Layer 2/3 Delayed Non-accommodating Small Basket Cell (1)

Model Type:
Cell
Neurolex IDs: Neocortex basket cell
Neocortex Layer 2
Neocortex Layer 3
Keywords: delayed non-accommodating,Layer 2, Layer 3, Layer 2/3,Fast-spiking, interneuron, GABAergic, inhibitory, neocortex, rat, somatosensory cortex, small, basket
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL001017
dNAC222_L23_SBC_0c85d8e325_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000106
KdShu2007.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL001017
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Fast Spikers (FS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -71.64 mV
Rheobase Current Interval (0.03342, 0.03387] nA
Threshold Current Interval (0.05859, 0.11719] nA
Bias Current (to -80.00 mV) -0.0137 nA
Testing Temperature 34.0 °C
Stability Interval [-0.9375, 15.0] nA
AP 1-2 Amplitude Drop 0.6050 mV
AP 1 Steady State Amplitude Change 0.4412 mV
AP 1 Amplitude 76.9312 mV
AP 1 Width at Half Height 0.5800 ms
AP 1 Width (Peak To Trough) 2.9000 ms
AP 1 Rate of Change Peak to Trough -32.7861 mV/ms
AP 1 AHP Depth 18.1486 mV
AP2 Amplitude 76.3261 mV
AP2 Width at Half Height 0.5900 ms
AP 2 Width (Peak to Trough) 2.9700 ms
AP 2 Rate of Change Peak to Trough -31.8176 mV/ms
AP 2 AHP Depth 18.1721 mV
AP 1-2 Amplitude Change Percent -0.7865 %
AP 1-2 Half Width Change Percent 1.7241 %
AP 1-2 Rate of Change Peak to Trough Percent Change -2.9541 %
AP 1-2 AHP Depth Percent Change 0.1299 %
Input Resistance 610.8777 MΩ
AP 1 Delay Mean 14.5300 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 47.1700 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 33.2050 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean 0.0000 %
Steady State Accommodation Mean 8.3333 %
Accommodation Rate to Steady State 0.1767 %/ms
Accommodation at Steady State Mean -1.2816 %
Accommodation Rate Mean at Steady State 0.0025 ms
ISI CV 167.4557
ISI Median 32.9900 ms
ISI Burst Mean Change 3.4620 %
Spike Rate (Strong Stimulation) 59.0000 Hz
AP 1 Delay Mean (Strong Stimulation) 4.1700 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 18.8600 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 15.8750 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2094.6600 ms
Frequency Filter Type Low-Pass
Frequency Filter Pass Below 78.4872 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 2160.39 µm2
Number of Stems 6.0
Number of Bifurcations 14.0
Number of Branches 33.0
Overall Width 333.478 µm
Overall Height 470.675 µm
Overall Depth 139.45 µm
Average Diameter 0.647105 µm
Total Length 2440.35 µm
Total Surface 4264.94 µm2
Total Volume 1152.4 µm3
Max Euclidean Distance 318.538 µm
Max Path Distance 412.181 µm
Max Branch Order 8.0
Average Contraction 0.962993
Total Fragmentation 976.0
Partition Asymmetry 0.595238
Average Rall's Ratio 1.38875
Average Bifurcation Angle Local 51.9926 °
Average Bifurcation Angle Remote 74.9345 °
Fractal Dimension 1.0058
Complexity Summary
State Equations 1505
Optimal Time-Step 0.00768 ms
Relative Complexity 326.44 HH
Model Size
Sections 34
Compartments 124
State Equations 1505
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00768 ms
Optimal Time-Step Error 0.41 %
Optimal Time-Step Benchmark Run Time 326.44 HH
 
Maximum Stable Time-Step 0.0625 ms
Maximum Stable Time-Step Error 2.70 %
Max. Stable Time-Step Benchmark Run Time 626.68 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 16198 Hz
CVODE Steps Per AP 316
CVODE Benchmark Run Time 319.13 HH
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