Layer 4 Delayed Non-accommodating Large Basket Cell (5)

Model Type:
Cell
Neurolex IDs: Neocortex basket cell
Neocortex Layer 4
Keywords: delayed non-accommodating,Layer 4,Fast-spiking, interneuron, GABAergic, inhibitory, neocortex, rat, somatosensory cortex, large, basket
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL001036
dNAC222_L4_LBC_f6a71a338d_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000106
KdShu2007.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL001036
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Fast Spikers (FS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -71.49 mV
Rheobase Current Interval (0.05081, 0.05150] nA
Threshold Current Interval (0.11719, 0.17578] nA
Bias Current (to -80.00 mV) -0.0167 nA
Testing Temperature 34.0 °C
Stability Interval [-1.25, 15.0] nA
AP 1-2 Amplitude Drop 1.9582 mV
AP 1 Steady State Amplitude Change 2.3019 mV
AP 1 Amplitude 79.4265 mV
AP 1 Width at Half Height 0.5800 ms
AP 1 Width (Peak To Trough) 2.9700 ms
AP 1 Rate of Change Peak to Trough -33.9161 mV/ms
AP 1 AHP Depth 21.3043 mV
AP2 Amplitude 77.4683 mV
AP2 Width at Half Height 0.5700 ms
AP 2 Width (Peak to Trough) 3.0000 ms
AP 2 Rate of Change Peak to Trough -33.1130 mV/ms
AP 2 AHP Depth 21.8706 mV
AP 1-2 Amplitude Change Percent -2.4654 %
AP 1-2 Half Width Change Percent -1.7241 %
AP 1-2 Rate of Change Peak to Trough Percent Change -2.3680 %
AP 1-2 AHP Depth Percent Change 2.6580 %
Input Resistance 522.1626 MΩ
AP 1 Delay Mean 10.1600 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 40.0500 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 30.3600 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -7.6923 %
Steady State Accommodation Mean -7.6923 %
Accommodation Rate to Steady State -0.0100 %/ms
Accommodation at Steady State Mean -15.6009 %
Accommodation Rate Mean at Steady State 1139.8866 ms
ISI CV 24.6940
ISI Median 33.4450 ms
ISI Burst Mean Change 3.1449 %
Spike Rate (Strong Stimulation) 54.5000 Hz
AP 1 Delay Mean (Strong Stimulation) 3.7200 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 19.1300 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 16.3750 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2073.1400 ms
Frequency Filter Type Low-Pass
Frequency Filter Pass Below 78.7154 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 6342.5 µm2
Number of Stems 7.0
Number of Bifurcations 10.0
Number of Branches 26.0
Overall Width 276.636 µm
Overall Height 238.935 µm
Overall Depth 74.43 µm
Average Diameter 0.980132 µm
Total Length 1492.16 µm
Total Surface 4127.97 µm2
Total Volume 2726.06 µm3
Max Euclidean Distance 208.421 µm
Max Path Distance 239.543 µm
Max Branch Order 3.0
Average Contraction 0.944756
Total Fragmentation 1451.0
Partition Asymmetry 0.6
Average Rall's Ratio 1.04
Average Bifurcation Angle Local 1.0306e-06 °
Average Bifurcation Angle Remote 40.3459 °
Fractal Dimension 1.01179
Complexity Summary
State Equations 893
Optimal Time-Step 0.00537 ms
Relative Complexity 280.92 HH
Model Size
Sections 27
Compartments 73
State Equations 893
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00537 ms
Optimal Time-Step Error 0.16 %
Optimal Time-Step Benchmark Run Time 280.92 HH
 
Maximum Stable Time-Step 0.03125 ms
Maximum Stable Time-Step Error 0.93 %
Max. Stable Time-Step Benchmark Run Time 754.57 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 14565 Hz
CVODE Steps Per AP 379
CVODE Benchmark Run Time 182.18 HH
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