Layer 2/3 Delayed Non-accommodating Small Basket Cell (4)

Model Type:
Cell
Neurolex IDs: Neocortex basket cell
Neocortex Layer 2
Neocortex Layer 3
Keywords: delayed non-accommodating,Layer 2, Layer 3, Layer 2/3,Fast-spiking, interneuron, GABAergic, inhibitory, neocortex, rat, somatosensory cortex, small, basket
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL001020
dNAC222_L23_SBC_cf92e1b802_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000106
KdShu2007.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL001020
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Fast Spikers (FS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -70.82 mV
Rheobase Current Interval (0.02701, 0.02747] nA
Threshold Current Interval (0.05859, 0.11719] nA
Bias Current (to -80.00 mV) -0.0133 nA
Testing Temperature 34.0 °C
Stability Interval [-0.625, 15.0] nA
AP 1-2 Amplitude Drop 1.4439 mV
AP 1 Steady State Amplitude Change 2.4295 mV
AP 1 Amplitude 85.0257 mV
AP 1 Width at Half Height 0.5000 ms
AP 1 Width (Peak To Trough) 3.1600 ms
AP 1 Rate of Change Peak to Trough -35.2331 mV/ms
AP 1 AHP Depth 26.3108 mV
AP2 Amplitude 83.5818 mV
AP2 Width at Half Height 0.5000 ms
AP 2 Width (Peak to Trough) 3.1600 ms
AP 2 Rate of Change Peak to Trough -34.8121 mV/ms
AP 2 AHP Depth 26.4246 mV
AP 1-2 Amplitude Change Percent -1.6982 %
AP 1-2 Half Width Change Percent 0.0000 %
AP 1-2 Rate of Change Peak to Trough Percent Change -1.1947 %
AP 1-2 AHP Depth Percent Change 0.4325 %
Input Resistance 709.7024 MΩ
AP 1 Delay Mean 11.3100 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 46.3700 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 35.4200 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -18.1818 %
Steady State Accommodation Mean -18.1818 %
Accommodation Rate to Steady State -0.0190 %/ms
Accommodation at Steady State Mean -27.8102 %
Accommodation Rate Mean at Steady State 820.8612 ms
ISI CV 11.9481
ISI Median 43.7000 ms
ISI Burst Mean Change 2.0536 %
Spike Rate (Strong Stimulation) 43.0000 Hz
AP 1 Delay Mean (Strong Stimulation) 4.1500 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 23.0100 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 19.5050 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2104.9700 ms
Frequency Filter Type Low-Pass
Frequency Filter Pass Below 77.8927 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 4411.88 µm2
Number of Stems 5.0
Number of Bifurcations 9.0
Number of Branches 22.0
Overall Width 151.226 µm
Overall Height 159.525 µm
Overall Depth 116.32 µm
Average Diameter 0.927048 µm
Total Length 1070.07 µm
Total Surface 2309.26 µm2
Total Volume 1393.75 µm3
Max Euclidean Distance 138.475 µm
Max Path Distance 171.507 µm
Max Branch Order 3.0
Average Contraction 0.953694
Total Fragmentation 365.0
Partition Asymmetry 0.555556
Average Rall's Ratio 1.45167
Average Bifurcation Angle Local 78.9436 °
Average Bifurcation Angle Remote 71.4667 °
Fractal Dimension 1.0113
Complexity Summary
State Equations 653
Optimal Time-Step 0.00775 ms
Relative Complexity 138.71 HH
Model Size
Sections 23
Compartments 53
State Equations 653
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00775 ms
Optimal Time-Step Error 0.25 %
Optimal Time-Step Benchmark Run Time 138.71 HH
 
Maximum Stable Time-Step 0.0625 ms
Maximum Stable Time-Step Error 1.37 %
Max. Stable Time-Step Benchmark Run Time 268.56 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 14448 Hz
CVODE Steps Per AP 406
CVODE Benchmark Run Time 130.75 HH
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