Layer 2/3 Delayed Non-accommodating Martinotti Cell (4)

Model Type:
Cell
Neurolex IDs: Neocortex Layer 2
Neocortex Layer 3
Martinotti Cell
Keywords: delayed non-accommodating,Layer 2, Layer 3, Layer 2/3,GABAergic, inhibitory, neocortex, rat, somatosensory cortex, Martinotti
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL001010
dNAC222_L23_MC_940ffcbb27_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000106
KdShu2007.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL001010
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Fast Spikers (FS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -71.75 mV
Rheobase Current Interval (0.05722, 0.05836] nA
Threshold Current Interval (0.23438, 0.29297] nA
Bias Current (to -80.00 mV) -0.0189 nA
Testing Temperature 34.0 °C
Stability Interval [-0.9375, 15.0] nA
AP 1-2 Amplitude Drop 0.6498 mV
AP 1 Steady State Amplitude Change 0.5129 mV
AP 1 Amplitude 70.5534 mV
AP 1 Width at Half Height 0.6500 ms
AP 1 Width (Peak To Trough) 3.9400 ms
AP 1 Rate of Change Peak to Trough -22.8608 mV/ms
AP 1 AHP Depth 19.5182 mV
AP2 Amplitude 69.9036 mV
AP2 Width at Half Height 0.6600 ms
AP 2 Width (Peak to Trough) 4.0400 ms
AP 2 Rate of Change Peak to Trough -22.0922 mV/ms
AP 2 AHP Depth 19.3488 mV
AP 1-2 Amplitude Change Percent -0.9211 %
AP 1-2 Half Width Change Percent 1.5385 %
AP 1-2 Rate of Change Peak to Trough Percent Change -3.3623 %
AP 1-2 AHP Depth Percent Change -0.8678 %
Input Resistance 432.5619 MΩ
AP 1 Delay Mean 14.3300 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 46.4800 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 32.6050 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean 0.0000 %
Steady State Accommodation Mean 0.0000 %
Accommodation Rate to Steady State 0.0000 %/ms
Accommodation at Steady State Mean -1.3111 %
Accommodation Rate Mean at Steady State 1.0787 ms
ISI CV 244.4661
ISI Median 32.5750 ms
ISI Burst Mean Change 2.8305 %
Spike Rate (Strong Stimulation) 57.0000 Hz
AP 1 Delay Mean (Strong Stimulation) 4.9700 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 20.6500 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 16.6150 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2109.8700 ms
Frequency Filter Type Constant
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 4738.53 µm2
Number of Stems 6.0
Number of Bifurcations 30.0
Number of Branches 65.0
Overall Width 230.634 µm
Overall Height 339.616 µm
Overall Depth 123.23 µm
Average Diameter 0.763567 µm
Total Length 2709.44 µm
Total Surface 6102.41 µm2
Total Volume 2232.31 µm3
Max Euclidean Distance 206.651 µm
Max Path Distance 263.869 µm
Max Branch Order 6.0
Average Contraction 0.978033
Total Fragmentation 1408.0
Partition Asymmetry 0.500926
Average Rall's Ratio 1.838
Average Bifurcation Angle Local 48.6315 °
Average Bifurcation Angle Remote 59.4743 °
Fractal Dimension 1.00404
Complexity Summary
State Equations 1757
Optimal Time-Step 0.00768 ms
Relative Complexity 373.76 HH
Model Size
Sections 65
Compartments 145
State Equations 1757
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00768 ms
Optimal Time-Step Error 0.18 %
Optimal Time-Step Benchmark Run Time 373.76 HH
 
Maximum Stable Time-Step 0.0625 ms
Maximum Stable Time-Step Error 1.41 %
Max. Stable Time-Step Benchmark Run Time 717.20 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 14899 Hz
CVODE Steps Per AP 375
CVODE Benchmark Run Time 351.98 HH
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