Layer 2/3 Delayed Non-accommodating Nest Basket Cell (5)

Model Type:
Cell
Neurolex IDs: Neocortex basket cell
Neocortex Layer 2
Neocortex Layer 3
Keywords: delayed non-accommodating,Layer 2, Layer 3, Layer 2/3,Fast-spiking, interneuron, GABAergic, inhibitory, neocortex, rat, somatosensory cortex, nest, basket
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL001016
dNAC222_L23_NBC_ed12f3afab_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000106
KdShu2007.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL001016
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Fast Spikers (FS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -71.72 mV
Rheobase Current Interval (0.06638, 0.06752] nA
Threshold Current Interval (0.23438, 0.29297] nA
Bias Current (to -80.00 mV) -0.0212 nA
Testing Temperature 34.0 °C
Stability Interval [-1.875, 15.0] nA
AP 1-2 Amplitude Drop 1.8799 mV
AP 1 Steady State Amplitude Change 1.7875 mV
AP 1 Amplitude 68.1520 mV
AP 1 Width at Half Height 0.7000 ms
AP 1 Width (Peak To Trough) 4.1100 ms
AP 1 Rate of Change Peak to Trough -21.0867 mV/ms
AP 1 AHP Depth 18.5142 mV
AP2 Amplitude 66.2721 mV
AP2 Width at Half Height 0.7100 ms
AP 2 Width (Peak to Trough) 4.2300 ms
AP 2 Rate of Change Peak to Trough -20.0618 mV/ms
AP 2 AHP Depth 18.5892 mV
AP 1-2 Amplitude Change Percent -2.7583 %
AP 1-2 Half Width Change Percent 1.4286 %
AP 1-2 Rate of Change Peak to Trough Percent Change -4.8603 %
AP 1-2 AHP Depth Percent Change 0.4052 %
Input Resistance 389.0747 MΩ
AP 1 Delay Mean 12.5800 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 44.3300 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 32.2350 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean 0.0000 %
Steady State Accommodation Mean 0.0000 %
Accommodation Rate to Steady State 0.0000 %/ms
Accommodation at Steady State Mean -6.9702 %
Accommodation Rate Mean at Steady State 2967.8940 ms
ISI CV 90.7828
ISI Median 33.0000 ms
ISI Burst Mean Change 3.0551 %
Spike Rate (Strong Stimulation) 56.5000 Hz
AP 1 Delay Mean (Strong Stimulation) 4.5700 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 20.0400 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 16.4750 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2092.2500 ms
Frequency Filter Type Low-Pass
Frequency Filter Pass Below 113.8554 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 8107.62 µm2
Number of Stems 8.0
Number of Bifurcations 24.0
Number of Branches 55.0
Overall Width 237.926 µm
Overall Height 265.975 µm
Overall Depth 157.56 µm
Average Diameter 0.946172 µm
Total Length 2713.88 µm
Total Surface 6199.76 µm2
Total Volume 3421.25 µm3
Max Euclidean Distance 270.603 µm
Max Path Distance 289.304 µm
Max Branch Order 6.0
Average Contraction 0.978691
Total Fragmentation 796.0
Partition Asymmetry 0.441667
Average Rall's Ratio 1.35625
Average Bifurcation Angle Local 64.8079 °
Average Bifurcation Angle Remote 64.6719 °
Fractal Dimension 1.00328
Complexity Summary
State Equations 1601
Optimal Time-Step 0.00777 ms
Relative Complexity 331.67 HH
Model Size
Sections 56
Compartments 132
State Equations 1601
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00777 ms
Optimal Time-Step Error 0.35 %
Optimal Time-Step Benchmark Run Time 331.67 HH
 
Maximum Stable Time-Step 0.0625 ms
Maximum Stable Time-Step Error 2.46 %
Max. Stable Time-Step Benchmark Run Time 644.44 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 14575 Hz
CVODE Steps Per AP 309
CVODE Benchmark Run Time 299.55 HH
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