Layer 5 Delayed Non-accommodating Chandelier Cell (2)

Model Type:
Cell
Neurolex IDs: Neocortex Layer 5
Chandelier Cell
Keywords: delayed non-accommodating,Layer 5,GABAergic, inhibitory, neocortex, rat, somatosensory cortex, chandelier, biophysical, delayed non-accommodating chandelier cell, Realistic Network, Neuron or other electrically excitable cell, Synapse, Spatio-temporal Activity Patterns, Detailed Neuronal Models
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL001053
dNAC222_L5_ChC_13b6218d56_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000106
KdShu2007.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL001053
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Fast Spikers (FS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -71.93 mV
Rheobase Current Interval (0.08102, 0.08240] nA
Threshold Current Interval (0.29297, 0.35156] nA
Bias Current (to -80.00 mV) -0.0249 nA
Testing Temperature 34.0 °C
Stability Interval [-2.1875, 15.0] nA
AP 1-2 Amplitude Drop 1.2298 mV
AP 1 Steady State Amplitude Change 0.9296 mV
AP 1 Amplitude 66.8800 mV
AP 1 Width at Half Height 0.7100 ms
AP 1 Width (Peak To Trough) 4.0600 ms
AP 1 Rate of Change Peak to Trough -20.4876 mV/ms
AP 1 AHP Depth 16.2996 mV
AP2 Amplitude 65.6502 mV
AP2 Width at Half Height 0.7200 ms
AP 2 Width (Peak to Trough) 4.2500 ms
AP 2 Rate of Change Peak to Trough -19.3798 mV/ms
AP 2 AHP Depth 16.7139 mV
AP 1-2 Amplitude Change Percent -1.8389 %
AP 1-2 Half Width Change Percent 1.4085 %
AP 1-2 Rate of Change Peak to Trough Percent Change -5.4072 %
AP 1-2 AHP Depth Percent Change 2.5415 %
Input Resistance 303.5597 MΩ
AP 1 Delay Mean 13.6700 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 43.6900 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 30.6350 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean 0.0000 %
Steady State Accommodation Mean 7.6923 %
Accommodation Rate to Steady State 0.1761 %/ms
Accommodation at Steady State Mean -0.0000 %
Accommodation Rate Mean at Steady State 130.2344 ms
ISI CV 48.0088
ISI Median 29.2300 ms
ISI Burst Mean Change 4.0973 %
Spike Rate (Strong Stimulation) 64.0000 Hz
AP 1 Delay Mean (Strong Stimulation) 4.7600 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 18.6600 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 15.0550 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2077.8400 ms
Frequency Filter Type Low-Pass
Frequency Filter Pass Below 134.3736 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 5852.68 µm2
Number of Stems 9.0
Number of Bifurcations 42.0
Number of Branches 92.0
Overall Width 313.006 µm
Overall Height 343.382 µm
Overall Depth 278.74 µm
Average Diameter 0.816308 µm
Total Length 3858.21 µm
Total Surface 8698.88 µm2
Total Volume 3520.47 µm3
Max Euclidean Distance 341.666 µm
Max Path Distance 415.494 µm
Max Branch Order 6.0
Average Contraction 0.95054
Total Fragmentation 2523.0
Partition Asymmetry 0.492435
Average Rall's Ratio 0.857407
Average Bifurcation Angle Local 35.4374 °
Average Bifurcation Angle Remote 59.0623 °
Fractal Dimension 1.01096
Complexity Summary
Relative Complexity 552.23 HH
State Equations 2513
Optimal Time-Step 0.00776 ms
Model Size
Sections 92
Compartments 208
State Equations 2513
Variable Time-Step Complexity
CVODE Steady State Step Frequency 15043 Hz
CVODE Steps Per AP 385
CVODE Benchmark Run Time 552.23 HH
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