Layer 2/3 Delayed Non-accommodating Nest Basket Cell (3)

Model Type:
Cell
Neurolex IDs: Neocortex basket cell
Neocortex Layer 2
Neocortex Layer 3
Keywords: delayed non-accommodating,Layer 2, Layer 3, Layer 2/3,Fast-spiking, interneuron, GABAergic, inhibitory, neocortex, rat, somatosensory cortex, nest, basket
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL001014
dNAC222_L23_NBC_df01e73cd3_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000106
KdShu2007.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL001014
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Fast Spikers (FS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -71.73 mV
Rheobase Current Interval (0.06134, 0.06226] nA
Threshold Current Interval (0.17578, 0.23438] nA
Bias Current (to -80.00 mV) -0.0226 nA
Testing Temperature 34.0 °C
Stability Interval [-1.5625, 15.0] nA
AP 1-2 Amplitude Drop 1.3968 mV
AP 1 Steady State Amplitude Change 0.7862 mV
AP 1 Amplitude 69.7050 mV
AP 1 Width at Half Height 0.6600 ms
AP 1 Width (Peak To Trough) 3.2100 ms
AP 1 Rate of Change Peak to Trough -26.1416 mV/ms
AP 1 AHP Depth 14.2094 mV
AP2 Amplitude 68.3082 mV
AP2 Width at Half Height 0.6600 ms
AP 2 Width (Peak to Trough) 3.4000 ms
AP 2 Rate of Change Peak to Trough -24.3246 mV/ms
AP 2 AHP Depth 14.3954 mV
AP 1-2 Amplitude Change Percent -2.0039 %
AP 1-2 Half Width Change Percent -0.0000 %
AP 1-2 Rate of Change Peak to Trough Percent Change -6.9505 %
AP 1-2 AHP Depth Percent Change 1.3093 %
Input Resistance 355.0300 MΩ
AP 1 Delay Mean 14.3000 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 45.5500 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 31.8600 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean 0.0000 %
Steady State Accommodation Mean 7.6923 %
Accommodation Rate to Steady State 0.1689 %/ms
Accommodation at Steady State Mean -0.0000 %
Accommodation Rate Mean at Steady State 154.8950 ms
ISI CV 43.1696
ISI Median 30.2400 ms
ISI Burst Mean Change 3.9040 %
Spike Rate (Strong Stimulation) 63.5000 Hz
AP 1 Delay Mean (Strong Stimulation) 4.5500 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 18.5300 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 15.2800 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2084.5500 ms
Frequency Filter Type Low-Pass
Frequency Filter Pass Below 110.2492 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 4049.41 µm2
Number of Stems 6.0
Number of Bifurcations 18.0
Number of Branches 41.0
Overall Width 350.686 µm
Overall Height 463.869 µm
Overall Depth 267.63 µm
Average Diameter 0.641248 µm
Total Length 3813.11 µm
Total Surface 7330.63 µm2
Total Volume 2268.13 µm3
Max Euclidean Distance 347.589 µm
Max Path Distance 413.883 µm
Max Branch Order 6.0
Average Contraction 0.94881
Total Fragmentation 1416.0
Partition Asymmetry 0.48642
Average Rall's Ratio 1.27636
Average Bifurcation Angle Local 34.7392 °
Average Bifurcation Angle Remote 50.691 °
Fractal Dimension 1.0072
Complexity Summary
State Equations 2297
Optimal Time-Step 0.00773 ms
Relative Complexity 496.24 HH
Model Size
Sections 42
Compartments 190
State Equations 2297
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00773 ms
Optimal Time-Step Error 0.24 %
Optimal Time-Step Benchmark Run Time 496.24 HH
 
Maximum Stable Time-Step 0.0625 ms
Maximum Stable Time-Step Error 1.83 %
Max. Stable Time-Step Benchmark Run Time 959.03 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 14752 Hz
CVODE Steps Per AP 416
CVODE Benchmark Run Time 477.06 HH
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