Layer 2/3 Delayed Non-accommodating Martinotti Cell (5)

Model Type:
Cell
Neurolex IDs: Neocortex Layer 2
Neocortex Layer 3
Martinotti Cell
Keywords: delayed non-accommodating,Layer 2, Layer 3, Layer 2/3,GABAergic, inhibitory, neocortex, rat, somatosensory cortex, Martinotti
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL001011
dNAC222_L23_MC_b7a2c9d0ae_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000106
KdShu2007.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL001011
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Fast Spikers (FS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -72.02 mV
Rheobase Current Interval (0.07690, 0.07828] nA
Threshold Current Interval (0.29297, 0.35156] nA
Bias Current (to -80.00 mV) -0.0238 nA
Testing Temperature 34.0 °C
Stability Interval [-2.1875, 15.0] nA
AP 1-2 Amplitude Drop 1.1416 mV
AP 1 Steady State Amplitude Change 0.6761 mV
AP 1 Amplitude 71.2860 mV
AP 1 Width at Half Height 0.6600 ms
AP 1 Width (Peak To Trough) 4.0100 ms
AP 1 Rate of Change Peak to Trough -21.1643 mV/ms
AP 1 AHP Depth 13.5831 mV
AP2 Amplitude 70.1444 mV
AP2 Width at Half Height 0.6600 ms
AP 2 Width (Peak to Trough) 4.2900 ms
AP 2 Rate of Change Peak to Trough -19.5960 mV/ms
AP 2 AHP Depth 13.9225 mV
AP 1-2 Amplitude Change Percent -1.6014 %
AP 1-2 Half Width Change Percent 0.0000 %
AP 1-2 Rate of Change Peak to Trough Percent Change -7.4103 %
AP 1-2 AHP Depth Percent Change 2.4986 %
Input Resistance 318.9950 MΩ
AP 1 Delay Mean 14.5100 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 45.3000 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 31.3600 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean 7.6923 %
Steady State Accommodation Mean 7.6923 %
Accommodation Rate to Steady State 0.1698 %/ms
Accommodation at Steady State Mean -0.0000 %
Accommodation Rate Mean at Steady State 106.0497 ms
ISI CV 29.3235
ISI Median 28.9200 ms
ISI Burst Mean Change 3.7025 %
Spike Rate (Strong Stimulation) 66.0000 Hz
AP 1 Delay Mean (Strong Stimulation) 4.7800 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 18.3800 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 14.8250 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2089.7100 ms
Frequency Filter Type Constant
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 4763.86 µm2
Number of Stems 5.0
Number of Bifurcations 36.0
Number of Branches 76.0
Overall Width 298.659 µm
Overall Height 294.862 µm
Overall Depth 174.9 µm
Average Diameter 0.794947 µm
Total Length 4095.17 µm
Total Surface 8012.35 µm2
Total Volume 2612.01 µm3
Max Euclidean Distance 255.653 µm
Max Path Distance 383.17 µm
Max Branch Order 8.0
Average Contraction 0.970065
Total Fragmentation 987.0
Partition Asymmetry 0.589087
Average Rall's Ratio 1.36292
Average Bifurcation Angle Local 48.6487 °
Average Bifurcation Angle Remote 60.785 °
Fractal Dimension 1.00467
Complexity Summary
State Equations 2501
Optimal Time-Step 0.00768 ms
Relative Complexity 536.55 HH
Model Size
Sections 77
Compartments 207
State Equations 2501
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00768 ms
Optimal Time-Step Error 0.30 %
Optimal Time-Step Benchmark Run Time 536.55 HH
 
Maximum Stable Time-Step 0.0625 ms
Maximum Stable Time-Step Error 1.53 %
Max. Stable Time-Step Benchmark Run Time 1029.97 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 15101 Hz
CVODE Steps Per AP 308
CVODE Benchmark Run Time 492.70 HH
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