Layer 2/3 Delayed Non-accommodating Chandelier Cell (3)

Model Type:
Cell
Neurolex IDs: Neocortex Layer 2
Neocortex Layer 3
Chandelier Cell
Keywords: delayed non-accommodating,Layer 2, Layer 3, Layer 2/3,GABAergic, inhibitory, neocortex, rat, somatosensory cortex, chandelier, biophysical, delayed non-accommodating chandelier cell, Realistic Network, Neuron or other electrically excitable cell, Synapse, Spatio-temporal Activity Patterns, Detailed Neuronal Models
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000999
dNAC222_L23_ChC_97f4d271eb_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000106
KdShu2007.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000999
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Fast Spikers (FS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -71.84 mV
Rheobase Current Interval (0.06134, 0.06226] nA
Threshold Current Interval (0.17578, 0.23438] nA
Bias Current (to -80.00 mV) -0.0215 nA
Testing Temperature 34.0 °C
Stability Interval [-1.5625, 15.0] nA
AP 1-2 Amplitude Drop 0.9174 mV
AP 1 Steady State Amplitude Change 0.6040 mV
AP 1 Amplitude 75.1065 mV
AP 1 Width at Half Height 0.6000 ms
AP 1 Width (Peak To Trough) 2.4400 ms
AP 1 Rate of Change Peak to Trough -37.0415 mV/ms
AP 1 AHP Depth 15.2747 mV
AP2 Amplitude 74.1891 mV
AP2 Width at Half Height 0.6100 ms
AP 2 Width (Peak to Trough) 2.4000 ms
AP 2 Rate of Change Peak to Trough -37.3658 mV/ms
AP 2 AHP Depth 15.4888 mV
AP 1-2 Amplitude Change Percent -1.2214 %
AP 1-2 Half Width Change Percent 1.6667 %
AP 1-2 Rate of Change Peak to Trough Percent Change 0.8756 %
AP 1-2 AHP Depth Percent Change 1.4019 %
Input Resistance 362.4993 MΩ
AP 1 Delay Mean 14.7700 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 45.5100 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 31.3750 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean 7.6923 %
Steady State Accommodation Mean 7.6923 %
Accommodation Rate to Steady State 0.1690 %/ms
Accommodation at Steady State Mean -0.0000 %
Accommodation Rate Mean at Steady State 162.9195 ms
ISI CV 33.1248
ISI Median 29.3000 ms
ISI Burst Mean Change 4.1314 %
Spike Rate (Strong Stimulation) 66.0000 Hz
AP 1 Delay Mean (Strong Stimulation) 4.3700 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 17.6600 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 14.6200 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2081.5100 ms
Frequency Filter Type Low-Pass
Frequency Filter Pass Below 112.2488 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 3444.6 µm2
Number of Stems 4.0
Number of Bifurcations 31.0
Number of Branches 65.0
Overall Width 282.997 µm
Overall Height 472.615 µm
Overall Depth 191.82 µm
Average Diameter 0.658652 µm
Total Length 3981.0 µm
Total Surface 7493.9 µm2
Total Volume 2056.52 µm3
Max Euclidean Distance 321.445 µm
Max Path Distance 337.402 µm
Max Branch Order 8.0
Average Contraction 0.978818
Total Fragmentation 1133.0
Partition Asymmetry 0.4087
Average Rall's Ratio 1.08955
Average Bifurcation Angle Local 28.738 °
Average Bifurcation Angle Remote 43.0561 °
Fractal Dimension 1.00397
Complexity Summary
Relative Complexity 513.88 HH
State Equations 2489
Optimal Time-Step 0.00772 ms
Model Size
Sections 66
Compartments 206
State Equations 2489
Variable Time-Step Complexity
CVODE Steady State Step Frequency 15682 Hz
CVODE Steps Per AP 303
CVODE Benchmark Run Time 513.88 HH
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