Layer 2/3 Delayed Non-accommodating Nest Basket Cell (2)

Model Type:
Cell
Neurolex IDs: Neocortex basket cell
Neocortex Layer 2
Neocortex Layer 3
Keywords: delayed non-accommodating,Layer 2, Layer 3, Layer 2/3,Fast-spiking, interneuron, GABAergic, inhibitory, neocortex, rat, somatosensory cortex, nest, basket
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL001013
dNAC222_L23_NBC_46256e0cca_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000106
KdShu2007.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL001013
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Fast Spikers (FS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -71.71 mV
Rheobase Current Interval (0.07553, 0.07668] nA
Threshold Current Interval (0.23438, 0.29297] nA
Bias Current (to -80.00 mV) -0.0273 nA
Testing Temperature 34.0 °C
Stability Interval [-1.5625, 15.0] nA
AP 1-2 Amplitude Drop 1.8023 mV
AP 1 Steady State Amplitude Change 1.1689 mV
AP 1 Amplitude 70.2964 mV
AP 1 Width at Half Height 0.6500 ms
AP 1 Width (Peak To Trough) 3.0400 ms
AP 1 Rate of Change Peak to Trough -27.3397 mV/ms
AP 1 AHP Depth 12.8164 mV
AP2 Amplitude 68.4941 mV
AP2 Width at Half Height 0.6600 ms
AP 2 Width (Peak to Trough) 3.1800 ms
AP 2 Rate of Change Peak to Trough -25.7268 mV/ms
AP 2 AHP Depth 13.3172 mV
AP 1-2 Amplitude Change Percent -2.5639 %
AP 1-2 Half Width Change Percent 1.5385 %
AP 1-2 Rate of Change Peak to Trough Percent Change -5.8995 %
AP 1-2 AHP Depth Percent Change 3.9073 %
Input Resistance 289.7930 MΩ
AP 1 Delay Mean 13.0100 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 41.1100 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 28.9050 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean 7.1429 %
Steady State Accommodation Mean 7.1429 %
Accommodation Rate to Steady State 0.1737 %/ms
Accommodation at Steady State Mean -0.0000 %
Accommodation Rate Mean at Steady State 174.0839 ms
ISI CV 27.6529
ISI Median 26.7300 ms
ISI Burst Mean Change 5.7295 %
Spike Rate (Strong Stimulation) 72.5000 Hz
AP 1 Delay Mean (Strong Stimulation) 3.7500 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 15.8900 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 13.4400 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2080.8300 ms
Frequency Filter Type Low-Pass
Frequency Filter Pass Below 46.3206 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 4653.43 µm2
Number of Stems 7.0
Number of Bifurcations 23.0
Number of Branches 52.0
Overall Width 474.615 µm
Overall Height 553.319 µm
Overall Depth 482.89 µm
Average Diameter 0.599818 µm
Total Length 5583.85 µm
Total Surface 9615.91 µm2
Total Volume 2561.36 µm3
Max Euclidean Distance 441.934 µm
Max Path Distance 600.528 µm
Max Branch Order 5.0
Average Contraction 0.960659
Total Fragmentation 1583.0
Partition Asymmetry 0.313527
Average Rall's Ratio 1.24536
Average Bifurcation Angle Local 54.3713 °
Average Bifurcation Angle Remote 70.6248 °
Fractal Dimension 1.00695
Complexity Summary
State Equations 3317
Optimal Time-Step 0.00767 ms
Relative Complexity 717.71 HH
Model Size
Sections 53
Compartments 275
State Equations 3317
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00767 ms
Optimal Time-Step Error 0.32 %
Optimal Time-Step Benchmark Run Time 717.71 HH
 
Maximum Stable Time-Step 0.0625 ms
Maximum Stable Time-Step Error 2.05 %
Max. Stable Time-Step Benchmark Run Time 1376.33 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 16834 Hz
CVODE Steps Per AP 275
CVODE Benchmark Run Time 709.18 HH
Website & Images Copyright NeuroML © 2019 For questions: Contact us Links: Search Test |  ModelDB WS