Layer 2/3 Delayed Non-accommodating Large Basket Cell (3)

Model Type:
Cell
Neurolex IDs: Neocortex basket cell
Neocortex Layer 2
Neocortex Layer 3
Keywords: delayed non-accommodating,Layer 2, Layer 3, Layer 2/3,Fast-spiking, interneuron, GABAergic, inhibitory, neocortex, rat, somatosensory cortex, large, basket
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL001004
dNAC222_L23_LBC_3872d55b42_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000106
KdShu2007.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL001004
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Fast Spikers (FS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -71.76 mV
Rheobase Current Interval (0.04852, 0.04944] nA
Threshold Current Interval (0.17578, 0.23438] nA
Bias Current (to -80.00 mV) -0.0159 nA
Testing Temperature 34.0 °C
Stability Interval [-1.25, 15.0] nA
AP 1-2 Amplitude Drop 1.0091 mV
AP 1 Steady State Amplitude Change 0.9568 mV
AP 1 Amplitude 72.0304 mV
AP 1 Width at Half Height 0.6800 ms
AP 1 Width (Peak To Trough) 4.0400 ms
AP 1 Rate of Change Peak to Trough -22.5383 mV/ms
AP 1 AHP Depth 19.0243 mV
AP2 Amplitude 71.0212 mV
AP2 Width at Half Height 0.6800 ms
AP 2 Width (Peak to Trough) 4.1200 ms
AP 2 Rate of Change Peak to Trough -21.8815 mV/ms
AP 2 AHP Depth 19.1305 mV
AP 1-2 Amplitude Change Percent -1.4010 %
AP 1-2 Half Width Change Percent 0.0000 %
AP 1-2 Rate of Change Peak to Trough Percent Change -2.9141 %
AP 1-2 AHP Depth Percent Change 0.5583 %
Input Resistance 508.9263 MΩ
AP 1 Delay Mean 13.9500 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 46.8300 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 33.3150 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean 0.0000 %
Steady State Accommodation Mean -8.3333 %
Accommodation Rate to Steady State -0.1779 %/ms
Accommodation at Steady State Mean -2.6474 %
Accommodation Rate Mean at Steady State 9.9849 ms
ISI CV 131.0683
ISI Median 33.7900 ms
ISI Burst Mean Change 2.6460 %
Spike Rate (Strong Stimulation) 56.0000 Hz
AP 1 Delay Mean (Strong Stimulation) 4.8600 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 20.6300 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 16.7300 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2092.2000 ms
Frequency Filter Type Low-Pass
Frequency Filter Pass Below 98.0028 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 3346.75 µm2
Number of Stems 7.0
Number of Bifurcations 22.0
Number of Branches 50.0
Overall Width 135.257 µm
Overall Height 475.687 µm
Overall Depth 122.52 µm
Average Diameter 0.719584 µm
Total Length 2619.39 µm
Total Surface 5176.53 µm2
Total Volume 1708.12 µm3
Max Euclidean Distance 378.886 µm
Max Path Distance 386.905 µm
Max Branch Order 9.0
Average Contraction 0.982348
Total Fragmentation 792.0
Partition Asymmetry 0.590043
Average Rall's Ratio 1.28333
Average Bifurcation Angle Local 32.547 °
Average Bifurcation Angle Remote 42.5434 °
Fractal Dimension 1.00292
Complexity Summary
State Equations 1637
Optimal Time-Step 0.00858 ms
Relative Complexity 318.26 HH
Model Size
Sections 51
Compartments 135
State Equations 1637
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00858 ms
Optimal Time-Step Error 1.52 %
Optimal Time-Step Benchmark Run Time 318.26 HH
 
Maximum Stable Time-Step 0.0625 ms
Maximum Stable Time-Step Error 2.53 %
Max. Stable Time-Step Benchmark Run Time 682.21 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 15165 Hz
CVODE Steps Per AP 330
CVODE Benchmark Run Time 331.38 HH
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