Layer 4 Delayed Non-accommodating Bitufted Cell (2)

Model Type:
Cell
Neurolex IDs: Neocortex Layer 4
Keywords: delayed non-accommodating,Layer 4,Rat, somatosensory cortex, bitufted, biophysical, delayed non-accommodating bitufted cell, Realistic Network, Neuron or other electrically excitable cell, Synapse, Spatio-temporal Activity Patterns, Detailed Neuronal Models
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL001023
dNAC222_L4_BTC_5612242ada_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000106
KdShu2007.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL001023
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Fast Spikers (FS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -71.91 mV
Rheobase Current Interval (0.08011, 0.08125] nA
Threshold Current Interval (0.23438, 0.29297] nA
Bias Current (to -80.00 mV) -0.0211 nA
Testing Temperature 34.0 °C
Stability Interval [-1.5625, 15.0] nA
AP 1-2 Amplitude Drop 19.8115 mV
AP 1 Steady State Amplitude Change 9.2510 mV
AP 1 Amplitude 67.4756 mV
AP 1 Width at Half Height 0.7000 ms
AP 1 Width (Peak To Trough) 3.3000 ms
AP 1 Rate of Change Peak to Trough -23.9148 mV/ms
AP 1 AHP Depth 11.4431 mV
AP2 Amplitude 47.6641 mV
AP2 Width at Half Height 1.3700 ms
AP 2 Width (Peak to Trough) 4.4200 ms
AP 2 Rate of Change Peak to Trough -12.8013 mV/ms
AP 2 AHP Depth 8.9176 mV
AP 1-2 Amplitude Change Percent -29.3610 %
AP 1-2 Half Width Change Percent 95.7143 %
AP 1-2 Rate of Change Peak to Trough Percent Change -46.4712 %
AP 1-2 AHP Depth Percent Change -22.0697 %
Input Resistance 355.0316 MΩ
AP 1 Delay Mean 8.3900 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 28.9100 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 26.7450 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean 17.6471 %
Steady State Accommodation Mean 17.6471 %
Accommodation Rate to Steady State 0.6104 %/ms
Accommodation at Steady State Mean -0.0000 %
Accommodation Rate Mean at Steady State 1081.7251 ms
ISI CV 9.1583
ISI Median 20.3700 ms
ISI Burst Mean Change 60.6725 %
Spike Rate (Strong Stimulation) 82.5000 Hz
AP 1 Delay Mean (Strong Stimulation) 3.0800 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 14.0100 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 12.0350 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2119.6800 ms
Frequency Filter Type Constant
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 4955.95 µm2
Number of Stems 6.0
Number of Bifurcations 19.0
Number of Branches 43.0
Overall Width 320.521 µm
Overall Height 388.717 µm
Overall Depth 190.07 µm
Average Diameter 0.841259 µm
Total Length 3151.76 µm
Total Surface 6331.65 µm2
Total Volume 2514.8 µm3
Max Euclidean Distance 322.622 µm
Max Path Distance 377.478 µm
Max Branch Order 6.0
Average Contraction 0.97244
Total Fragmentation 931.0
Partition Asymmetry 0.419458
Average Rall's Ratio 0.725714
Average Bifurcation Angle Local 50.4568 °
Average Bifurcation Angle Remote 53.6341 °
Fractal Dimension 1.00576
Complexity Summary
Relative Complexity 664.40 HH
State Equations 1913
Optimal Time-Step 0.00526 ms
Model Size
Sections 44
Compartments 158
State Equations 1913
Variable Time-Step Complexity
CVODE Steady State Step Frequency 30569 Hz
CVODE Steps Per AP 107
CVODE Benchmark Run Time 664.40 HH
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