Layer 2/3 Delayed Non-accommodating Large Basket Cell (5)

Model Type:
Cell
Neurolex IDs: Neocortex basket cell
Neocortex Layer 2
Neocortex Layer 3
Keywords: delayed non-accommodating,Layer 2, Layer 3, Layer 2/3,Fast-spiking, interneuron, GABAergic, inhibitory, neocortex, rat, somatosensory cortex, large, basket
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL001006
dNAC222_L23_LBC_df15689e81_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000106
KdShu2007.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL001006
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Fast Spikers (FS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -71.62 mV
Rheobase Current Interval (0.08240, 0.08354] nA
Threshold Current Interval (0.23438, 0.29297] nA
Bias Current (to -80.00 mV) -0.0261 nA
Testing Temperature 34.0 °C
Stability Interval [-1.875, 15.0] nA
AP 1-2 Amplitude Drop 1.2490 mV
AP 1 Steady State Amplitude Change 1.1642 mV
AP 1 Amplitude 73.6362 mV
AP 1 Width at Half Height 0.6100 ms
AP 1 Width (Peak To Trough) 3.0500 ms
AP 1 Rate of Change Peak to Trough -30.4441 mV/ms
AP 1 AHP Depth 19.2183 mV
AP2 Amplitude 72.3872 mV
AP2 Width at Half Height 0.6200 ms
AP 2 Width (Peak to Trough) 3.0900 ms
AP 2 Rate of Change Peak to Trough -29.5828 mV/ms
AP 2 AHP Depth 19.0236 mV
AP 1-2 Amplitude Change Percent -1.6962 %
AP 1-2 Half Width Change Percent 1.6393 %
AP 1-2 Rate of Change Peak to Trough Percent Change -2.8292 %
AP 1-2 AHP Depth Percent Change -1.0130 %
Input Resistance 312.4811 MΩ
AP 1 Delay Mean 11.1800 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 40.6600 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 30.0800 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean 0.0000 %
Steady State Accommodation Mean 0.0000 %
Accommodation Rate to Steady State 0.0000 %/ms
Accommodation at Steady State Mean -3.2967 %
Accommodation Rate Mean at Steady State 1.4462 ms
ISI CV 147.7085
ISI Median 30.5100 ms
ISI Burst Mean Change 4.0706 %
Spike Rate (Strong Stimulation) 61.0000 Hz
AP 1 Delay Mean (Strong Stimulation) 3.7700 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 17.8900 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 15.2600 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2077.7600 ms
Frequency Filter Type Low-Pass
Frequency Filter Pass Below 118.7406 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 8236.63 µm2
Number of Stems 6.0
Number of Bifurcations 20.0
Number of Branches 45.0
Overall Width 273.97 µm
Overall Height 431.487 µm
Overall Depth 125.23 µm
Average Diameter 0.792523 µm
Total Length 3322.38 µm
Total Surface 7568.56 µm2
Total Volume 3861.34 µm3
Max Euclidean Distance 437.431 µm
Max Path Distance 473.859 µm
Max Branch Order 5.0
Average Contraction 0.95342
Total Fragmentation 1287.0
Partition Asymmetry 0.385
Average Rall's Ratio 1.11147
Average Bifurcation Angle Local 48.8675 °
Average Bifurcation Angle Remote 62.8498 °
Fractal Dimension 1.00669
Complexity Summary
State Equations 1985
Optimal Time-Step 0.00769 ms
Relative Complexity 421.81 HH
Model Size
Sections 46
Compartments 164
State Equations 1985
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00769 ms
Optimal Time-Step Error 0.35 %
Optimal Time-Step Benchmark Run Time 421.81 HH
 
Maximum Stable Time-Step 0.0625 ms
Maximum Stable Time-Step Error 1.98 %
Max. Stable Time-Step Benchmark Run Time 811.11 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 15316 Hz
CVODE Steps Per AP 331
CVODE Benchmark Run Time 397.52 HH
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