Layer 2/3 Delayed Non-accommodating Large Basket Cell (1)

Model Type:
Cell
Neurolex IDs: Neocortex basket cell
Neocortex Layer 2
Neocortex Layer 3
Keywords: delayed non-accommodating,Layer 2, Layer 3, Layer 2/3,Fast-spiking, interneuron, GABAergic, inhibitory, neocortex, rat, somatosensory cortex, large, basket, biophysical, delayed non-accommodating large basket cell, Realistic Network, Neuron or other electrically excitable cell, Synapse, Spatio-temporal Activity Patterns, Detailed Neuronal Models
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL001002
dNAC222_L23_LBC_19cea46eb3_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000106
KdShu2007.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL001002
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Fast Spikers (FS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -71.44 mV
Rheobase Current Interval (0.03571, 0.03616] nA
Threshold Current Interval (0.05859, 0.11719] nA
Bias Current (to -80.00 mV) -0.0136 nA
Testing Temperature 34.0 °C
Stability Interval [-0.625, 15.0] nA
AP 1-2 Amplitude Drop 0.4764 mV
AP 1 Steady State Amplitude Change 0.6608 mV
AP 1 Amplitude 83.8016 mV
AP 1 Width at Half Height 0.5000 ms
AP 1 Width (Peak To Trough) 2.2300 ms
AP 1 Rate of Change Peak to Trough -47.8303 mV/ms
AP 1 AHP Depth 22.8599 mV
AP2 Amplitude 83.3252 mV
AP2 Width at Half Height 0.4900 ms
AP 2 Width (Peak to Trough) 2.2300 ms
AP 2 Rate of Change Peak to Trough -47.4625 mV/ms
AP 2 AHP Depth 22.5163 mV
AP 1-2 Amplitude Change Percent -0.5685 %
AP 1-2 Half Width Change Percent -2.0000 %
AP 1-2 Rate of Change Peak to Trough Percent Change -0.7688 %
AP 1-2 AHP Depth Percent Change -1.5030 %
Input Resistance 643.7365 MΩ
AP 1 Delay Mean 9.4500 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 39.3100 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 30.4150 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -7.6923 %
Steady State Accommodation Mean -7.6923 %
Accommodation Rate to Steady State -0.0100 %/ms
Accommodation at Steady State Mean -15.4613 %
Accommodation Rate Mean at Steady State 1239.8127 ms
ISI CV 25.6155
ISI Median 33.4150 ms
ISI Burst Mean Change 3.7173 %
Spike Rate (Strong Stimulation) 54.5000 Hz
AP 1 Delay Mean (Strong Stimulation) 2.9800 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 18.2900 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 16.3050 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2069.5600 ms
Frequency Filter Type Low-Pass
Frequency Filter Pass Below 111.3549 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 4341.59 µm2
Number of Stems 10.0
Number of Bifurcations 20.0
Number of Branches 49.0
Overall Width 319.219 µm
Overall Height 429.435 µm
Overall Depth 231.67 µm
Average Diameter 0.326367 µm
Total Length 4020.12 µm
Total Surface 3720.68 µm2
Total Volume 1414.17 µm3
Max Euclidean Distance 358.051 µm
Max Path Distance 393.867 µm
Max Branch Order 7.0
Average Contraction 0.951072
Total Fragmentation 2818.0
Partition Asymmetry 0.541667
Average Rall's Ratio 0.629615
Average Bifurcation Angle Local 17.6084 °
Average Bifurcation Angle Remote 50.734 °
Fractal Dimension 1.00936
Complexity Summary
Relative Complexity 534.31 HH
State Equations 2441
Optimal Time-Step 0.00541 ms
Model Size
Sections 50
Compartments 202
State Equations 2441
Variable Time-Step Complexity
CVODE Steady State Step Frequency 16846 Hz
CVODE Steps Per AP 371
CVODE Benchmark Run Time 534.31 HH
Website & Images Copyright NeuroML © 2024 For questions: Contact us Links: Search Test |  ModelDB WS