Layer 2/3 Delayed Non-accommodating Nest Basket Cell (1)

Model Type:
Cell
Neurolex IDs: Neocortex basket cell
Neocortex Layer 2
Neocortex Layer 3
Keywords: delayed non-accommodating,Layer 2, Layer 3, Layer 2/3,Fast-spiking, interneuron, GABAergic, inhibitory, neocortex, rat, somatosensory cortex, nest, basket
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL001012
dNAC222_L23_NBC_2f216c0d74_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000106
KdShu2007.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL001012
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Fast Spikers (FS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -71.79 mV
Rheobase Current Interval (0.12016, 0.12177] nA
Threshold Current Interval (0.35156, 0.41016] nA
Bias Current (to -80.00 mV) -0.0360 nA
Testing Temperature 34.0 °C
Stability Interval [-2.5, 15.0] nA
AP 1-2 Amplitude Drop 1.8756 mV
AP 1 Steady State Amplitude Change 1.4239 mV
AP 1 Amplitude 68.4013 mV
AP 1 Width at Half Height 0.6700 ms
AP 1 Width (Peak To Trough) 3.3000 ms
AP 1 Rate of Change Peak to Trough -25.7502 mV/ms
AP 1 AHP Depth 16.5743 mV
AP2 Amplitude 66.5257 mV
AP2 Width at Half Height 0.6800 ms
AP 2 Width (Peak to Trough) 3.4200 ms
AP 2 Rate of Change Peak to Trough -24.3670 mV/ms
AP 2 AHP Depth 16.8095 mV
AP 1-2 Amplitude Change Percent -2.7420 %
AP 1-2 Half Width Change Percent 1.4925 %
AP 1-2 Rate of Change Peak to Trough Percent Change -5.3715 %
AP 1-2 AHP Depth Percent Change 1.4190 %
Input Resistance 214.9657 MΩ
AP 1 Delay Mean 11.6600 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 40.0200 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 29.0650 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean 0.0000 %
Steady State Accommodation Mean 7.1429 %
Accommodation Rate to Steady State 0.1785 %/ms
Accommodation at Steady State Mean -0.0000 %
Accommodation Rate Mean at Steady State 118.5422 ms
ISI CV 46.9629
ISI Median 27.7600 ms
ISI Burst Mean Change 4.9718 %
Spike Rate (Strong Stimulation) 67.5000 Hz
AP 1 Delay Mean (Strong Stimulation) 3.7800 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 16.7200 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 14.1600 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2074.1300 ms
Frequency Filter Type Low-Pass
Frequency Filter Pass Below 133.8908 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 11905.9 µm2
Number of Stems 10.0
Number of Bifurcations 31.0
Number of Branches 71.0
Overall Width 292.141 µm
Overall Height 510.47 µm
Overall Depth 233.88 µm
Average Diameter 0.857665 µm
Total Length 4640.62 µm
Total Surface 11987.3 µm2
Total Volume 6015.93 µm3
Max Euclidean Distance 364.704 µm
Max Path Distance 442.084 µm
Max Branch Order 5.0
Average Contraction 0.967612
Total Fragmentation 1419.0
Partition Asymmetry 0.309268
Average Rall's Ratio 0.999118
Average Bifurcation Angle Local 41.3205 °
Average Bifurcation Angle Remote 42.255 °
Fractal Dimension 1.00533
Complexity Summary
State Equations 2789
Optimal Time-Step 0.00776 ms
Relative Complexity 624.77 HH
Model Size
Sections 73
Compartments 231
State Equations 2789
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00776 ms
Optimal Time-Step Error 0.41 %
Optimal Time-Step Benchmark Run Time 624.77 HH
 
Maximum Stable Time-Step 0.0625 ms
Maximum Stable Time-Step Error 2.37 %
Max. Stable Time-Step Benchmark Run Time 1211.54 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 15002 Hz
CVODE Steps Per AP 318
CVODE Benchmark Run Time 579.64 HH
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