0161 %/ms
Accommodation at Steady State Mean -10.3838 %
Accommodation Rate Mean at Steady State 1616.8349 ms
ISI CV 43.6273
ISI Median 32.2700 ms
ISI Burst Mean Change 3.6273 %
Spike Rate (Strong Stimulation) 58.0000 Hz
AP 1 Delay Mean (Strong Stimulation) 3.4700 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 17.8300 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 15.4450 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2079.1700 ms
Frequency Filter Type Low-Pass
Frequency Filter Pass Below 119.6135 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 15421.5 µm2
Number of Stems 9.0
Number of Bifurcations 36.0
Number of Branches 80.0
Overall Width 413.2 µm
Overall Height 563.057 µm
Overall Depth 458.38 µm
Average Diameter 0.579643 µm
Total Length 7971.66 µm
Total Surface 10059.4 µm2
Total Volume 5767.84 µm3
Max Euclidean Distance 437.26 µm
Max Path Distance 581.287 µm
Max Branch Order 6.0
Average Contraction 0.959085
Total Fragmentation 2219.0
Partition Asymmetry 0.496693
Average Rall's Ratio 1.06525
Average Bifurcation Angle Local 25.3631 °
Average Bifurcation Angle Remote 51.4775 °
Fractal Dimension 1.00775
Complexity Summary
State Equations 4781
Optimal Time-Step 0.00780 ms
Relative Complexity 1099.50 HH
Model Size
Sections 81
Compartments 397
State Equations 4781
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00780 ms
Optimal Time-Step Error 0.26 %
Optimal Time-Step Benchmark Run Time 1099.50 HH
 
Maximum Stable Time-Step 0.0625 ms
Maximum Stable Time-Step Error 2.05 %
Max. Stable Time-Step Benchmark Run Time 2142.84 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 17794 Hz
CVODE Steps Per AP 253
CVODE Benchmark Run Time 1145.99 HH
Website & Images Copyright NeuroML © 2020 For questions: Contact us Links: Search Test |  ModelDB WS